Core 1: PRACTICE Shared Resource Core

核心1：实践共享资源核心

• 批准号: 10328040
• 负责人: Debra L. Friedman
• 金额: $ 33.13万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10328040
• 关键词: Address; Area; Behavioral Sciences; Biometry; Breast; Breast Cancer Risk Factor; Cancer Center; Cancer Control; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communities; Community Developments; Conduct Clinical Trials; Continuity of Patient Care; Coupled; Data; Disease; Early Diagnosis; Educational Materials; Enrollment; Epidemiology; Etiology; Evaluation; Exclusion Criteria; Experimental Designs; Future; General Hospitals; Goals; Health; Healthcare; Incidence; Information Dissemination; Infrastructure; Institution; Intervention; Intervention Trial; Investigator-Initiated Research; Learning; Link; Logic; Longitudinal cohort; Lung; Malignant Neoplasms; Mentorship; Methods; Minority Access; Mission; Modeling; Observational Study; Oncology; Outcome; Palliative Care; Pathology; Patient Recruitments; Patient-Focused Outcomes; Patients; Population Research; Population Sciences; Prevention; Public Hospitals; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Risk; Risk Assessment; Risk Factors; Science; Screening for cancer; Self Management; Students; Supportive care; Tennessee; Therapeutic Clinical Trial; Time; Training; Trust; Underserved Population; Universities; Woman; Work; anticancer research; base; behavioral health; cancer care; cancer diagnosis; cancer health disparity; cancer subtypes; cancer therapy; care delivery; clinical infrastructure; cohort; community engaged research; community engagement; comorbidity; control trial; design; education research; ethnic minority population; improved; inclusion criteria; lung cancer screening; malignant breast neoplasm; medical schools; metropolitan; mortality; neoplasm registry; outreach; patient population; population based; pre-doctoral; prospective; racial minority; recruit; research study; safety net; success; survivorship; tobacco control; trial design

PROJECT SUMMARY: PRACTICE SHARED RESOURCE CORE The proposed Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core will build upon the infrastructure of the existing Clinical Trials Core (CTC) that has provided support to the Meharry/Vanderbilt-Ingram Cancer Center/Tennessee State Cancer Partnership (MVTCP) since its inception. While the CTC has been instrumental in bringing clinical trials to the patient base at Nashville General Hospital (NGH) at Meharry Medical College (MMC), to more completely address cancer health disparities, we must augment these efforts with studies in prevention, early detection, treatment, survivorship and palliative care in the Nashville Metropolitan Statistical Area (MSA), served by our Partnership. We propose to establish the PRACTICE Shared Resource Core to further benefit the NGH patient base, promote investigator-initiated research and extend the Partnership's reach to the underserved in the Nashville MSA. The MVTCP has great strength in population sciences research that will enhance the existing strength in clinical research. Examples include studies led by MMC, Tennessee State University and Vanderbilt-Ingram Cancer Center (VICC) investigators working with statewide cancer registries to recruit for etiologic studies of breast cancer, lung cancer screening trials for early detection, a tobacco control trial in the underserved, enhancing participant recruitment to cancer research and collection of biospecimens in collaboration with the Cancer Outreach Core and Translational Pathology Shared Resource Core. There is a rich history of conducting therapeutic clinical trials with interactions between the Clinical Trials Office (CTO) at VICC and the CTO at NGH. The overarching mission of the PRACTICE Shared Resource Core is to enhance accrual to therapeutic clinical trials while expanding access for minority and underserved patients to research studies across the cancer care continuum. The PRACTICE Core worked extensively with Lucy Spalluto, MD in the genesis of her proposed project examining the implementation of breast cancer risk assessment in underserved women. We will assist with implementation of this study and dissemination of the results. Our Core will also support other clinical and population-based science research across the cancer care continuum, illustrated in three thematic domains focused on decreasing cancer health disparities: prevention and early detection; interventional trials and observational studies during and following treatment; implementation of healthcare interventions to improve cancer care delivery. The PRACTICE Core will address the following aims: 1) expand the portfolio of therapeutic clinical trials and cancer control studies relevant to the patient base of NGH at Meharry and the Nashville MSA; 2) develop a cancer cohort at NGH at Meharry to serve as a resource for future studies across the cancer care continuum; and 3) provide training and mentorship for clinical trainees in the conduct of clinical trials and in the recruitment and retention of underserved populations in research.

项目摘要：实践共享资源核心 拟议的癌症人群研究和临床试验公平性 (PRACTICE) 共享资源核心 将建立在现有临床试验核心（CTC）的基础设施之上，该基础设施为 梅哈里/范德比尔特-英格拉姆癌症中心/田纳西州癌症合作伙伴关系 (MVTCP) 自成立以来 成立。 CTC 在将临床试验带入纳什维尔的患者群体方面发挥了重要作用 梅哈里医学院 (MMC) 综合医院 (NGH)，更全面地解决癌症健康问题 差距，我们必须通过预防、早期发现、治疗、 纳什维尔大都会统计区 (MSA) 的生存和姑息治疗，由我们的服务 合伙。我们建议建立PRACTICE共享资源核心，以进一步使NGH受益 患者基础，促进研究者发起的研究并将合作伙伴关系的范围扩大到服务不足的地区 在纳什维尔 MSA。 MVTCP 在人口科学研究方面拥有强大的实力，这将增强 现有临床研究实力。例子包括由田纳西州立大学 MMC 领导的研究 和范德比尔特-英格拉姆癌症中心 (VICC) 研究人员与全州癌症登记处合作招募 用于乳腺癌的病因学研究、早期发现的肺癌筛查试验、烟草控制试验 服务不足的地区，加强癌症研究参与者的招募和生物样本的收集 与癌症外展核心和转化病理学共享资源核心合作。有一个 通过临床试验办公室 (CTO) 之间的互动进行治疗性临床试验的丰富历史 VICC 和 NGH 的首席技术官。 PRACTICE 共享资源核心的首要任务是增强 增加治疗性临床试验的机会，同时扩大少数族裔和服务不足的患者参与研究的机会 整个癌症护理连续体的研究。实践核心与医学博士 Lucy Spalluto 进行了广泛合作 在她提议的项目的起源中，该项目审查了乳腺癌风险评估的实施情况 服务不足的女性。我们将协助实施这项研究并传播结果。我们的核心 还将支持整个癌症护理连续体中的其他临床和基于人群的科学研究， 阐述了三个主题领域，重点关注减少癌症健康差异：预防和早期治疗 检测；治疗期间和治疗后的介入试验和观察性研究；实施 改善癌症护理服务的医疗保健干预措施。实践核心将实现以下目标： 1）扩大与患者基础相关的治疗性临床试验和癌症控制研究的组合 梅哈里 (Meharry) 的 NGH 和纳什维尔 MSA； 2) 在 Meharry 的 NGH 建立一个癌症队列作为资源 用于整个癌症护理连续体的未来研究； 3）为临床实习生提供培训和指导 进行临床试验以及招募和保留服务不足的人群进行研究。