Subcortical influence on the respiratory coordination of cortical neurodynamics related to cognition

皮质下对认知相关皮质神经动力学呼吸协调的影响

基本信息

批准号：
10652899
负责人：
JAMES M MCNALLY
金额：
$ 19.62万
依托单位：
BOSTON VA RESEARCH INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10652899
关键词：
Animals Attention Behavior Brain Brain region Cell Nucleus Characteristics Cognition Cognitive Cognitive deficits Communication Conscious Coupling Cues Data Detection Development Disease Exhalation Exhibits Failure Food Frequencies Hippocampus (Brain)Impaired cognition Impairment In Vitro Inhalation Investigation Light Location Measures Mechanical Stimulation Memory Mental disorders Mus Nasal Epithelium Neurons Nose Parietal Parietal Lobe Parvalbumins Pathologic Processes Perception Performance Phase Physiology Play Protocols documentation Reaction Time Reporting Research Respiration Rewards Rodent Role Sensory Signal Transduction Stimulus Task Performances Testing Tort Training Validation Variant Visual Cortex Visual attention Work attenuation basal forebrain cognitive enhancement cognitive function disabling symptom improved neurological pathology neuropsychiatric disorder neuropsychiatry novel novel diagnostics novel therapeutic intervention olfactory bulb optogenetics relating to nervous system respiratory response sustained attention translational therapeutics vigilance way finding

Animals Attention Behavior Brain Brain region Cell Nucleus Characteristics Cognition Cognitive Cognitive deficits Communication Conscious Coupling Cues Data Detection Development Disease Exhalation Exhibits Failure Food Frequencies Hippocampus (Brain)Impaired cognition Impairment In Vitro Inhalation Investigation Light Location Measures Mechanical Stimulation Memory Mental disorders Mus Nasal Epithelium Neurons Nose Parietal Parietal Lobe Parvalbumins Pathologic Processes Perception Performance Phase Physiology Play Protocols documentation Reaction Time Reporting Research Respiration Rewards Rodent Role Sensory Signal Transduction Stimulus Task Performances Testing Tort Training Validation Variant Visual Cortex Visual attention Work attenuation basal forebrain cognitive enhancement cognitive function disabling symptom improved neurological pathology neuropsychiatric disorder neuropsychiatry novel novel diagnostics novel therapeutic intervention olfactory bulb optogenetics relating to nervous system respiratory response sustained attention translational therapeutics vigilance way finding

展开

项目摘要

Slow cortical oscillations, such as theta (5-9Hz) band activity, may provide coherence of activity over large distances, providing a mechanism for interregional communication involved in neural processing. Faster gamma band oscillations (GBO; 30-200 Hz) are thought to play a major role in higher-level cognitive processing including attention. The role of theta/GBO coupling (TG coupling) in cognitive processing is well established. However, more recent studies have observed that nasal respiration can also temporally coordinate dynamic neural activity in the brain, reflected as respiratory-entrained oscillations (REO), which exhibit high phase-amplitude coupling to GBO (RG coupling) during select behaviors. Presently it is unknown if RG coupling has a role in cognition. Our overarching hypothesis posits that the strength of RG coupling in the attention-related frontoparietal network (prelimbic and posterior parietal cortices) will correlate with attention-related performance. Aim 1: RG coupling in the frontoparietal attentional network correlates with performance in an attention-demanding operant task. We will measure respiration and REO in local field potentials in select brain regions to evaluate RG coupling during an operant signal detection task used to measure sustained attention, the rodent psychomotor vigilance task (rPVT). In the rPVT, mice maintain attention to a stimulus location, and respond to detection of a brief and unpredictable cue with a short-latency operant response to receive food reward. Prior to correct trials, we predict that RG coupling will be strong in the frontoparietal attention network, and that fast reaction times will correlate with robust RG coupling. In contrast, prior to omission trials (attention failures), we predict that RG coupling will be diminished. Aim 2: Attenuation/promotion of RG coupling by means of optogenetic manipulation of BF parvalbumin neurons (BF-PV) will impair/improve attention-related performance in the rPVT. Our preliminary findings show that closed-loop gamma frequency stimulation (CLS) of BF-PV in relation to respiratory inhalation, but not exhalation, promotes RG coupling. Therefore, we will utilize this CLS paradigm to determine how modulation of RG coupling impacts attention-related performance. Across a range of select neuropsychiatric illnesses, the pathological processes behind cognitive deficits involve abnormal neural temporal dynamics. Thus, these studies will help to inform the development of translational therapies to restore/enhance cognitive function.

缓慢的皮质振荡，例如theta（5-9Hz）频带活性，可能会在大型上提供活性的连贯性距离，提供了与神经加工有关的区域间交流的机制。快点伽马频段振荡（GBO; 30-200 Hz）被认为在高级认知中起主要作用处理包括注意。 Theta/GBO耦合（TG耦合）在认知处理中的作用很好已确立的。但是，最近的研究观察到鼻呼吸也可以在时间上暂时大脑中的坐标动态神经活动，反映为呼吸道输入的振荡（REO），该振荡（REO）在某些行为过程中表现出高相位振幅耦合与GBO（RG耦合）。目前未知如果RG耦合在认知中起作用。我们的总体假设认为RG耦合的强度与注意力有关的额叶网络（前和顶壁皮层）将与与注意力有关的表现。 AIM 1：额叶注意网络中的RG耦合与性能相关注意操作任务。我们将在选择中测量本地现场电位中的呼吸和REO 大脑区域以评估用于测量持续的操作信号检测任务期间的RG耦合注意，啮齿动物心理警惕任务（RPVT）。在RPVT中，小鼠保持对刺激的关注位置，并响应对简短且不可预测的提示的检测获得食物奖励。在正确试验之前，我们预测RG耦合在额叶中会很强注意网络，快速反应时间将与鲁棒的RG耦合相关。相反，之前遗漏试验（注意力失败），我们预测RG耦合将减少。 AIM 2：通过BF的光遗传操作衰减/促进RG耦合白蛋白神经元（BF-PV）将损害/改善RPVT中与注意力相关的性能。我们的初步发现表明，BF-PV的闭环γ频率刺激（CLS）相对于呼吸吸入（而不是呼气）促进了RG耦合。因此，我们将使用此CLS范式确定RG耦合的调制如何影响注意力相关的性能。在一系列选择的神经精神疾病中，认知缺陷背后的病理过程涉及异常的神经时间动力学。因此，这些研究将有助于告知转化疗法以恢复/增强认知功能。