Cooperative Research Center for NanoScaffold-Based Chlamydia trachomatis Vaccines - Admin Core

基于纳米支架的沙眼衣原体疫苗合作研究中心 - 管理核心

基本信息

批准号：
10458650
负责人：
Matthew Adrian Coleman
金额：
$ 28.61万
依托单位：
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-08 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10458650
关键词：
Address Advisory Committees Affect Area Award Blindness Budgets California Chlamydia trachomatis Communication Data Development Discipline Ectopic Pregnancy Ensure Funding Goals Grant Health Infection Infertility Institutes Laboratories Leadership Monitor National Institute of Allergy and Infectious Disease Pathogenesis Pelvic Inflammatory Disease Persons Progress Reports Research Research Personnel Research Project Grants Scientist Sexually Transmitted Diseases Site Supervision Talents Technology Training United States United States National Institutes of Health Universities Vaccines Work base chronic abdominal pain cost data sharing long-term sequelae meetings member nano new technology novel vaccines outreach pathogenic bacteria programs recruit research and development scaffold web site

Address Advisory Committees Affect Area Award Blindness Budgets California Chlamydia trachomatis Communication Data Development Discipline Ectopic Pregnancy Ensure Funding Goals Grant Health Infection Infertility Institutes Laboratories Leadership Monitor National Institute of Allergy and Infectious Disease Pathogenesis Pelvic Inflammatory Disease Persons Progress Reports Research Research Personnel Research Project Grants Scientist Sexually Transmitted Diseases Site Supervision Talents Technology Training United States United States National Institutes of Health Universities Vaccines Work base chronic abdominal pain cost data sharing long-term sequelae meetings member nano new technology novel vaccines outreach pathogenic bacteria programs recruit research and development scaffold web site

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项目摘要

PROJECT SUMMARY/ABSTRACT Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection (STI), affecting over 130 million people every year, and is the most common cause of preventable blindness worldwide. In the United States, STIs caused by C. trachomatis account for billions of dollars in annual costs. Because the infection can be asymptomatic, it may go untreated for years and can result in long-term sequelae, including pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy, and infertility. Ct is an intracellular bacterial pathogen widespread throughout the world. In order to address the critical need for a C. trachomatis vaccine, the Administrative Core will be responsible for managing, coordinating, monitoring overall progress, and supervising the entire range of the center's activities, including the Developmental Research Program (DRP). This will involve coordination of work between three primary sites: LLNL, UCI and UCD with an emphasis on developing young scientist and novel technologies to mitigate health effects associated with C. trachomatis. The Core will focus on the following four areas: 1) Provide coordination to facilitate interactions among the CRC Project PIs and Core Directors. 2) To ensure internal data sharing and an external site for scientific outreach. 3) Establish and administrate the Developmental Research Program. 4) Evaluate the Center's progress utilizing internal and external advisory reviews.

项目摘要/摘要沙眼衣原体（CT）是最常见的细菌性传播感染（STI），每年影响超过1.3亿人，这是可预防的最常见原因全球盲目。在美国，由C. c. trachomatis造成的性传播感染占数十亿美元年度费用。因为感染可能是无症状的，所以它可能没有治疗多年并可能导致长期后遗症，包括骨盆炎性疾病，慢性腹部疼痛，异位妊娠和不育。 CT是一种细胞内的细菌病原体全世界。为了解决对沙眼梭状芽胞盘疫苗的关键需求，行政核心将负责管理，协调，监视整体监控进步并监督中心活动的整个范围，包括发展研究计划（DRP）。这将涉及三个主要站点之间的工作协调： LLNL，UCI和UCD着重于发展年轻科学家和新颖技术减轻与沙眼梭状芽孢杆菌相关的健康影响。核心将重点关注以下四个区域：1）提供协调以促进CRC项目和核心之间的相互作用导演。 2）确保内部数据共享和科学外展的外部站点。 3）建立和管理发展研究计划。 4）评估中心的利用内部和外部咨询评论的进步。