Improved Delivery System for Drug-Coated Balloon Therapy

改进的药物涂层球囊治疗输送系统

基本信息

批准号：
10324442
负责人：
Nick Rydberg
金额：
$ 29.93万
依托单位：
MINNESOTA HEALTHSOLUTIONS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10324442
关键词：
Adverse event Affect Amputation Arterial Occlusive Diseases Arteries Atherosclerosis Balloon Angioplasty Balloon Dilatation Biomechanics Caliber Cardiovascular system Catheters Cause of Death Cessation of life Characteristics Cholesterol Chronic Collaborations Computer software Coronary Arteriosclerosis Cost Sharing Data Deposition Development Devices Diffuse Diffusion Disease Dissection Doctor of Philosophy Drug Delivery Systems Drug Kinetics Drug Transport Electrical Engineering Engineering Event Fiber Friction Funding Gangrene Hand Hospitals Incidence Intervention Investments Lead Lesion Limb structure Lower Extremity Mechanical Stress Mechanics Medical Meta-Analysis Microscopic Minnesota Modeling North America Oryctolagus cuniculus Paclitaxel Pain Penetration Periodicity Peripheral Peripheral arterial disease Persons Pharmaceutical Preparations Phase Physiologic pulse Privatization Property Pump R44 grant Recording of previous events Research Resources Scientist Solubility Specific qualifier value Stress Structure Surface Symptoms System Time Tissues Ulcer United States United States National Institutes of Health Vascular Diseases Vascular blood supply Woman antiproliferative agents antiproliferative drugs artery occlusion common treatment design design and construction drug efficacy experience hemodynamics improved improved outcome in vivo innovation instrumentation lipophilicity loss of function medical schools novel novel therapeutics product development prototype reduce symptoms repaired research and development response restenosis shear stress uptake

项目摘要

Project Summary/Abstract We propose to develop a novel angioplasty balloon inflation system to improve the efficacy of drug-coated balloon angioplasty. Atherosclerosis, characterized by the deposition of plaques of fatty material on the inner walls of arteries, can lead to the development of peripheral arterial disease (PAD) due to obstructive narrowing of arteries that supply blood to the extremities. PAD frequently causes a wide variety of ischemic symptoms including pain, non-healing arterial insufficiency ulcers, lower limb tissue loss and gangrene. Percutaneous drug-coated balloon angioplasty of PAD blockages has been observed to reduce symptoms, salvage affected limbs and prolong survival.

项目摘要/摘要我们建议开发一种新型的血管成形术气球通货膨胀系统，以提高药物涂覆的功效气球血管成形术。动脉粥样硬化，其特征是内部脂肪材料的斑块沉积动脉壁，可能导致由于阻塞性狭窄而导致周围动脉疾病（PAD）的发展向四肢供血的动脉。垫经常引起多种缺血症状包括疼痛，非愈合动脉功能不全溃疡，下肢组织损失和坏疽。经皮已经观察到药物涂覆的垫阻塞的气球血管成形术可减轻症状，抢救影响四肢和延长生存。