MDIBL Symposium on Stem Cells and Aging

MDIBL干细胞与衰老研讨会

• 批准号: 10459346
• 负责人: IAIN A. DRUMMOND
• 金额: $ 2.5万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459346
• 关键词: Address; Age; Aging; Animals; Area; Atmosphere; Biological; Blood Cells; Brain; Caloric Restriction; Cell Communication; Cells; Cellular Metabolic Process; Collaborations; Communities; DNA Damage; Discipline; Engineering; Epigenetic Process; Equilibrium; Faculty; Failure; Fishes; Generations; Genetic Transcription; Human; Immersion; Inflammation; Inflammatory; Injury; Island; Knowledge; Laboratories; Longevity; Lung; Maine; Maintenance; Medical center; Mus; Muscle; Mutation; Organ; Organ failure; Outcome; Pathology; Postdoctoral Fellow; Regenerative research; Rejuvenation; Research; Research Institute; Research Personnel; Scientific Advances and Accomplishments; Scientist; Series; Signal Transduction; Skin; Stem Cell Research; System; The Jackson Laboratory; Tissues; Training; aged; base; career; comparative; fly; graduate student; innovation; meetings; novel strategies; posters; programs; regenerative biology; research study; stem cell aging; stem cell niche; stem cell self renewal; stem cells; symposium; tissue regeneration; tissue stem cells

Abstract The Mount Desert Island Biological Laboratory (MDIBL), in collaboration with The Jackson Laboratory, and the Maine Medical Center Research Institute, proposes a conference series on "Stem Cells and Aging" to be held annually in July of 2020, 2021, and 2022 at MDIBL with the support of the NIA. This conference builds on a strong tradition of stem cell conferences at MDIBL that were first offered in 2002. The proposed series for 2020- 2022 will focus on stem cells and aging, addressing questions related to the causes of aging-associated failure of stem cell quiescence and activation, the impact of stem cell-extrinsic versus stem cell-intrinsic mechanisms in aging associated dysregulation, and new approaches to delay aging by stabilizing stem cell quiescence or reducing stem cell vulnerability. This conference will be followed by a two-week course at MDIBL "iCARB: Immersion in Comparative Aging and Regenerative Biology" that trains graduate students, postdoctoral fellows, and career scientists to become leaders in Aging and Regeneration research. The Organizing Committee, made up of national leaders in biomedical and stem cell research, has developed the program of this symposium to address current issues important to both the stem cell and aging research communities. The specific aims of the 2020 symposium are: 1) Present and discuss research studies of aging related pathologies that impact stem cells and regeneration including DNA damage / mutation, inflammation, altered cell metabolism / ROS generation, and aging-related changes in stem cell quiescence; 2) Present and discuss scientific advances defining cell-intrinsic and -extrinsic mechanisms governing stem cell aging including transcriptional programs, epigenetic programs, niche cell communication, and niche composition; 3) Present and discuss research on comparative aspects of aging (human, mouse, fish, worm, fly) with a focus on broadly conserved cellular changes in aging; 4) Present and discuss research on promoting stem cell-based tissue regeneration and rejuvenation in aging including studies of caloric restriction and stem cells, inflammatory signaling in aged stem cells, and niche engineering; and 5) Provide extensive opportunities for interaction between trainees, investigators new to stem cell research, and investigators well established in these research areas. Scientific sessions will include platform presentations, poster sessions, and a trainee/faculty networking lunch.

抽象的 荒岛山生物实验室（MDIBL）与杰克逊实验室合作， 缅因州医学中心研究所，提议将举行有关“干细胞和衰老”的会议系列 在NIA的支持下，每年在2020年7月，2021年和2022年在MDIBL。这次会议建立在 在2002年首次提供的MDIBL干细胞会议的强烈传统。拟议的系列2020- 2022将专注于干细胞和衰老，解决与衰老相关失败原因有关的问题 干细胞的静止和激活，干细胞 - 超支与干细胞中性机制的影响 与老化相关的失调，以及通过稳定干细胞静止或 减少干细胞脆弱性。此会议将在MDIBL“ ICARB： 沉浸在比较衰老和再生生物学中”，训练研究生，博士后研究员， 和职业科学家成为衰老和再生研究领域的领导者。组织委员会成立 在生物医学和干细胞研究领域的国家领导者的领导者中，已经开发了该研讨会的计划 解决当前对干细胞和衰老研究社区重要的问题。特定目标 2020年研讨会是：1）提出并讨论有关影响茎的衰老相关病理的研究 细胞和再生，包括DNA损伤 /突变，炎症，细胞代谢改变 / ROS改变 干细胞静止的产生和与衰老有关的变化； 2）出席和讨论科学进步 定义有关干细胞衰老的细胞中性和 - 肢体机制，包括转录程序， 表观遗传程序，利基细胞通信和利基组成； 3）提出并讨论有关的研究 衰老的比较方面（人，小鼠，鱼类，蠕虫，蝇），重点是宽阔的细胞变化 在衰老中； 4）提出并讨论有关促进基于干细胞的组织再生和复兴的研究 衰老，包括对热量限制和干细胞的研究，老年干细胞的炎症信号传导和利基市场 工程; 5）为学员之间的互动提供了广泛的机会，STEM的调查人员 细胞研究和研究人员在这些研究领域已建立了良好的建立。科学会议将包括平台 演讲，海报会议和实习生/教师网络午餐。