Center for the Translational Neuroscience of Alcoholism

酗酒转化神经科学中心

• 批准号: 10646261
• 负责人: John H. Krystal
• 金额: $ 174.13万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-04 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646261
• 关键词: Achievement; Address; Alcohol consumption; Alcoholic beverage heavy drinker; Alcoholism; Alcohols; Animals; Attenuated; Basic Science; Behavioral; Brain; Chemicals; Clinical; Clinical Research; Corpus striatum structure; Development; Doctor of Medicine; Education; Ethics; Faculty; Glutamate Receptor; Glutamates; Goals; Heritability; Human; Infrastructure; International; Learning; Mission; Modeling; Molecular; Molecular Genetics; N-Methylaspartate; National Institute on Alcohol Abuse and Alcoholism; Neurosciences; Neurosciences Research; Pathologic; Pilot Projects; Postdoctoral Fellow; Prevention strategy; Productivity; Psychopharmacology; Public Health; Regulation; Research; Research Personnel; Research Support; Research Training; Rewards; Risk; Scientist; Self Administration; Services; Signal Transduction; Signaling Protein; Students; Testing; Up-Regulation; alcohol research; alcohol risk; alcohol use disorder; career development; drinking; glutamatergic signaling; high risk; innovation; insight; metabotropic glutamate receptor 5; neural circuit; neurochemistry; neuroimaging; novel; preclinical study; public health relevance; success; symposium; therapeutic evaluation; translational neuroscience; translational research program

CTNA Overall John Krystal, M.D. Abstract The gap between basic research advances and new clinical insights and treatments remains a critical obstacle to progress in the field of alcoholism research. This translational neuroscience mission is the enduring focus of the Center for the Translational Neuroscience of Alcoholism (CTNA). CTNA conducts groundbreaking molecular neuroscience, molecular genetics, functional and chemical neuroimaging, and psychopharmacology studies in the service of providing new insights to bridge the gap between basic and clinical research. This renewal application will study how inhibition of mGluR5 might normalize disturbances in cortico-striatal glutamate signaling arising from upregulation of NMDA-R and, in so doing, attenuate both goal- oriented (model-based learning) and habitual (model-free learning) alcohol consumption in animals and reduce alcohol consumption in human heavy drinkers. In so doing, we propose the first translational neuroscience evaluation of the therapeutic potential of mGluR5 NAM’s, a mechanism that has received intensive preclinical study. Building upon its prior achievements, The CTNA will facilitate transdisciplinary research within projects and across projects and with other alcohol focused initiatives nationally. It will also continue its highly productive Pilot Projects Core that provides an open competitive mechanism to enable the Center to rapidly encompass innovative new research and to engage outstanding investigators new to alcoholism research. CTNA will continue to expand its educational mission, building on the success of the the International Conference on the Applications of Neuroimaging to Alcoholism.

ctna总体 约翰·克里斯塔尔（John Krystal），医学博士 抽象的 基础研究进展与新的临床见解和治疗之间的差距仍然是一个 酒精中毒研究领域进步的关键障碍。这种翻译神经科学 任务是酗酒转化神经科学中心的持久重点 （ctna）。 CTNA进行开创性的分子神经科学，分子遗传学， 功能和化学神经影像学以及心理药理学研究 提供新的见解，以弥合基础研究和临床研究之间的差距。这个更新 应用将研究MGLUR5的抑制作用如何使皮质纹状体中的疾病正常化 NMDA-R的上调引起的谷氨酸信号传导，因此，这两个目标都会减弱 定向（基于模型的学习）和习惯性（无模型学习）饮酒 动物并减少人类重饮酒者的饮酒。这样做，我们提出了 对MGlur5 Nam的治疗潜力的首次转化神经科学评估 接受密集临床前研究的机制。以先前成就为基础 CTNA将促进项目内，跨项目以及与 其他酒精集中在全国范围内。它还将继续其高产的飞行员项目 提供开放的竞争机制的核心，使中心能够快速涵盖 创新的新研究，并吸引新手的酒精中毒研究人员。 CTNA将继续扩大其教育使命，以取决于 国际神经影像在酒精中毒中的应用。

项目成果

The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.

• DOI: 10.1097/fpc.0b013e32832b9cfc
• 发表时间: 2009-06
• 期刊: Pharmacogenetics and genomics
• 影响因子: 2.6
• 作者: Zuo L;Luo X;Krystal JH;Cramer J;Charney DS;Gelernter J
• 通讯作者: Gelernter J

Dissociation of genetic and hormonal influences on sex differences in alcoholism-related behaviors.

• DOI: 10.1523/jneurosci.0548-10.2010
• 发表时间: 2010-07-07
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Barker JM;Torregrossa MM;Arnold AP;Taylor JR
• 通讯作者: Taylor JR

A preliminary investigation of varenicline for heavy drinking smokers.

• DOI: 10.1007/s00213-010-2160-9
• 发表时间: 2011-06
• 期刊: PSYCHOPHARMACOLOGY
• 影响因子: 3.4
• 作者: Fucito, Lisa M.;Toll, Benjamin A.;Wu, Ran;Romano, Denise M.;Tek, Ece;O'Malley, Stephanie S.
• 通讯作者: O'Malley, Stephanie S.

Identifying factors associated with opioid cessation in a biracial sample using machine learning.

• DOI: 10.37349/emed.2020.00003
• 发表时间: 2020
• 期刊: Exploration of medicine
• 作者: Cox JW;Sherva RM;Lunetta KL;Saitz R;Kon M;Kranzler HR;Gelernter J;Farrer LA
• 通讯作者: Farrer LA

An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate.

• DOI: 10.1016/j.euroneuro.2015.06.006
• 发表时间: 2015-10
• 期刊: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
• 作者: Gueorguieva R;Wu R;Tsai WM;O'Connor PG;Fucito L;Zhang H;O'Malley SS
• 通讯作者: O'Malley SS