Biostatistics Core

生物统计学核心

基本信息

批准号：
10327940
负责人：
Tao Lu
金额：
$ 7.12万
依托单位：
MEHARRY MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10327940
关键词：
Address Bioinformatics Bioinformatics Shared Resource Biological Biometry Biostatistics Core Biostatistics Shared Resource Cancer Center Clinical Clinical Trials Collaborations Computer software Consultations Data Analyses Development Educational workshop Ensure Experimental Designs Funding Human Resources Individual Information Storage Laboratory Study Maintenance Malignant Neoplasms Manuscripts Methodology Methods Participant Pilot Projects Publications Quality Control Questionnaire Designs Reporting Research Research Design Research Personnel Retrieval Role Sample Size Services Statistical Data Interpretation Tennessee The Vanderbilt-Ingram Cancer Center at the Vanderbilt University Training Universities Work Writing cancer health disparity data cleaning data quality data visualization database design design experimental study investigator training medical schools member multidimensional data posters power analysis relational database symposium

项目摘要

PROJECT SUMMARY: BIOSTASTICS AND BIOINFORMATICS SHARED RESOURCE CORE In this application, we propose to intensify the role of our existing Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) Bioinformatics and Biostatistics Shared Resource Core (BBSRC). The BBSRC will support two full projects and one pilot project; detailed and specific biostatistical and bioinformatic analysis plans are provided for each specific aim/sub-aim within each project. Sample size for each primary experiment is computed to provide high power to detect clinically or biologically relevant effects. For projects with high-dimensional data analyses, the methods described in the Research Strategy will be applied to assess data quality and then perform statistical analysis only after preprocessing to address quality issues. BBSRC support is required for all MVTCP studies, with biostatisticians and bioinformaticians from this core assigned to each project. BBSRC personnel have worked and will continue to work closely with project leaders to ensure the Biostatistics and Bioinformatics Shared Resource Core provides state-of-the-art statistical/bioinformatic support to the MVTCP.

项目摘要：生物统计学和生物信息学共享资源核心在此申请中，我们建议加强现有梅哈里医学院/范德比尔特-英格拉姆学院的作用癌症中心/田纳西州立大学癌症合作伙伴 (MVTCP) 生物信息学和生物统计学共享资源核心（BBSRC）。 BBSRC 将支持两个完整项目和一个试点项目；详细和为每个具体目标/子目标提供具体的生物统计和生物信息学分析计划项目。计算每个主要实验的样本量，以提供高功效来检测临床或生物学相关的影响。对于具有高维数据分析的项目，中描述的方法研究策略将应用于评估数据质量，然后仅在完成后进行统计分析预处理以解决质量问题。所有 MVTCP 研究都需要 BBSRC 的支持，以及生物统计学家的支持该核心的生物信息学家被分配到每个项目。 BBSRC 人员已经并将继续工作与项目负责人密切合作，确保生物统计学和生物信息学共享资源核心为 MVTCP 提供最先进的统计/生物信息支持。