DCEG- Genotyping for epidemiology studies

DCEG-流行病学研究的基因分型

基本信息

批准号：
10329733
负责人：
LEONARD FREEDMAN
金额：
$ 505.23万
依托单位：
LEIDOS BIOMEDICAL RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-31 至 2021-08-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10329733
关键词：
Affect American Cancer Society Area Basic Science Beta Carotene Biological Assay Cancer Burden Cervical Cancer Screening Colon Custom DNA Data Data Analyses Data Storage and Retrieval Development Disease Disease Outcome Division of Cancer Epidemiology and Genetics Employment Environmental Risk Factor Epidemiologist Experimental Designs Family Generations Genes Genetic Genetic Markers Genetic Variation Genome Scan Genomics Genotype Heritability Human Genome Human Papillomavirus Image Immunohistochemistry Individual Informatics Information Management Intramural Research Program Laboratories Laboratory Research Lung Malignant Neoplasms Meta-Analysis Molecular Epidemiology Mutation Normal tissue morphology Nucleic Acids Outcome Ovarian Phenotype Population Population Group Predisposition Prostate Publishing Research Research Support Resources Sampling Scanning Scientist Specimen Statistical Methods Support Groups Surveys Techniques Technology Tissues Work alpha Tocopherol anticancer research bioinformatics pipeline cancer genomics cancer prevention case control clinically relevant cohort cost data access database of Genotypes and Phenotypes design digital digital pathology epidemiology study exome exome sequencing follow-up genetic epidemiology genetic variant genome sequencing genome wide association study genome-wide human genomics interest molecular pathology novel rare variant response screening tissue processing tumor

项目摘要

The Cancer Genomics Research (CGR) Laboratory was established to investigate the contribution of genetic variation to cancer susceptibility and outcomes. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG’s intramural research program, the CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. New work has begun in somatic research with the use of tumor/normal tissue nucleic acids for cross-platform comparisons in subjects of interest. A support group for molecular and digital pathology research within CGR has been added to support these efforts. CGR supports DCEG in all stages of cancer research from planning to publishing, including experimental design and project management, sample handling, genotyping and sequencing assay design and execution, tissue research support, development and implementation of bioinformatic pipelines, and downstream research and analytical support. These factors make CGR a unique collaborative center for NCI-driven scientific endeavors.

建立了癌症基因组学研究（CGR）实验室，以研究遗传变异对癌症易感性和结果的贡献。与流行病学家，生物统计学家和基础研究科学家合作，CGR提供了进行全基因组发现研究和有针对性的区域方法的能力，以确定可遗传各种形式的癌症的可遗传决定。通过使用肿瘤/正常组织核酸进行跨平台比较，在体细胞研究中开始了新的工作。添加了CGR中分子和数字病理研究的支持小组，以支持这些努力。 CGR在癌症研究的各个阶段都支持DCEG，包括实验设计和项目管理，样本处理，基因分型和测序测定设计和执行，组织研究支持，生物信息学管道的开发和实施，以及下游研究和分析支持。这些因素使CGR成为NCI驱动的科学努力的独特协作中心。