Biomarker Core

生物标志物核心

• 批准号: 10641039
• 负责人: JOSEPH F QUINN
• 金额: $ 9.22万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641039
• 关键词: Address; Age-associated memory impairment; Aged, 80 and over; Algorithms; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Amyloid beta-Protein; Apolipoprotein E; Area; Award; Behavior monitoring; Biological Markers; Blood; Blood specimen; Clinical; Collaborations; DNA; Data; Dementia; Development; Disease; Disease Progression; Education; Elderly; Fostering; Funding; Genetic; Genetic Risk; Genotype; Goals; Grant; Growth; Home; Image; Knowledge; Measurement; Measures; Mission; Monitor; Names; Neurodegenerative Disorders; Omega-3 Fatty Acids; Oregon; Peptides; Peripheral; Plasma; Practice Guidelines; Productivity; Protocols documentation; Publishing; RNA; Reagent; Research; Research Peer Review; Research Personnel; Research Support; Sampling; Single Nucleotide Polymorphism; Site; Specimen; Standardization; Structure; Technology; Testing; United States National Institutes of Health; Work; aging brain; biomarker development; cohort; cooperative study; data sharing; experience; extracellular; improved; innovation; microRNA biomarkers; mild cognitive impairment; neuroimaging; neuropathology; new technology; novel; pre-clinical; prospective; repository; sample collection; tau Proteins; tau-1; vascular factor

Project Summary: Biomarker Core The Biomarker Core is aligned to support the overall goals of the OADRC: To provide a structure and forum to foster and develop new and innovative research in brain aging and the dementias, and to facilitate collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the Alzheimer’s Consortium Treatment Consortium, the National Centralized Repository for Alzheimer’s Disease and Related Dementias, and many other relevant outside research groups. The mission of the OADRC’s Biomarker Core is to improve and maximize the quality and availability of biomarker samples and information for research. It is organized to support current research, and to anticipate future research requirements made possible by new knowledge and new technologies. The Specific Aims of the Biomarker Core are as follows: 1) To obtain and make available for research, biomarker specimens (DNA, plasma, and CSF) from OADRC subjects, including healthy control subjects, subjects with mild cognitive impairment (MCI), and subjects with AD and other dementias. 2) To obtain and make available for research, biomarker data on OADRC subjects. This will include: a) apolipoprotein E (ApoE) genotype on all subjects, b) single nucleotide polymorphism (SNP) profiles on select cohorts, c) genetic risk scores on select cohorts, and d) CSF Abeta, tau, and ptau values for OADRC subjects who donate CSF for research. 3) To foster collaborative research involving biomarkers and neurodegenerative disease. The areas of emphasis for the OADRC have been described in the overview as (a) Preclinical dementia and activity of disease emphasizing the oldest old; (b) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (c) Neuropathology of brain aging and late life dementia; (d) Novel testing of novel treatments; and (e) Improving education and sharing knowledge about dementia. These areas will be priorities for the Core to support in collaborative work. In addition, the OADRC recognizes a responsibility to support all NIH- funded and comparably peer-reviewed research whenever possible.

项目摘要：生物标记核心 生物标记核心旨在支持 OADRC 的总体目标： 提供一个结构和论坛 促进和发展脑衰老和痴呆症方面的新的和创新的研究，并促进 与其他阿尔茨海默病的合作研究、科学互动和数据共享传输 中心、国家阿尔茨海默病协调中心、阿尔茨海默病合作研究单位、 阿尔茨海默病治疗联盟、国家阿尔茨海默病集中存储库 和相关痴呆症，以及许多其他相关的外部研究小组。 OADRC 生物标志物核心的使命是提高和最大限度地提高生物标志物的质量和可用性 它的组织目的是支持当前的研究并预测。 新知识和新技术使未来的研究需求成为可能。 生物标志物核心如下： 1) 获取生物标志物样本（DNA、血浆和脑脊液）并用于研究 OADRC 受试者，包括健康对照受试者、患有轻度认知障碍 (MCI) 的受试者，以及 患有 AD 和其他痴呆症的受试者。 2) 获取 OADRC 受试者的生物标志物数据并供研究使用，这将包括： a) 所有受试者的载脂蛋白 E (ApoE) 基因型，b) 单核苷酸多态性 (SNP) 谱 选择队列，c) 选择队列的遗传风险评分，以及 d) CSF Abeta、tau 和 ptau 值 捐赠脑脊液用于研究的 OADRC 受试者。 3) 促进涉及生物标志物和神经退行性疾病的合作研究。 OADRC 的重点在概述中被描述为 (a) 临床前痴呆和活动 (b) 通过研究捕获有意义的变化的标志 外周生物标志物、神经影像学和持续的家庭行为监测 (c) 脑老化和晚年痴呆的神经病理学；(d) 新疗法的新测试；以及 (e) 改善痴呆症的教育和分享知识将是核心的优先事项。 此外，OADRC 认识到支持所有 NIH 的责任。 尽可能资助并经过同行评审的研究。