BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM

共同促进大脑健康：基于小组的直播数字节目

• 批准号: 10324919
• 负责人: Deborah E. Barnes
• 金额: $ 150.5万
• 依托单位: TOGETHER SENIOR HEALTH, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10324919
• 关键词: Address; Age; Aging; Alzheimer' s disease related dementia; American; Awareness; Behavior Therapy; Blood Pressure; Brain; Businesses; Caregivers; Clinical; Cognitive; Control Groups; Dementia; Development; Diabetes Mellitus; Elderly; Emotional; Evidence based program; Exercise; Goals; Health; Home; Human; Hypertension; Impaired cognition; Informal Social Control; Intervention; Life Style; Maintenance; Mediating; Mental Depression; Mission; Movement; Outcome; Participant; Personal Satisfaction; Persons; Pharmaceutical Preparations; Phase; Physical Function; Positioning Attribute; Process; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Research Proposals; Rest; Risk; Risk Factors; Risk Reduction; Small Business Innovation Research Grant; Social isolation; Techniques; Testing; Training; Vulnerable Populations; Woman; Work; base; brain health; cognitive benefits; cognitive function; comparison group; daily functioning; dementia risk; design; diabetes management; dietary supplements; digital; evidence base; exercise program; experience; functional MRI scan; group intervention; improved; improved functioning; innovation; live stream; mild cognitive impairment; mindfulness; modifiable risk; phase 1 study; physical inactivity; prevent; programs; social; social engagement; trial comparing; virtual

Together Senior Health, Inc. (TOGETHER) is a woman-owned small business that is dedicated to helping older adults with cognitive decline or Alzheimer’s disease and related dementias (ADRD) maintain quality of life and independence by offering innovative, evidence-based, online, livestream, group programs. Our first product on the TOGETHER audio/video platform is Moving TogetherTM—which combines movements to support daily function with mindful body awareness exercises and social engagement and is designed for people with mild ADRD and their caregivers who participate together from home. The primary goal of this Phase II Small Business Innovation Research (SBIR) grant is to expand our product line by developing and testing a comprehensive BRAIN HEALTH TOGETHER program for people living with mild cognitive impairment (MCI). This goal represents a critically important next step for our company from both public health and business perspectives. Older adults with MCI represent a large market with important unmet needs: approximately 20% of older adults (>2.7 million Americans) are currently living with MCI, which places them at increased risk of developing ADRD. There are no medications that can prevent development of ADRD in people with MCI; however, there is growing evidence that behavioral interventions targeting modifiable dementia risk factors—such as physical inactivity, social isolation, and depression—may help improve cognitive function and could potentially delay dementia onset. Our preliminary results suggest that our product, Moving Together is associated with significant improvements in cognitive function, physical function, social isolation, and self-regulation as well as increased default mode network connectivity on pre/post resting state functional magnetic resonance imaging (rs-fMRI) scans in people with MCI. We believe that these benefits would be even greater if Moving Together were combined with a comprehensive brain health coaching program. Therefore, our Specific Aims are to: 1) Work with our Scientific Advisory Board and use humancentered design to develop evidence-based content for Brain Health Together, a 12-week, group-based, livestreaming, digital program that will combine Moving Together with brain health coaching to address modifiable dementia risk factors in people with MCI; 2) Perform a randomized, controlled trial to determine whether the Brain Health Together program improves cognitive function in people with MCI over 12 weeks compared to a Successful Aging comparison group; and 3) Determine whether weekly maintenance classes help to sustain the effects of the Brain Health Together program over 12 weeks after the intervention. If we can demonstrate that BRAIN HEALTH TOGETHER has immediate and sustained cognitive benefits in people with MCI, it will position TOGETHER as a national leader in evidence-based programs to improve quality of life and prevent decline in older adults with cognitive impairment.

共同的高级Health，Inc。（一起）是一家女性拥有的小型企业，致力于帮助 认知能力下降或阿尔茨海默氏病和相关痴呆症（ADRD）的老年人保持生活质量 和独立性，提供创新的，循证的，在线，直播，小组计划。我们的第一个 共同的音频/视频平台上的产品正在移动togethertm，将动作结合到 通过正念的身体意识练习和社交参与来支持日常功能，并专为 有轻度ADRD的人及其照顾者在家中一起参加。这个主要目标 第二阶段小型企业创新研究（SBIR）赠款是通过开发扩展我们的产品线 并针对患有轻度认知的人一起测试全面的大脑健康计划 损害（MCI）。这个目标代表了我们公司的下一步至关重要的下一步 健康和商业观点。 MCI的老年人代表着一个大型市场，有重要的未满足需求： 目前约有20％的老年人（> 270万美国人）生活在MCI中，这使他们处于 增加了ADRD的风险。没有药物可以阻止ADRD的发展 有MCI的人；但是，越来越多的证据表明，行为干预措施针对可修改 痴呆症危险因素（例如身体上的不活动，社会隔离和抑郁）可能有助于改善 认知功能，可能会延迟痴呆发作。我们的初步结果表明我们的产品， 一起移动与认知功能，身体机能，社会的显着改善有关 隔离和自我调节以及增加默认模式网络连接在预/静止状态下 MCI患者的功能磁共振成像（RS-FMRI）扫描。我们相信这些好处 如果将一起移动与全面的大脑健康指导结合在一起，将会更大 程序。因此，我们的具体目的是：1）与我们的科学咨询委员会合作并使用 Humantent的设计，共同开发基于证据的大脑健康内容，一个为基于小组的12周， 直播，数字程序，将与大脑健康教练一起移动以解决 MCI患者的可修改痴呆症危险因素； 2）执行随机对照试验以确定 大脑健康计划是否可以改善MCI患者的认知功能，超过12周 与成功的衰老比较组相比； 3）确定是否每周维护课程 干预后12周内，帮助维持大脑健康的影响。如果可以的话 证明大脑健康共同具有立即和持续的认知益处 具有MCI的人，它将在循证计划中将其定位为国家领导者 改善生活质量并防止认知障碍的老年人下降。