Computational and electrochemical substrates of social decision-making in humans

人类社会决策的计算和电化学基础

基本信息

批准号：
10640947
负责人：
Xiaosi Gu
金额：
$ 99.64万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640947
关键词：
Action Potentials Affect American Psychiatric Association Antisocial Personality Disorder Attention deficit hyperactivity disorder Behavior Behavioral Brain Catecholamines Cognition Collaborations Computer Models Conscious Consensus Corpus striatum structure Decision Making Deep Brain Stimulation Detection Diagnostic Disease Dopamine Drug Addiction Electrodes Emotional Emotions Essential Tremor Failure Functional disorder Goals Health Human Injury Interpersonal Relations Investments Joints Learning Machine Learning Major Depressive Disorder Measurement Measures Mental Depression Mental disorders Methodology Methods Modeling Moods Neuromodulator Neurotransmitters Norepinephrine Obsessive-Compulsive Disorder Operative Surgical Procedures Parkinson Disease Pathologic Patients Perception Persons Play Positive Valence Research Domain Criteria Rewards Risk Role Safety Serotonergic System Serotonin Signal Transduction Site Social Interaction Social Perception Social Processes System Time Ventral Striatum Withdrawal Work arm autism spectrum disorder cognitive function diagnostic criteria dopamine system human model implantation information processing mental state neural neurochemistry neuroregulation novel psychologic putamen social social communication social deficits social norm social relationships

项目摘要

SUMMARY Dopamine and serotonin systems in the human brain represent two key neuromodulatory signalling systems that impact mood, value-based decision-making, learning, and a host of other cognitive functions. Despite their importance, there is no consensus view from a psychological or computational perspective concerning their exact information-processing functions. Consequently, there is a scarceness of strategies to treat disorders that afflict these systems. We believe that this gap exists primarily because of methodological limitations. While there are many fast methods for recording action potential activity and local field potentials, similar progress for tracking `the other end of the problem' - neurochemical dynamics - has lagged far behind. This is unfortunate since just considering the catecholamines dopamine, serotonin, and norepinephrine, the worldwide health burden of dysfunction in these neuromodulatory systems is immense approaching 400 million people worldwide if one includes just Major Depression and Attention-deficit hyperactivity disorders (WHO, 2017). The overall goal of this project is to investigate the computational and neuromodulatory substrates of interactive social processes hypothesized to be trans-diagnostic RDoC constructs. We will utilize two levels of analysis (molecules/circuits and behavioral/computational) across two RDoC constructs (systems for social processes: perception and understanding of others, subconstruct understanding mental states, and positive valence systems: reward learning, subconstruct reward prediction error) to make inroads into understanding the computational and neural underpinnings of social interaction in humans. Crucially, the interactive social tasks used in this proposal generate an important class of learning signal – a reward prediction error signal – but expressed in the context of an inter-personal interaction. Our two levels of analysis employ (1) computational models of human (two-agent) social exchange estimated from detailed, observed behavior and (2) unique sub- second measurements of dopamine and serotonin from human striatum (three separate sites: caudate, putamen, ventral striatum) during the window-of-opportunity afforded by deep brain stimulating (DBS) electrode implantation surgery for Parkinson's Disease, Essential Tremors, Obsessive Compulsive Disorder.

概括人脑中的多巴胺和5-羟色胺系统代表两个关键的神经调节信号传导系统影响情绪，基于价值的决策，学习和许多其他认知功能。尽管他们重要的是，从心理或计算的角度看不到共识的观点确切的信息处理功能。因此，有稀缺的策略来治疗疾病折磨这些系统。我们认为，由于方法上的局限性，这一差距存在主要。那里是否有许多用于记录动作潜在活动和局部现场电位的快速方法，跟踪类似的进展 “问题的另一端”（神经化学动力学）远远落后。这是不幸的，因为考虑到儿茶酚胺多巴胺，5-羟色胺和去甲肾上腺素，全球健康伯恩这些神经调节系统的功能障碍在全球范围内接近4亿人仅包括严重的抑郁症和注意力不足的多动症（WHO，2017年）。该项目的总体目标是研究交互式的计算和神经调节底物被认为是跨诊断RDOC结构的社会过程。我们将利用两个级别的分析（分子/电路和行为/计算）跨两个RDOC结构（社交系统过程：对他人的看法和理解，理解心理状态和积极价系统：奖励学习，子构建奖励预测错误）使人进入理解人类社会互动的计算和神经基础。差异，互动社会此提案中使用的任务产生了重要的学习信号 - 奖励预测错误信号 - 但在人际关系互动的背景下表示。我们的两个分析级别员工（1）计算根据详细的，观察到的行为和（2）独特的子 - 人纹状体的多巴胺和5-羟色胺的第二个测量通风纹状体）在大脑刺激（DBS）电极提供的大脑窗口窗口中帕金森氏病，基本震颤，强迫症的植入手术。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Time perception reflects individual differences in motor and non-motor symptoms of Parkinson's disease.

时间感知反映了帕金森病运动和非运动症状的个体差异。

DOI：
10.1016/j.parkreldis.2023.105800
发表时间：
2023
期刊：
Parkinsonism & related disorders
影响因子：
4.1
作者：
DiMarco,EmilyK;Sadibolova,Renata;Jiang,Angela;Liebenow,Brittany;Jones,RachelE;Haq,IhtshamU;Siddiqui,MustafaS;Terhune,DevinB;Kishida,KennethT
通讯作者：
Kishida,KennethT

Emotional adaptation during a crisis: decline in anxiety and depression after the initial weeks of COVID-19 in the United States.

DOI：
10.1038/s41398-021-01552-y
发表时间：
2021-08-20
期刊：
Translational psychiatry
影响因子：
6.8
作者：
Shuster A;O'Brien M;Luo Y;Berner LA;Perl O;Heflin M;Kulkarni K;Chung D;Na S;Fiore VG;Gu X
通讯作者：
Gu X

Humans use forward thinking to exploit social controllability.