Translational Research Training on Aging and Mobility (TRAM)

老龄化和流动性转化研究培训（TRAM）

基本信息

批准号：
10640928
负责人：
Todd Manini
金额：
$ 32.63万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640928
关键词：
Aging Research Training Translational Research

项目摘要

Preserved mobility is one of hallmarks of geriatric care, gerontology and geroscience. The loss of mobility with aging is progressive, caused by multiple factors and does not have a simple cure. Unfortunately, mobility loss continues to lack clinical attention, robust biomedical targets, objectively-measured surveillance systems, and effective treatments. As a result, mobility difficulties have remained persistently high and stagnant since it was systematically measured in the late 1980's. Currently, 30% of Americans aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older report difficulties with their mobility (e.g. walking and climbing stairs). To address this unmet need, we propose the Translational Research training on Aging and Mobility (TRAM) postdoctoral training program to train 4 post-doctoral fellows per year (2 in year one). The overall goal of the TRAM program is to develop outstanding independent investigators capable of sustaining productive multi-disciplinary and translational research careers addressing the multi-factorial causes and consequences of age-related changes in mobility and/or designing multi-modal interventions to prevent and rehabilitate mobility impairments in older adults. The goals are to: 1) Provide a 2-3 year integrated training program for PhD/MD fellows to create a career pathway for conducting mechanistic and clinically relevant translational research in mobility and aging; 2) Implement a cross-fertilized training program based on the Experiential Learning Theory; 3) To equip trainees with new research skills along with the knowledge and expertise to address impactful and unanswered questions regarding mobility and aging; 4) Closely monitor and track trainee-related experiences and outcomes for making continuous quality improvements; 5) Create a culture for professional excellence and development based on enhancing rigor, reproducibility and transparency in trainee-related research and; 6) To attract, recruit and enroll minorities, and those with disabilities and disadvantaged backgrounds. TRAM program faculty are collaborators on each other's projects, bring strong mentorship experience and successful commitment to research related to mobility and/or aging. Program faculty are grouped into either Aging or Mobility Research Clusters based on research focus and expertise. TRAM will use a mosaic mentoring approach that will employ dual primary mentors— one from “aging” and another from “mobility” expertise— a third mentor will serve as an advocate/sponsor. Mentees will also receive support from other archetypes like coaches, connectors and senior peer mentors. This unified mentoring team will guide trainees through an individual development plan, didactic coursework (e.g. mechanistic and clinical-based research on aging and/or mobility, ethics, responsible conduct of research), directed research training, and professional development activities (e.g. strategic planning, innovative leadership) that will be tailored according to the educational needs and research interests of the trainee. At completion, TRAM fellows will fulfill the scientific needs and grow the research workforce for meeting the growing population of mobility impaired older adults.

保留的移动性是老年护理，老年科学和Geroscience的标志。衰老是渐进的，是由多种因素引起的，没有简单的治疗方法。继续缺乏临床治疗，健壮的生物医学目标，客观的监视系统以及有效治疗。在1980年代后期，有30％的美国人在1980年代后期进行测量 70-79和55％的个人在80岁或以上的个人报告差异（例如步行和攀登）楼梯）。（TRAM）培训4个博士后研究员的培训计划（第一年的2个）电车计划的旨在培养能够维持生产力的杰出独立研究人员跨学科和转化研究职业，涉及多因素原因和同意与年龄相关的移动性和/或设计多模式干预措施以预防和可重用的活动性老年人的障碍是：1）提供2 - 3年的综合培训计划研究员创造了一个职业途径，用于解决机械和临床相关的翻译研究移动性和老化； 3）为培训提供新的研究技能，并拥有知识和专业知识，以解决影响力和未解决的问题认为移动性和老化；并取得持续的质量改进； 5）以及基于增强严格，繁殖和透明性研究的开发以及； 6）吸引，招募和招募少数群体，以及那些不知所措和背景的人计划教师是彼此项目的合作者，带来丰富的指导经验和成功对与流动性和/或老化有关的研究的承诺。基于研究重点和专业知识的流动性研究集群将使用马赛克指导 Willoy双主要导师的方法 - 一个来自“烦恼”，另一个来自“流动性”专业知识第三名导师将担任Asvocate/Sponsor。教练，连接器和高级同行导师。个人发展计划，教学课程（例如，基于机械和临床的衰老研究和/或流动性，道德规范，负责任的研究，指导研究培训和专业开发活动（例如战略规划，创新领导），将量身定制学员的教育需求和研究兴趣。需要并增加研究人员，以满足不断增长的流动性损害老年人的人口。