Cooperative Research Center for NanoScaffold-Based Chlamydia trachomatis Vaccines - Admin Core

基于纳米支架的沙眼衣原体疫苗合作研究中心 - 管理核心

• 批准号: 10223110
• 负责人: Matthew Adrian Coleman
• 金额: $ 26.54万
• 依托单位: UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-08 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223110
• 关键词: Address; Advisory Committees; Affect; Area; Award; Biological; Blindness; Budgets; California; Chlamydia trachomatis; Communication; Data; Development; Discipline; Ectopic Pregnancy; Ensure; Funding; Goals; Grant; Health; Infection; Infertility; Institutes; Laboratories; Leadership; Monitor; National Institute of Allergy and Infectious Disease; Pathogenesis; Pelvic Inflammatory Disease; Persons; Progress Reports; Research; Research Personnel; Research Project Grants; Scientist; Sexually Transmitted Diseases; Site; Supervision; Talents; Technology; Training; United States; United States National Institutes of Health; Universities; Vaccines; Work; base; chronic abdominal pain; cost; data sharing; meetings; member; nano; new technology; novel vaccines; outreach; pathogenic bacteria; programs; recruit; research and development; scaffold; web site

PROJECT SUMMARY/ABSTRACT Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection (STI), affecting over 130 million people every year, and is the most common cause of preventable blindness worldwide. In the United States, STIs caused by C. trachomatis account for billions of dollars in annual costs. Because the infection can be asymptomatic, it may go untreated for years and can result in long-term sequelae, including pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy, and infertility. Ct is an intracellular bacterial pathogen widespread throughout the world. In order to address the critical need for a C. trachomatis vaccine, the Administrative Core will be responsible for managing, coordinating, monitoring overall progress, and supervising the entire range of the center's activities, including the Developmental Research Program (DRP). This will involve coordination of work between three primary sites: LLNL, UCI and UCD with an emphasis on developing young scientist and novel technologies to mitigate health effects associated with C. trachomatis. The Core will focus on the following four areas: 1) Provide coordination to facilitate interactions among the CRC Project PIs and Core Directors. 2) To ensure internal data sharing and an external site for scientific outreach. 3) Establish and administrate the Developmental Research Program. 4) Evaluate the Center's progress utilizing internal and external advisory reviews.

项目概要/摘要 沙眼衣原体 (Ct) 是最常见的细菌性传播感染 (STI)， 每年影响超过 1.3 亿人，是可预防疾病的最常见原因 全世界失明。在美国，由沙眼衣原体引起的性传播感染占数十亿 美元的年度成本。由于感染可能无症状，因此可能多年未得到治疗 并可能导致长期后遗症，包括盆腔炎、慢性腹部疾病 疼痛、宫外孕和不孕症。 Ct是一种广泛存在的细胞内细菌病原体 全世界。为了满足对沙眼衣原体疫苗的迫切需求， 行政核心将负责管理、协调、监控整体 进展，并监督中心的全部活动，包括发展 研究计划（DRP）。这将涉及三个主要站点之间的工作协调： LLNL、UCI 和 UCD 重点培养年轻科学家和新技术 减轻与沙眼衣原体相关的健康影响。核心区将重点关注以下四个方面 领域： 1) 提供协调以促进 CRC 项目 PI 和核心之间的互动 董事们。 2) 确保内部数据共享和科学推广的外部网站。 3） 建立和管理发展研究计划。 4) 评估中心的 利用内部和外部咨询审查取得进展。