Promoting Independence with Compensatory Cognitive Rehabilitation: A Pilot Clinical Trial for Early-Stage Alzheimer's Disease

通过补偿性认知康复促进独立：早期阿尔茨海默病的试点临床试验

• 批准号: 10341180
• 负责人: Alyssa Marie Lanzi
• 金额: $ 16.95万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10341180
• 关键词: Active Learning; Address; Adherence; Adult; Alzheimer' s Disease; Award; Behavior; Behavior Therapy; Behavior assessment; Behavioral Model; Bypass; Caring; Clinical; Clinical Trials; Clinical effectiveness; Cognition; Cognitive; Cognitive Therapy; Conduct Clinical Trials; Control Groups; Delaware; Dementia; Development; Development Plans; Discipline; Disease; Dissemination and Implementation; Doctor of Philosophy; Educational process of instructing; Effectiveness; Elderly; Enrollment; Evidence based intervention; Family member; Feedback; Financial compensation; Florida; Focus Groups; Funding; Future; Goals; Health Professional; Independent Living; Individual; Intervention; Intervention Trial; Knowledge; Language; Learning; Life; Literature; Maintenance; Manuals; Memory; Mentors; Mentorship; Modernization; Modification; Neuropsychology; Occupational Therapist; Occupational Therapy; Outcome; Outcome Measure; Participant; Pathologist; Patient Outcomes Assessments; Performance; Persons; Pharmacology; Phase I Clinical Trials; Population; Prevalence; Procedures; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Rehabilitation therapy; Research; Research Activity; Research Assistant; Roter; Self Efficacy; Short-Term Memory; Societies; Specific qualifier value; Speech; Speech-Language Pathology; Structure; System; Training; United States National Institutes of Health; Universities; Work; amnestic mild cognitive impairment; base; behavioral clinical trial; career development; cognitive function; cognitive rehabilitation; cognitive system; cognitive task; cognitive testing; community setting; daily functioning; design; disability; dissemination research; efficacy evaluation; experience; experimental group; implementation research; improved; innovation; learning strategy; mild cognitive impairment; multidisciplinary; person centered; pilot trial; preservation; prevent; professor; programs; psychologic; randomized trial; repaired; research study; restorative treatment; skills; success; therapy development; tool; treatment adherence; treatment comparison; treatment effect; treatment group

ABSTRACT CANDIDATE: Alyssa Lanzi, Ph.D. is an academic speech-language pathologist and Research Assistant Professor at the University of Delaware. In this K23 application, Dr. Lanzi will build on her training and research studying cognitive rehabilitation approaches that preserve independence in adults with mild cognitive impairment (MCI) and early-stage dementia from Alzheimer’s disease (AD). The objective of this award is to acquire new knowledge, skills, and experiences needed to independently conduct clinical trials of these interventions, as well as future dissemination and implementation. Her long-term goal is to establish a productive research program that develops, evaluates, and disseminates cognitive rehabilitation interventions for adults with AD and MCI. CAREER DEVELOPMENT PLAN: Dr. Lanzi proposes to: 1) learn how to design and conduct randomized controlled trials of behavioral interventions for adults with MCI and dementia from AD; 2) receive training in the multidisciplinary assessment of the cognitive, psychological, and independent living skills of this population; 3) acquire knowledge and skills related to dissemination and implementation of behavioral interventions for rehabilitation clinicians. The training plan includes rich experiential learning activities such as multidisciplinary team-based cognitive assessment activities in diverse community settings. ENVIRONMENT: Dr. Lanzi will train with a multidisciplinary team of NIH-funded mentors with expertise in clinical trials research, MCI and dementia from AD, and dissemination/implementation research. Dr. Verdolini Abbott (U Delaware), co-primary mentor, is a senior academic speech-language pathologist and has extensive expertise in clinical trials of behavioral interventions. Dr. Cohen (U Delaware), co-primary mentor, is a rehabilitation-oriented neuropsychologist with a record of multi-disciplinary cognitive assessment research. Dr. Rodakowski (U Pittsburgh), co-mentor, is an academic occupational therapist with expertise in cognitive strategy training and independent living skills for adults with MCI. Dr. Smith (U Florida), co-mentor, is a senior neuropsychologist and renowned expert in MCI, AD, and behavioral intervention approaches. RESEARCH: Most treatment approaches for MCI and dementia from AD have focused on restoring cognitive weaknesses. Unfortunately, these are suboptimal for preserving or improving independent living skills. Aim 1 of the proposed research is to conduct a pilot trial to evaluate the efficacy of the Structured External Memory Aid Treatment, a compensation-based approach for adults with MCI that promotes independent living skills by teaching the use of strategies to compensate for cognitive weaknesses (e.g., note-taking systems). Aim 2 is to evaluate the demographic, clinical, and neuropsychological predictors of treatment adherence. Aim 3 is to refine treatment procedures and materials that will be used to train future interventionists. The completion of these training and research aims are critical for Dr. Lanzi’s career development and continued success in investigating the efficacy and effectiveness of compensatory cognitive interventions that enhance the independence and quality of life of adults with AD.

抽象的 候选人：Alyssa Lanzi，博士是一名学术语言病理学家和研究助理 特拉华大学的教授。在此K23应用程序中，Lanzi博士将基于她的培训和研究 研究具有轻度认知障碍的成年人独立性的认知康复方法 （MCI）和阿尔茨海默氏病（AD）的早期痴呆症。该奖项的目的是获取新的 还需要独立进行这些干预措施的临床试验所需的知识，技能和经验 作为未来的传播和实施。她的长期目标是建立一项富有成效的研究计划 这会开发，评估和传播AD和MCI成年人的认知康复干预措施。 职业发展计划：Lanzi博士提议：1）学习如何设计和进行随机设计 AD的MCI和痴呆症的成年人的行为干预措施的对照试验； 2）接受培训 对该人群的认知，心理和独立生活技能的多学科评估； 3） 获取与传播和实施行为干预措施有关的知识和技能 康复临床医生。培训计划包括丰富的经验丰富的学习活动，例如多学科 在潜水员社区环境中基于团队的认知评估活动。环境：Lanzi博士将训练 MCI和Dementia拥有由NIH资助的导师组成的多学科团队，具有临床试验研究的专业知识 来自AD，以及传播/实施研究。联合导师的Verdolini Abbott博士（U特拉华州） 一位高级学术语言病理学家，在行为临床试验方面拥有广泛的专业知识 干预措施。共同主要导师Cohen博士（U Delaware）是一名面向康复的神经心理学家 多学科认知评估研究的记录。 Rodakowski博士（U Pittsburgh），同事，是一个 具有认知策略培训专家的学术职业治疗师和独立生活技能 成人MCI。史密斯博士（U佛罗里达州），同事，是MCI的高级神经心理学家和著名专家 广告和行为干预方法。研究：MCI和痴呆症的大多数治疗方法 来自AD的重点是恢复认知弱点。不幸的是，这些是为了保存或 提高独立的生活技能。拟议研究的目标1是进行试点试验以评估 结构化外部记忆援助治疗的功效，这是MCI成年人的基于薪酬的方法 通过教导使用策略来弥补认知弱点，从而促进独立的生活技能 （例如，笔记系统）。目标2是评估人口，临床和神经心理学预测指标 治疗依从性。 AIM 3是完善用于训练未来的治疗程序和材料 干预主义者。这些培训和研究目标的完成对Lanzi博士的职业至关重要 发展和持续成功调查补偿认知的有效性和有效性 增强AD成人生活的独立性和生活质量的干预措施。