Predictive Markers for Longitudinal TMJ Integrity

纵向颞下颌关节完整性的预测标记

• 批准号: 10648171
• 负责人: YOLY M GONZALEZ-STUCKER
• 金额: $ 17.99万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-05 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648171
• 关键词: Address; Affect; American; Anatomy; Animal Model; Area; Arithmetic; Behavior; Biological Markers; Cephalic; Characteristics; Clinical; Consensus; Data; Data Set; Degenerative Disorder; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease Progression; Engineering; Environment; Failure; Fatigue; Female; Frequencies; Goals; Head; Health; High Prevalence; Hip region structure; Human; Image; Individual; Jaw; Joints; Knee; Length; Mandibular Condyle; Measurement; Measures; Mechanics; Medicine; Morphology; Muscle; National Institute of Dental and Craniofacial Research; Nickel; Occlusal Planes; Outcome; Pain; Patients; Pilot Projects; Predisposition; Psychophysiology; Publishing; Questionnaires; Reporting; Research; Risk; Risk Factors; Same-sex; Sex Differences; Structure; TMJ disk displacement; Temporomandibular Joint; Temporomandibular Joint Disorders; Testing; Time; Tissues; Translations; United States National Academy of Sciences; Work; articular cartilage; clinical practice; clinical translation; cohort; cone-beam computed tomography; cost; energy density; improved; joint loading; male; predictive marker; premature; tool

Project Summary/Abstract Temporomandibular disorders (TMDs) are prevalent, with estimates of 5% to 10%, with two-fold higher prevalence for females than males (NASEM, 2020), and projected annual costs of $4 billion (Stowell et al. 2007). TMD represents a group of conditions with and without pain, such as temporomandibular joint (TMJ) disc displacement and degenerative disease. Osseous changes are late-stage, degenerative characteristics (Farina et al. 2009; Luder 2002; Wiese et al. 2008) that tend to occur >10 years earlier in the TMJ than in other human joints. The long-term goals are to elucidate the variables responsible for precocious TMJ tissue failure and the predilection for females compared to males. TMJ tissue fatigue depends on applied mechanics and behavior; that is, magnitudes and frequencies of energy input to tissues. Published and preliminary data show that magnitudes and frequencies of energy input to TMJ tissues, quantified by Mechanobehavior Score (MBS, mJ∙%/mm3), predict longitudinal changes in TMJ structures. It was found that in 35 subjects over ≥5.3 years, TMJs where intracapsular diagnoses worsened had average MBS 8-times and 3-times greater than TMJs where diagnoses improved and remained stable, respectively. However, there are anatomical and psychophysiological variables that are more easily measured and clinically translatable. The Anatomic- Psychophysiologic Score (APS), the arithmetic product of these measures, correlated well with MBS. Therefore, the overall objective is to use an existing landmark data set from the TMJ Impact Project (Schiffman et al. 2017) to evaluate these markers (APS) to predict longitudinal changes in TMJ structures and intracapsular diagnoses over 8 years in 401 subjects (789 TMJs). The specific aims are to: (1) Determine if easily measured anatomical and psychophysiological variables predict conversion rate and direction of changes to TMJ structures associated with changes in intracapsular diagnoses, and if there are sex differences. (2) Test for sex differences in longitudinal changes in mandibular condyle volume within and between diagnostic groups. The outcomes of these specific aims will help to address the current needs identified by the National Academies of Sciences, Engineering, and Medicine 2020 consensus report for "new tools, metrics, and biomarkers to diagnose TMD and forecast their trajectory.”

项目摘要/摘要 颞下颌疾病（TMD）普遍存在，估计为5％至10％，高两个倍 女性的患病率比男性（NASEM，2020年），预计年成本为40亿美元（Stowell等人。 2007）。 TMD代表有和没有疼痛的一组条件，例如颞下颌关节（TMJ） 椎间盘位移和退化性疾病。骨变化是晚期的变性特征 （Farina等，2009; Luder 2002; Wiese等人2008）在TMJ中往往是10年前发生的 人类关节。长期目标是阐明导致早熟TMJ组织失败的变量 与男性相比，女性的预测。 TMJ组织疲劳取决于应用机制和 行为;也就是说，对组织的能量输入的磁性和频率。发布和初步数据显示 通过机械行为评分来量化的对TMJ组织的能量输入的幅度和频率 MJ∙％/mm3），预测TMJ结构的纵向变化。发现在35名超过5.3年的受试者中， 囊内诊断恶化的TMJ的平均MBS 8时间和3倍大于TMJ 诊断分别改善和保持稳定的地方。但是，有解剖学和 更容易测量和临床翻译的心理生理变量。解剖学 - 心理生理评分（APS），这些措施的算术产物与MBS良好相关。 因此，总体目标是使用TMJ Impact项目（Schiffman）的现有地标数据集 等。 2017）评估这些标记（AP）以预测TMJ结构和 401名受试者（789个TMJ）超过8年的囊内诊断。具体目的是： （1）确定是否容易测量解剖学和心理生理变量预测转化率和 与囊内诊断变化相关的TMJ结构变化的方向，以及是否存在 性别差异。 （2）测试下颌cons体和之间的下颌con纵变化的性别差异 诊断组。 这些特定目标的结果将有助于满足国家确定的当前需求 科学，工程和医学学院2020年共识报告“新工具，指标和 生物标志物诊断TMD并预测其轨迹。”