Animal Behavior & Neurophysiology

动物行为

基本信息

批准号：
10445286
负责人：
Deborah A Cory-Slechta
金额：
$ 18.45万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10445286
关键词：
Affect Animal Behavior Animal Model Behavior Behavioral Behavioral Assay Biological Assay Cells Cognition Complex Analysis Computer software Consultations Data Data Collection Development Ensure Equipment Faculty Generations Genes Goals Individual Infrastructure Intellectual and Developmental Disabilities Research Centers Intervention Investigation Laboratories Laboratory Research Leadership Link Measures Methodology Methods Neurons Neurosciences Research Phase Play Population Protocols documentation Reproducibility Research Research Personnel Research Project Grants Resources Rodent Model Sensory Social Behavior Techniques Training Universities Work analytical method behavioral study design experimental study insight large datasets medical schools member morris water maze neuronal patterning neurophysiology new technology relating to nervous system social theories

项目摘要

Project Summary: The URMC IDDRC Animal Behavior and Neurophysiology (ABN) Core will provide IDDRC members with access to behavioral and neurophysiological assays in rodent models that harness the expertise of the Core leadership and allow for investigation of the neural underpinnings of IDDs. The Core’s Components in animal behavior and neurophysiology are already central to work being conducted by IDDRC investigators, providing access to equipment, techniques, and analyses that are central to current neuroscience research. By providing access to well established assays that are essential to IDD research, the animal behavior component of the Core allows investigators to relate changes at the gene, cell, and circuit level in the animal models to behaviors that may provide mechanistic insight into IDDs. Similarly, by providing access to single neuron, multiunit, and population activity measures, the neurophysiology component of the core allows investigators to further establish bridges that link changes in patterns of neuronal activity to behavioral changes that may underlie a number of IDDs. Both components of the Core have continued to advance and validate new technologies; both are also critical to the Research Project. The ABN Core will be supported by dedicated administrative and technical faculty and staff to provide critical expertise in the design, implementation, and analysis of both behavioral and neurophysiological assays critical to IDD research. To achieve this, three Aims are proposed. Aim 1 is to provide vital access to resources (both equipment and expertise) for carrying out behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 2 will provide technical and methodological guidance and support to generate data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Aim 3 will provide analysis and statistical guidance and support to interpret data in both behavioral and neurophysiological assays critical to IDDRC investigator research. Collectively, the ABN Core of the URMC IDDRC will allow investigators to perform behavioral and neurophysiological assays in animal models to gain insight into the neural underpinnings of IDDs. Through its interactions with other IDDRC Cores, it will advance the long-term goal of identifying interventions and treatments at the cellular, neurophysiological, and behavioral levels.

项目摘要：URMC IDDRC动物行为和神经生理学（ABN）核心将提供IDDRC 可以在啮齿动物模型中获得行为和神经生理测定的成员，以利用专业知识核心领导层，并允许投资IDD的神经基础。核心的动物行为和神经生理学的组成部分已经是IDDRC进行的工作的核心调查人员提供对当前核心的设备，技术和分析的访问神经科学研究。通过提供对IDD研究至关重要的良好测定的访问核心的动物行为成分允许研究人员在基因，细胞和电路上关联变化动物模型中的水平与可能为IDD提供机械洞察力的行为。同样，通过提供访问单个神经元，多活性和人群活动度量，该方法是神经生理学的成分核心使研究人员能够进一步建立桥梁，将神经元活动模式的变化联系起来行为变化可能是许多IDD的基础。核心的两个组成部分都继续进步和验证新技术；两者也对研究项目至关重要。 ABN核心将是在专门的行政和技术教职员工的支持下，以提供设计的重要专业知识，对IDD研究至关重要的行为和神经生理测定法的实施和分析。到目的1是提供对资源（设备和专业知识）进行行为和神经生理学测定至关重要的IDDRC研究者研究。 AIM 2将提供技术和方法论指导和支持，以生成行为和行为的数据神经生理学测定对IDDRC研究者研究至关重要。 AIM 3将提供分析和统计指导和支持以解释行为和神经生理测定的数据对IDDRC至关重要研究者研究。总体而言，URMC IDDRC的ABN核心将允许调查人员执行动物模型中的行为和神经生理测定，以深入了解 IDD。通过与其他IDDRC核心的互动，它将促进确定的长期目标细胞，神经生理和行为水平的干预和治疗。