Core 1: PRACTICE Shared Resource Core

核心1：实践共享资源核心

• 批准号: 10328040
• 负责人: Debra L. Friedman
• 金额: $ 33.13万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328040
• 关键词: Address; Area; Behavioral Sciences; Biometry; Breast; Breast Cancer Risk Factor; Cancer Center; Cancer Control; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Community Developments; Conduct Clinical Trials; Continuity of Patient Care; Coupled; Data; Disease; Early Diagnosis; Educational Materials; Enrollment; Epidemiology; Etiology; Evaluation; Exclusion Criteria; Experimental Designs; Future; General Hospitals; Goals; Health; Healthcare; Incidence; Information Dissemination; Infrastructure; Institution; Intervention; Intervention Trial; Investigator-Initiated Research; Learning; Link; Logic; Longitudinal cohort; Lung; Malignant Neoplasms; Mentorship; Methods; Minority Access; Mission; Modeling; Observational Study; Oncology; Outcome; Palliative Care; Pathology; Patient Recruitments; Patient-Focused Outcomes; Patients; Population Research; Population Sciences; Prevention; Public Hospitals; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; Risk Assessment; Risk Factors; Science; Screening for cancer; Self Management; Students; Supportive care; Tennessee; Therapeutic Clinical Trial; Time; Training; Trust; Underserved Population; Universities; Woman; Work; anticancer research; base; behavioral health; cancer care; cancer diagnosis; cancer health disparity; cancer subtypes; cancer therapy; care delivery; clinical infrastructure; cohort; community engaged research; community engagement; comorbidity; control trial; design; education research; ethnic minority population; improved; inclusion criteria; lung cancer screening; malignant breast neoplasm; medical schools; metropolitan; mortality; neoplasm registry; outreach; patient population; population based; pre-doctoral; prospective; racial minority; recruit; research study; safety net; success; survivorship; tobacco control; trial design

PROJECT SUMMARY: PRACTICE SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, we must augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. We propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum, illustrated in three thematic domains focused on decreasing cancer health disparities: prevention and early detection; interventional trials and observational studies during and following treatment; implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Core will address the following aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.

项目摘要：实践共享资源核心 拟议的人口研究和癌症公平（实践）共享资源核心的临床试验 将建立在现有的临床试验核心（CTC）的基础设施基础上 Meharry/Vanderbilt-Ingram癌症中心/田纳西州癌症伙伴关系（MVTCP）以来 成立。尽管CTC一直在将临床试验带到纳什维尔的患者基础上 Meharry医学院（MMC）的综合医院（NGH），更完全解决癌症健康 差异，我们必须通过在预防，早期检测，治疗方面的研究中加强这些努力 纳什维尔大都会统计区（MSA）的生存和姑息治疗，我们 合伙。我们建议建立实践共享资源核心，以进一步受益于NGH 患者基础，促进研究人员发起的研究并将伙伴关系扩展到服务不足 在纳什维尔MSA中。 MVTCP在人群科学研究中具有很大的力量，这将增强 临床研究中的现有力量。例子包括田纳西州立大学MMC领导的研究 和范德比尔特 - 伊吉拉姆癌症中心（VICC）的研究人员与全州癌症注册机构一起招募 对于乳腺癌的病因研究，肺癌筛查试验早期检测，一项烟草控制试验 服务欠佳的，加强了参与者招募癌症研究和收集生物测量的人 与癌症外展核心和转化病理学的合作共享资源核心。有一个 在临床试验办公室（CTO）之间进行相互作用进行治疗临床试验的丰富历史 VICC和NGH的CTO。实践共享资源核心的总体使命是增强 应对治疗性临床试验的应计，同时扩大了少数族裔和服务不足的患者的访问 跨癌症护理连续性的研究。实践核心与医学博士露西·斯帕卢托（Lucy Spalluto）广泛合作 在她提出的项目的起源中，研究了乳腺癌风险评估的实施 服务不足的妇女。我们将协助实施这项研究和结果传播。我们的核心 还将支持整个癌症护理连续体的其他基于临床和人群的科学研究， 在三个主题领域中进行了说明，重点是减少癌症健康差异：预防和早期 检测；治疗期间和之后的介入试验和观察研究；实施 改善癌症护理提供的医疗干预措施。实践核心将解决以下目标： 1）扩大与患者基础有关的治疗临床试验和癌症控制研究的组合 NGH在Meharry和Nashville MSA； 2）在梅哈里（Meharry）的NGH开发癌症队列，以作为一种资源 在癌症护理连续体中进行未来的研究； 3）为临床学员提供培训和指导 在进行临床试验以及在研究中招募和保留率低的人群中。