Quantitative characterization of vitreous degeneration in myopia

近视玻璃体变性的定量表征

• 批准号: 8823987
• 负责人: Jeffrey Ketterling
• 金额: $ 23.41万
• 依托单位: RIVERSIDE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8823987
• 关键词: Acoustics; Adhesions; Agar; Age related macular degeneration; Aging; Blindness; Cataract; Clinical; Collagen; Custom; Data; Data Collection; Degenerative Myopia; Development; Devices; Diabetes Mellitus; Diabetic Retinopathy; Diagnostic Procedure; Disease; Disease Progression; Event; Eye; Family suidae; Frequencies; Gel; Goals; Hand; Image; Imaging Device; Imaging technology; Immersion Investigative Technique; In Situ; Intervention; Iris; Lateral; Length; Liquid substance; Macular Hole; Measures; Mechanics; Medical; Methods; Mono-S; Myopia; Optical Coherence Tomography; Outcome; Pathology; Patients; Positioning Attribute; Posterior Vitreous Detachments; Posterior eyeball segment structure; Process; Protocols documentation; Pupil; Relative (related person); Resolution; Retina; Retinal; Retinal Detachment; Retinal Diseases; Retinoschisis; Scanning; Sclera; Signal Transduction; Solid; Staging; Structure; Supine Position; Syndrome; System; Techniques; Technology; Testing; Therapeutic Intervention; Time; Tissues; Traction; Ultrasonography; Vitreous Hemorrhage; Vitreous body structure; age related; base; crosslink; diabetic; disorder of macula of retina; human subject; imaging modality; imaging system; in vivo; infancy; innovation; macula; macular edema; normal aging; novel; prototype; public health relevance; quantitative ultrasound; signal processing; vitreous floater; vitreous state

DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a quantitative, ultrasound-based assessment of the vitreous as it relates to vitreo-retinal diseases, such as myopia and diabetic retinopathy, at an early stage before severe outcomes (e.g., blindness) occur. Normal age-related changes (e.g., collagen cross-linking and aggregation, liquefaction, cellular debris, etc.) create inhomogeneities, such as floaters, to appear throughout the vitreous in a non-uniform distribution; these inhomogeneities can serve as weak acoustic scatterers. Concurrent changes at the vitreo-retinal interface weaken the adhesion of the posterior vitreous cortex to the internal limiting lamina of the retina, resulting in posterior viteous detachment. For patients with myopia, these normal processes do not typically occur in tandem because liquefaction is accelerated and the vitreous destabilizes before the vitreous adhesion to the retina is weakened. No diagnostic method is now available to characterize the changes taking place throughout the vitreous volume at an early stage before irreversible pathologies have developed or to determine how these changes relate to progression of diseases. Thus, a clinical need exists to detect within the vitreous the macromolecular changes and structural precursors related to vitreo-retinal disease. We will assemble a novel, high-resolution, annular-array ultrasound system capable of acquiring image data of the entire vitreous and then use quantitative ultrasound methods to characterize vitreous inhomogeneities based on parameters derived from raw ultrasound backscatter signals. The system will utilize state-of-the-art, 20-MHz, annular-array technology to achieve an unprecedented improvement in depth-of-field, resolution and sensitivity relative to current clinical ultrasound technology. The proposed technology will overcome limitations of optical coherence tomography, such as its restricted lateral view through the pupil (due to opaque intervening structures such as the iris, sclera, and possibly cataracts) and its inability to image optically transparent tissue. The early stages of th project will emphasize assembling a hand-held clinical prototype annular-array system and developing signal-processing methods. Later stages will focus on human-subject imaging and quantification of vitreous inhomogeneities occurring during normal aging and myopia.

描述（由申请人提供）：该项目的最终目标是开发一种基于超声的定量玻璃体评估，因为它与玻璃体视网膜疾病相关， 例如近视和糖尿病视网膜病变，发生在严重后果（例如失明）之前的早期阶段。正常的与年龄相关的变化（例如胶原蛋白交联和聚集、液化、细胞碎片等）会产生不均匀性，例如飞蚊症，从而出现在整个过程中 玻璃体分布不均匀；这些不均匀性可以充当弱声散射体。玻璃体-视网膜界面的同时变化削弱了后玻璃体皮质与视网膜内界层的粘附，导致后玻璃体脱离。对于近视患者，这些正常过程通常不会同时发生，因为在玻璃体与视网膜的粘附减弱之前，液化会加速并且玻璃体不稳定。现在还没有诊断方法可以在不可逆病理发生之前的早期阶段表征整个玻璃体体积发生的变化，或者确定这些变化与疾病进展的关系。因此，临床需要检测玻璃体内与玻璃体视网膜疾病相关的大分子变化和结构前体。我们将组装一种新颖的高分辨率环形阵列超声系统，能够采集整个玻璃体的图像数据，然后根据原始超声反向散射信号导出的参数，使用定量超声方法来表征玻璃体不均匀性。该系统将利用最先进的 20 MHz 环形阵列技术，相对于当前的临床超声技术，在景深、分辨率和灵敏度方面实现前所未有的改进。所提出的技术将克服光学相干断层扫描的局限性，例如其通过瞳孔的横向视野受限（由于虹膜、巩膜和可能的白内障等不透明的介入结构）以及无法对光学透明组织进行成像。该项目的早期阶段将侧重于组装手持式临床原型环形阵列系统并开发信号处理方法。后期阶段将重点关注正常衰老和近视期间发生的玻璃体不均匀性的人体成像和量化。