Comparative Biology of Tissue Repair, Regeneration and Aging

组织修复、再生和衰老的比较生物学

• 批准号: 10437777
• 负责人: IAIN A. DRUMMOND
• 金额: $ 221.35万
• 依托单位: MOUNT DESERT ISLAND BIOLOGICAL LAB
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437777
• 关键词: Adult; Aging; Animal Model; Biological; Biology of Aging; Biomedical Research; Centers of Research Excellence; Communities; Comparative Biology; Development; Development Plans; Disease; Disease model; Ensure; Environment; Faculty; Foundations; Funding; Grant; Growth; Growth and Development function; Heart; Human; Industry; Institutes; Institution; Intellectual Property; Invertebrates; Laboratories; Laboratory Research; Lead; Legal patent; Maine; Mammals; Medicine; Molecular; Myocardial Infarction; Natural regeneration; Paper; Patients; Peer Review; Peripheral Nervous System Diseases; Phase; Philanthropic Fund; Pilot Projects; Play; Process; Publications; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Resources; Role; Scientist; Services; State Government; Time; Tissue Engineering; Tissues; Translating; Vertebrates; base; career; career development; chemotherapy; comparative; drug candidate; drug discovery; engineered stem cells; functional genomics; human tissue; improved; innovation; member; novel; organ regeneration; peer; peripheral nerve damage; programs; recruit; regenerative; regenerative biology; research and development; small molecule; success; tissue regeneration; tissue repair; tool

OVERALL PROJECT SUMMARY Regeneration of damaged and lost tissues is limited in humans and other mammals. However, robust regeneration is the norm for numerous diverse invertebrates and lower vertebrates. COBRE Phase I, Comparative Biology of Tissue Repair, Regeneration and Aging, played a central role in establishing and growing the Kathryn W. Davis Center for Regenerative Biology and Medicine (Davis Center) at the MDI Biological Laboratory (MDIBL) and in dramatically improving the institution’s research environment. The Davis Center was founded on the guiding principle that studying diverse animal models would lead to a detailed and predictive understanding of the cellular and molecular mechanisms of tissue and organ regeneration, and an understanding of why these processes are poorly active in most human tissues and of why they decline with disease and aging. This in turn would lead to a rational foundation for development of regenerative medicine therapies, particularly small molecule drug candidates capable of stimulating tissue regeneration and slowing or reversing aging-induced degenerative changes in patients. COBRE Phase I supported four early-career Project Leaders and one mid-career Project Leader. All five Project Leaders graduated from Phase I with independent grant support. The average time for graduation of the four early-career Project Leaders was 2.8 years. Phase I Project Leaders also achieved multiple other successes including publication of significant peer-reviewed papers, creation of intellectual property, receipt of foundation and R21 grants and significant peer recognition. Other noteworthy successes include further development and patenting of MSI-1436, the only small molecule known to stimulate regeneration of the adult mammalian heart following a heart attack, discovery of two small molecules with potential to reverse chemotherapy-induced peripheral nerve damage, development of new disease models and research tools, and formation of a growing IDeA program/Maine state government partnership that allowed MDIBL to obtain $3M in voter-approved state bond funding to expand research infrastructure. COBRE Phase II will continue to support the growth and development of the Davis Center in order to establish a self-sustaining critical mass of investigators. Three new early-career scientists, Drs. Sam Beck, James Godwin and Jarod Rollins, have been recruited as Phase II Project Leaders. Recruitment of a fourth Davis Center faculty member is underway. Research programs of Phase II Project Leaders are highly synergistic with and bring new scientific expertise to the Davis Center. Essential services and resources will be provided to the Project Leaders and larger scientific community by continuation of the Comparative Functional Genomics Core and Comparative Animal Models Core. COBRE Phase II will greatly enhance the development of the Davis Center and MDIBL, which in turn will contribute to the continued enhancement of the biomedical research environment in Maine.

总体项目摘要 受损组织和丢失的组织的再生受到人类和其他哺乳动物的限制。但是，健壮 再生是许多潜水员无脊椎动物和下脊椎动物的规范。山一阶段， 组织修复，再生和衰老的比较生物学在建立和 种植MDI的Kathryn W. Davis再生生物学与医学中心（戴维斯中心） 生物实验室（MDIBL）以及在大大改善机构的研究环境方面。戴维斯 中心建立在指导原则的基础上，即研究潜水动物模型将导致详细的和 对组织和器官再生的细胞和分子机制的预测理解，以及 了解这些过程为什么在大多数人体组织中都很活跃，以及为什么它们会随着它们的衰落而下降 疾病和衰老。反过来，这将导致建立再生医学的理性基础 疗法，尤其是能够刺激组织再生和放缓的小分子药物候选者 或反向衰老引起的患者退化性变化。 第一阶段的COBRE支持了四名职业生涯的项目领导者和一名职业工作人员项目负责人。全部 五名项目领导者从第一阶段毕业，并获得了独立的赠款支持。平均时间 四个早期职业项目领导者的毕业是2。8年。第一阶段项目负责人也取得了成就 其他多个成功，包括发表大量同行评审论文，创建知识分子 财产，收到基金会和R21赠款以及大量同行认可。其他值得注意的成功 包括进一步开发和MSI-1436的专利，这是唯一已知刺激的小分子 心脏病发作后成年哺乳动物心脏的再生，发现两个小分子 具有逆转化疗引起的周围神经损害的潜力，新疾病的发展 模型和研究工具，以及成立的思想计划/缅因州政府伙伴关系的形成 允许MDIBL获得300万美元的投票批准的州债券资金，以扩大研究基础设施。 COBRE第二阶段将继续支持戴维斯中心的增长和发展，以便为了 建立一个自我维持的临界研究人员。三位新的早期科学家，博士。山姆·贝克， 詹姆斯·戈德温（James Godwin）和贾罗德·罗林斯（Jarod Rollins）已被招募为第二阶段项目领导人。招募第四 戴维斯中心教职员工正在进行中。第二阶段项目领导者的研究计划很高 与戴维斯中心（Davis Center）协同并将新的科学专业知识协同作用。基本的服务和资源将 通过继续进行比较，可以向项目负责人和更大的科学界提供 功能基因组学核心和比较动物模型核心。 II期鞋垫将大大增强 戴维斯中心和MDIBL的发展，这反过来将有助于继续增强 缅因州的生物医学研究环境。