TASK ORDER 5R - PERSONALIZED ENVIRONMENT AND GENES STUDY (PEGS)

任务顺序 5R - 个性化环境和基因研究 (PEGS)

基本信息

批准号：
10641649
负责人：
JAMIE GLOVER
金额：
$ 75.95万
依托单位：
SOCIAL AND SCIENTIFIC SYSTEMS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10641649
关键词：
Address Affect Age Agriculture Air Pollution Alcohol consumption Asthma Back Biological Assay Canada Chemical Exposure Childhood Clinical Data Clinical Research Cohort Studies Collection Complex Computerized Medical Record Data Data Collection Data Scientist Denmark Diabetes Mellitus Diet Disease Education Electronic Health Record Enrollment Environment Environmental Exposure Environmental Risk Factor Ethnic Origin Etiology Exposure to Family history of Follow-Up Studies Genes Genetic Genetic Polymorphism Genetic study Genotype Geographic Information Systems Goals HLA Antigens Health Heart Diseases Home Human Hypersensitivity International International Classification of Diseases Japan Length Life Life Style Link Malignant Neoplasms Medical Medical Genetics Multiomic Data Multiple Sclerosis National Institute of Environmental Health Sciences North Carolina Occupational Exposure Participant Persons Pharmaceutical Preparations Phenotype Physical activity Population Psoriasis Race Recording of previous events Registries Research Research Personnel Resolution Rheumatoid Arthritis Risk Risk Factors Single Nucleotide Polymorphism Site Sleep Smoking Socioeconomic Status Stress Stroke Surveys System United States United States National Institutes of Health Universities Validation Variant Work analytical method base cohort demographics disorder risk gene environment interaction genetic variant genome sequencing health disparity improved interest lifestyle factors multidimensional data novel operation participant enrollment response telomere whole genome

项目摘要

The Personalized Environment and Genes Study (PEGS) is a long-term project to collect health, exposure, medical, and genetic data from a diverse group of people in North Carolina. Initiated in 2002, PEGS was formerly called the Environmental Polymorphisms Registry (EPR) and is sponsored by the National Institute of Environmental Health Sciences (NIEHS), which is part of the National Institutes of Health (NIH). A total of 19,672 participants are enrolled, and ~11,000 are actively engaged with annual contact. Enrollment of participants is ongoing. From 2013-2020, three surveys were used to collect phenotype and exposure data in the cohort. The PEGS Health and Exposure Survey (N = 9,414) collected data on general demographics, family medical history, information on lifestyle factors such as smoking and alcohol use, and data on occupational exposures. Beginning in 2017, the NIEHS PEGS Exposome Survey was administered to collect comprehensive information about endogenous and exogenous exposures throughout life. Part A is focused on external exposures, including chemical and environmental exposures at work and home from childhood to the present. Part B includes questions about internal exposures, including medications, and lifestyle factors such as physical activity, stress, sleep, and diet. In addition to the survey-based exposure data, address histories (included longest-lived childhood address) are collected. These addresses have been used to link participants with a growing list of geospatial exposure estimates, including air pollution and distance to toxic release and agricultural operation sites. In addition to the collection of extensive exposure data, whole genome sequencing (WGS) has been conducted for the 4,737 participants with the most complete exposure data. The WGS data enable genetic studies evaluating not only single nucleotide variants but also other variants comprehensively assayed by WGS, including copy number and structural variants, telomere length, and high-resolution human leukocyte antigen (HLA) complex variation. Efforts are ongoing with both the University of North Carolina at Chapel Hill (UNC) and Duke University to integrate electronic health records for PEGS participants. Together these efforts represent an unprecedented integration of medical information backed by UNC and Duke system electronic medical records (EMRs), exposure information and WGS data. International efforts such as the Tohoku Medical Megabank in Japan, multiple registries in Denmark, and CanPath in Canada have assembled extensive data within their cohorts. In the United States, however, not only is PEGS unique, but PEGS participants are also an active and engaged group. In summary, PEGS has registered 19,672 North Carolina residents and includes rapidly expanding sets of high-dimensional data that comprise: • Responses to health and exposure surveys, internal exposome surveys and external exposome surveys. • Electronic Health Records (EHRs) and Electronic Medical Records (EMRs), including International Classification of Diseases (ICD) information. • Whole genome sequencing data. • Geographic Information Systems (GIS) data.

个性化的环境和基因研究（PEGS）是一个长期项目，旨在从北卡罗来纳州的一群人群收集健康，暴露，医疗和遗传数据。 PEG始于2002年，以前被称为环境多态性注册中心（EPR），并由美国国家卫生研究院（NIH）的国家环境卫生科学研究所（NIEHS）赞助。总共有19,672名参与者，约有11,000名参与年度接触。参与者的入学率正在进行中。从2013 - 2020年开始，使用了三项调查来收集队列中的表型和暴露数据。 PEGS健康与暴露调查（n = 9,414）收集了有关一般人口统计学，家族病史，关于吸烟和饮酒等生活方式因素的信息的数据，以及有关职业暴露的数据。从2017年开始，进行了NIEHS PEGS Exposome调查，以收集有关内源性和外源性暴露的全面信息。 A部分专注于外部暴露，包括工作中的化学和环境暴露，以及从童年到现在的房屋。 B部分包括有关内部暴露的问题，包括药物和生活方式因素，例如体育锻炼，压力，睡眠和饮食。除了基于调查的暴露数据外，还收集了地址历史记录（包括最长的儿童地址）。这些地址已被用来将参与者与越来越多的地理空间暴露估计清单联系起来，包括空气污染以及与有毒释放和农业运营场所的距离。除了收集广泛的暴露数据外，还针对拥有最完整的暴露数据的4,737名参与者进行了整个基因组测序（WGS）。 WGS数据使遗传研究不仅可以评估单个核苷酸变体，而且还评估了由WGS全面分配的其他变体，包括拷贝数和结构变体，端粒长度和高分辨率人白细胞抗原（HLA）复合物。北卡罗来纳大学教堂山（UNC）和杜克大学都在努力努力，以整合PEGS参与者的电子健康记录。这些努力共同代表了由UNC和Duke系统电子病历（EMR），暴露信息和WGS数据支持的医疗信息的前所未有的整合。国际努力，例如日本的Tohoku Medical Megabank，丹麦的多个登记处以及加拿大的Canpath，在其同伙中汇集了广泛的数据。但是，在美国，PEG不仅是独一无二的，而且PEGS参与者也是一个活跃而参与的群体。总而言之，PEG已注册了19,672个北卡罗来纳州居民，包括迅速扩展的高维数据集： •对健康和暴露调查的响应，内部剥出体调查和外部剥出体调查。 •电子健康记录（EHRS）和电子病历（EMR），包括国际疾病分类（ICD）信息。 •整个基因组测序数据。 •地理信息系统（GIS）数据。