Establishing the Influences of Childhood Trauma and Adolescent Alcohol Binge Exposures on Reward Functioning Among Young Adult Drinkers

确定童年创伤和青少年酗酒对年轻成年饮酒者奖励功能的影响

基本信息

批准号：
10455435
负责人：
Hanaan Bing-Canar
金额：
$ 3.87万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2023-05-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10455435
关键词：
Address Adolescence Adolescent Adolescent and Young Adult Affect Alcohol Phenotype Alcohol consumption Alcohols Anhedonia Animals Behavioral Characteristics Chronic Disease Clinical Cues Data Development Disease Early-life trauma Ethanol Etiology Exhibits Exposure to Frequencies Funding Goals Human Individual Joints Knowledge Laboratories Life Light Link Maintenance Measures Mentorship Modeling Motivation National Institute on Alcohol Abuse and Alcoholism Neurobiology Patient Self-Report Patients Phenotype Physiological Population Process Property Psychopathology Psychophysiology Recording of previous events Research Research Personnel Rewards Risk Robin bird Sampling Statistical Methods Stress Symptoms System Techniques Testing Training Translating Trauma adolescent binge drinking adolescent substance use alcohol abuse therapy alcohol effect alcohol exposure alcohol measurement alcohol related consequences alcohol response alcohol reward alcohol seeking behavior alcohol use disorder career chronic alcohol ingestion clinically relevant comorbidity depressive symptoms design disorder risk early life exposure early life stress emerging adult emerging adulthood experience hedonic high risk indexing multimodality neural circuit neuroadaptation pediatric trauma recruit response reward processing social social defeat statistical learning stressor theories translational model trauma exposure traumatic stress young adult

项目摘要

Project Title: Establishing the Influences of Childhood Trauma and Adolescent Alcohol Binge Exposures on Reward Functioning Among Young Adult Drinkers Project Summary/Abstract: Deficits in reward functioning, including both overvaluation of alcohol rewards and devaluation of non-alcohol rewards, are central to empirically supported models of alcohol use disorder (AUD) etiology and maintenance. Emerging adulthood represents a sensitive risk period for the development of AUD symptoms, particularly among individuals with early life exposures to stress (e.g., childhood trauma) and alcohol. Animal studies support a causal link between early trauma and alcohol exposures and deficits in reward functioning; however, translational human laboratory models are limited. The specific aims of the study are to 1a) investigate differences in subjective and physiological (i.e., corrugator and zygomaticus fEMG) responses to social (i.e., non-alcohol) reward as a function of childhood trauma (CT) and/or adolescent alcohol binge exposures, 1b) evaluate differences in subjective and physiological responses to alcohol reward as a function of CT and/or adolescent alcohol binge exposures, 2) understand alcohol reward response in the context of social reward response, and 3) identify clinical correlates of alcohol and social reward response, with regard to current measures of alcohol (e.g., binge frequency, alcohol drinking motives, alcohol-related consequences) and psychiatric risk (e.g., anhedonia, depressive symptoms). To address these aims, the current study will recruit a sample (N = 100) of young adult drinkers to examine the unique and combined influence of CT and adolescent binge histories on self-report, behavioral, and physiological indices of social (i.e., non-alcohol) and alcohol reward functioning among a population at high-risk for AUD. These study aims will facilitate the primary training goals to 1) develop an understanding of the assessment and interpretation of alcohol-related phenotypes in adolescents and young adults, 2) acquire training in and knowledge of human laboratory models of reward functioning in AUD, 3) obtain clinical training in the assessment and treatment of AUD and comorbid conditions, and 4) gain training in advanced statistical methods. Mentorship provided by experts in human laboratory models of trauma and alcohol use, adolescent substance use risk, and psychophysiology of reward response will advance the candidate’s goals to expand her experience in measurement of alcohol-related phenotypes, human laboratory models of reward processing, and translational models of AUD. Ultimately, the proposed training and research plans will support the candidate’s long-term goal of pursuing a career as a NIAAA-funded independent investigator focused on understanding the interplay between stress and alcohol phenotypes in high-risk young adult populations. The proposed study will be one of the first to evaluate the joint impact of CT and adolescent binge drinking on reward functioning in an effort to inform an integrative model of how these experiences contribute to alterations in hedonic responding and associated AUD risk in young adulthood. This project is directly in line with the NIAAA Strategic Objectives to “study how alcohol affects neural circuits involved in reward.”

项目名称：确定童年创伤和青少年酗酒对健康的影响奖励在年轻饮酒者中发挥作用项目摘要/摘要：奖励功能缺陷，包括对酒精奖励的高估和非酒精奖励的贬值是酒精使用障碍（AUD）经验支持模型的核心病因学和维持期是 AUD 发生的敏感风险期。症状，特别是在早年经历过压力（例如童年创伤）和酒精的个体中。动物研究支持早期创伤与酒精暴露和奖励缺陷之间存在因果关系然而，转化人类实验室模型的具体目的是有限的。 1a) 研究主观和生理（即皱眉肌和颧肌 fEMG）反应的差异社会（即非酒精）奖励作为童年创伤（CT）和/或青少年酗酒的函数暴露，1b）评估奖励酒精的主观和生理反应的差异作为 CT 和/或青少年酗酒暴露，2) 了解社交背景下的奖励性酒精反应奖励反应，3）确定酒精和社会奖励反应的临床相关性，就当前而言酒精测量（例如暴饮暴食频率、饮酒动机、酒精相关后果）以及精神风险（例如快感缺失、抑郁症状）。为了实现这些目标，当前的研究将招募年轻成年饮酒者样本（N = 100），以检验 CT 和青少年的独特和综合影响关于社交（即非酒精）和酒精的自我报告、行为和生理指标的狂饮历史 AUD 高风险人群的奖励功能这些研究目标将促进初级培训。目标是 1) 了解酒精相关表型的评估和解释青少年和年轻人，2) 获得人类实验室奖励模型的培训和知识在 AUD 中发挥作用，3) 获得评估和治疗 AUD 及合并症的临床培训， 4) 获得人体实验室模型专家提供的高级统计方法培训。创伤和酒精使用、青少年物质使用风险以及奖励反应的心理生理学将候选人的目标是提高她在测量酒精相关表型、人类奖励处理的实验室模型和 AUD 的转化模型最终，建议的培训和。研究计划将支持候选人追求 NIAAA 资助的独立职业生涯的长期目标研究人员专注于了解高危年轻人压力和酒精表型之间的相互作用拟议的研究将是第一个评估 CT 和青少年的联合影响的研究之一。酗酒对奖励功能的影响，旨在为这些体验的综合模型提供信息有助于改变青年期的享乐反应和相关的 AUD 风险。直接符合 NIAAA 的战略目标，即“研究酒精如何影响涉及神经回路的神经回路”。报酬。”