Development of a Smart PFAS-Collector for High-Throughput PFAS Detection

开发用于高通量 PFAS 检测的智能 PFAS 收集器

• 批准号: 10327033
• 负责人: Alexis Wells Carpenter
• 金额: $ 16.81万
• 依托单位: AXNANO, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10327033
• 关键词: Acids; Address; Anions; Assessment tool; Awareness; Binding; Budgets; Charge; Chemical Structure; Chemicals; Communities; Contracts; Coupled; Data; Data Analytics; Detection; Development; Devices; Electron Microscopy; Environment; Environmental Engineering technology; Equipment; Exercise; Exhibits; Exposure to; Fingerprint; Fire - disasters; Fluorescence; Formulation; Goals; Hazardous Substances; Health; Health Hazards; Human; Human Resources; Image; Imaging Device; Industry; Laboratories; Maps; Mass Spectrum Analysis; Measurable; Measures; Methods; Monitor; Municipalities; Nanotechnology; Optical Methods; Optics; Outcome; Phase; Plant Resins; Preparation; Privatization; Program Development; Property; Research; Resolution; Risk; Sampling; Screening procedure; Ships; Signal Transduction; Site; Small Business Innovation Research Grant; Societies; Solid; Solvents; Source; Specificity; Spectrum Analysis; Structure-Activity Relationship; Superfund; Surface; Technology; Testing; Time; Training; Uncertainty; Waste Products; Water; Water Supply; Work; aqueous; base; consumer product; contaminated drinking water; cost; design; detection limit; detection method; detector; drinking water; exposed human population; exposure route; feasibility testing; fighting; fluorescence imaging; functional group; ground water; improved; innovation; instrumentation; landfill; light scattering; manufacturability; materials science; multidisciplinary; nanoparticle; novel; perfluorooctanoic acid; physical property; portability; programs; prototype; screening; sensor; tool; water testing

Project Summary/Abstract 1 Rising awareness of the ubiquity of per- and polyfluoroalkyl substances (PFAS) coupled with 2 growing evidence of human health hazards has led to increased PFAS testing of water sources 3 that feed drinking-water supplies. Early estimations of the PFAS treatment market are at $3.1Bn, 4 with testing representing a key revenue driver. While highly accurate, current high resolution mass 5 spectroscopy (HRMS) PFAS detection methods have high per sample costs and long turnaround 6 times. The specialized equipment is expensive and requires skilled personnel and laborious 7 sample preparation. As a result, budget-strapped stakeholders may limit the comprehensive 8 testing needed for site assessment. Long turnaround times can mean continued community 9 exposure and uncertainty of clean-up progress. AxNano is developing a low-cost, high- 10 throughput, portable PFAS-detection method. We aim to initially develop this as a screening tool 11 for environmental engineers to provide real-time data of elevated PFAS levels to inform exposures 12 and further testing needs. Long-term goals are to achieve specificity and detection limits 13 necessary for receiving EPA approval. This technology meets the specific Superfund Research 14 Program need of “nanotechnology-based sensors” to “characterize [and] monitor hazardous 15 substances at contaminated sites”. 16 The specific objectives of this Phase I SBIR program are the development of and bench-scale 17 testing of AxNano’s PFAS-targeting “smart” collector, which is a key component of our high 18 throughput PFAS detector. The long-term objectives of this multidisciplinary technology 19 development program will integrate material science, advanced spectroscopy, and data analytics. 20 The key innovation in this work is unique PFAS-targeting nanoparticles that will produce a 21 fluorescence signal upon binding PFAS. Our initial goal is ppb level detection, and ultimately ppt 22 to meet regulatory requirements. Specific tasks of this Phase I include lab-scale manufacturing of 23 a suite of surface-modified fluorescent nanoparticles and testing for PFAS-targeting and - 24 detecting abilities. Promising candidates will be down-selected according to specific criteria and 25 integrated into a pre-prototype “smart” collector, which will then be tested at bench-scale. Phase 26 I will test proof-of-concept against standard solutions of perfluorooctanoic acid (PFOA), 27 perfluorooctanesulfonic acid (PFOS), and an Aqueous Fire Fighting Foam (AFFF) Ansulite. 28 Additional tasks involve preparing for prototyping and broader PFAS compound testing in realistic 29 environments in Phase II.

项目摘要/摘要 1对普遍存在的普遍性和多氟烷基物质（PFA）的意识上升 2越来越多的人类健康危害的证据导致了PFAS的水源测试增加 3喂食饮用水供应。 PFA治疗市场的早期估计为31亿美元 4测试代表关键收入驱动器。虽然高度准确，但当前高分辨率质量 5光谱法（HRMS）PFAS检测方法的每个样本成本较高，周转较长 6次。专业设备很昂贵，需要熟练的人和费力 7样品准备。结果，预算短缺的利益相关者可能会限制全面的 8现场评估所需的测试。漫长的周转时间可能意味着持续的社区 9清理进度的暴露和不确定性。 Axnano正在发展低成本，高 - 10吞吐量，便携式PFAS检测方法。我们的目标是最初将其作为筛选工具开发 11让环境工程师提供升高PFAS水平的实时数据以告知暴露 12并进一步测试需求。长期目标是达到特异性和检测限制 13获得EPA批准所必需的。这项技术符合特定的超级基金研究 14“基于纳米技术的传感器”的程序需要“表征[和]监测危险 在受污染的地点有15种物质”。 16该阶段I SBIR计划的具体目标是开发和台式规模 17测试Axnano的PFA靶向“ Smart”收藏家，这是我们高的关键组成部分 18吞吐量PFA检测器。这项多学科技术的长期目标 19开发计划将整合材料科学，高级光谱和数据分析。 20这项工作中的关键创新是独特的PFA靶向纳米颗粒，将产生一个 结合PFA时21荧光信号。我们的最初目标是PPB级检测，最终是PPT 22满足监管要求。该阶段的特定任务包括实验室规模的制造 23一套表面修饰的荧光纳米颗粒和靶向PFA的测试和 - 24检测能力。有前途的候选人将根据特定标准降低选择 25整合到了前型“智能”收集器中，然后将在台式尺度进行测试。阶段 26我将针对全氟辛酸（PFOA）的标准解决方案测试概念验证， 27全氟辛磺酸（PFO）和战斗泡沫（AFFF）的水。 28其他任务涉及准备原型制作和更广泛的PFA化合物测试 第二阶段的29个环境。