Oregon Alzheimer's Disease Research Center

俄勒冈阿尔茨海默病研究中心

• 批准号: 10641023
• 负责人: Miranda M Lim
• 金额: $ 303万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641023
• 关键词: Address; Aged, 80 and over; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Behavior monitoring; Biochemical; Biological; Biological Markers; Clinical; Collaborations; Communities; Data; Dementia; Disease; Early Diagnosis; Education; Elderly; Ensure; Environment; Family; Family member; Goals; Home; Impaired cognition; Infrastructure; Knowledge; Methods; Oregon; Participant; Patients; Peripheral; Research; Research Infrastructure; Research Support; Science; Scientist; Specimen; Technology; Testing; Training and Education; Translating; aging brain; brain tissue; collaborative environment; community engagement; education research; effective therapy; empowerment; improved; innovation; insight; interest; meetings; multidisciplinary; neuroimaging; neuropathology; novel; pre-clinical; prevent; programs; tissue resource; tool; volunteer

Project Summary: Overall The overarching goal of the Oregon Alzheimer’s Disease Research Center (OADRC) is twofold: (1) to focus on early detection of change in order to define mechanisms supporting healthy brain aging and the transition to MCI and early dementia, and (2) to facilitate developing effective therapies to prevent or limit these transitions. To achieve these objectives, eight cores and a Research Education Component are organized to catalyze and sustain innovative research and discovery in Alzheimer Disease and related dementias (ADRD) through an organizational infrastructure that supports a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. The OADC provides the necessary materials to support research through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. The OADRC focuses on specific areas of emphasis: 1) Preclinical dementia and activity of disease emphasizing the oldest old; 2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; 3) Neuropathology of brain aging and late life dementia; 4) Novel testing of novel treatments, and 5) Improving education and sharing knowledge about dementia. To attain these goals and objectives, the OADRC Specific Aims are to: 1. Catalyze and sustain innovative research and discovery in Alzheimer Disease and related disorders through an organizational infrastructure supporting a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. 2. Focus the innovation and discovery infrastructure of the center toward specific areas of emphasis: (1) Preclinical dementia and activity of disease emphasizing the oldest old; (2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (3) Neuropathology of brain aging and late life dementia; (4) Novel testing of novel treatments; and (5) Improving education and knowledge about dementia. 3. Provide the necessary materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. 4. Contribute to the national research commons relevant to Alzheimer’s disease and related disorders. 5. Provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders such as clinicians, patients and diverse family members to address the challenges of dementia.

项目摘要：总体 俄勒冈州阿尔茨海默氏病研究中心（OADRC）的总体目标是双重的：（1）专注于 早期发现变化以定义支持健康大脑衰老的机制，并过渡到 MCI和早期痴呆症，以及（2）促进开发有效的疗法以防止或限制这些过渡。 为了实现这些目标，组织了八个核心和一个研究教育部分，以催化和 通过 组织基础设施，支持由领先优势组成的丰富协作环境 技术和方法，多学科科学家，有能力的研究志愿者以及受启发的 外行和专业利益相关者社区。 OADC提供了支持的必要材料 通过特征良好的研究参与者，生物标本，脑组织，数据提供的研究 和分析。 OADRC专注于重点的特定领域：1）临床前痴呆和活动 强调最古老的疾病； 2）通过研究捕获的有意义的变化标记 生物标志物，神经成像和持续的家庭行为监测； 3）大脑衰老的神经病理学 和晚年痴呆症； 4）新型治疗方法的新颖测试，5）改善教育和共享知识 关于痴呆。 为了实现这些目标和目标，OADRC具体的目的是： 1。通过 一个支持丰富协作环境的组织基础设施，由领先优势组成 技术和方法，多学科科学家，有能力的研究志愿者以及受启发的 外行和专业利益相关者社区。 2。将中心的创新和发现基础设施集中在特定的重点领域：（1） 临床前痴呆症和疾病的活性强调了最古老的痴呆症； （2）有意义的变化标记 通过研究周围生物标志物，神经影像和连续的室内行为捕获 监视； （3）大脑衰老和晚期痴呆的神经病理学； （4）新型治疗的新型测试； （5）改善有关痴呆症的教育和知识。 3。提供必要的材料来通过良好的研究参与者来支持科学， 生物标本，脑组织，数据提供和分析。 4。为与阿尔茨海默氏病和相关疾病有关的国家研究共享贡献。 5。提供新科学家教育和培训的场所和机制，以及教育和教育 告知主要利益相关者，例如临床医生，患者和潜水员家庭成员，以解决 痴呆症的挑战。