UNC Chemical Biology Interface Training Program

北卡罗来纳大学化学生物学界面培训计划

• 批准号: 10646465
• 负责人: Jeffrey Aube
• 金额: $ 27.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646465
• 关键词: Biology; Chemicals; Training Programs

ABSTRACT We propose to establish a Chemistry–Biology Interface (CBI) Training Program that will enable trainees at the University of North Carolina at Chapel Hill (UNC) to obtain the breadth of scientific training essential for modern, mechanistically informed chemical biology. This program draws from two historically successful programs at UNC: the Division of Chemical Biology and Medicinal Chemistry (CBMC) in the UNC Eshelman School of Pharmacy, and the Biological and Organic Chemistry Divisions in the UNC Department of Chemistry (College of Arts and Sciences). These two units have a strong and continuing tradition of collaboration, common coursework, and a shared seminar series. Although UNC has a highly regarded scientific tradition, there is no chemistry-oriented NIH training program on the UNC campus. The proposed program will bring together 25 established researchers who encompass the breadth of chemical biology, ranging from analytical bioanalysis to protein structure/function to medicinal chemistry/drug design. In addition, three promising junior faculty members will join the program as “mentored mentors”, working closely with senior colleagues as they continue to establish their programs. The program leaders, one from CBMC and one from the Department of Chemistry, are accomplished senior faculty with mentoring and administrative experience; they will provide program guidance with input from an internal steering committee and a distinguished group of external advisors. Students will be recruited from the two primary units and from a UNC umbrella biological/biomedical sciences program that has shown remarkable success in recruiting outstanding and diverse graduate students to the campus. The training program includes (1) common coursework that establishes the basis for research at the chemistry–biology interface, including responsible conduct of research and rigor/reproducibility training, (2) biweekly meetings that alternate between a journal club and a smaller discussion group focused on individual learning and professional development, (3) an program retreat that will be held before the fall semester, providing orientation and early formal training in rigor and reproducibility, and (4) a trainee-organized symposium that will become a major annual event at UNC. Work at the chemistry–biology interface has become increasingly relevant as our understanding of biology has required more molecular insights. Accordingly, the activities of the proposed program will capitalize on the diverse expertise in CBMC and Chemistry, and the extensive educational and research resources that are available at this internationally recognized institution. This program will provide trainees with a superior education from the perspective of depth and breadth, and develop well-trained PhD scholars at the interface of chemistry and biology who will play a critical role in the biomedical sciences across academia and industry.

抽象的 我们建议建立化学生物学界面（CBI）培训计划，该计划将使受训者能够 北卡罗来纳大学教堂山（UNC）获得科学培训的广度 现代，机械知情的化学生物学。该计划从两个历史上成功 UNC的计划：UNC Eshelman的化学生物学和药物化学（CBMC） UNC化学系的药学学院以及生物学和有机化学部门 （艺术与科学学院）。这两个单元具有强大而持续的协作传统， 常见的课程工作和共享的开创性系列。尽管UNC具有备受推崇的科学传统，但 UNC校园没有以化学为导向的NIH培训计划。拟议的计划将带来 25个既定的研究人员都涵盖了化学生物学广度，从分析范围 对药物化学/药物设计的蛋白质结构/功能的生物分析。此外，三个有前途的大三 教职员工将以“导师的导师”的身份加入该计划，并与高级同事紧密合作。 继续建立他们的计划。该计划负责人，一名来自CBMC，一名来自部门 化学是具有心理和行政经验的高级教师；他们将提供 计划指导，内部指导委员会的意见和杰出的外部群体 顾问。将从两个主要单元和UNC伞生物/生物医学中招募学生 科学计划在招募杰出和多样化的研究生方面取得了巨大成功 去校园。培训计划包括（1）建立研究基础的常见课程 在化学生物学界面上，包括负责研究和严格/可重复性培训的负责任 （2）每两周举行的会议，在期刊俱乐部和一个较小的讨论小组之间进行选择 个人学习和专业发展，（3）将在秋季之前举行的计划务虚会 学期，提供严格和可重复性的定向和早期正式培训，以及（4）学员组织的 研讨会将成为UNC的重大年度活动。在化学 - 生物学界面的工作 由于我们对生物学的理解需要更多的分子见解，因此变得越来越重要。 彼此之间，拟议计划的活动将利用CBMC和 化学，以及该国际上可用的广泛的教育和研究资源 公认的机构。该计划将从 深度和广度，并在化学和生物学的界面上发展训练有素的博士学位学者 在学术界和行业的生物医学科学中发挥关键作用。