Mayo Clinic Hepatobiliary SPORE Diversity Supplement Dr. Musa Gabere

Mayo Clinic 肝胆 SPORE 多样性补充剂 Dr. Musa Gabere

基本信息

批准号：
10310895
负责人：
MARK A. MC NIVEN
金额：
$ 13.6万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-10 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10310895
关键词：
African Antigens Award Bacterial Infections Bioinformatics Biological Biological Assay Biological Markers Cancer Patient Caring Cholangiocarcinoma Clinic Clinical Trials Collaborations Colorectal Cancer Coupled Data Data Set Development Doctor of Philosophy Eligibility Determination Emerging Technologies Extramural Activities Foundations Funding Genes Genetic Goals Grant Green Card Heat Stroke Hepatobiliary Immunotherapeutic agent Immunotherapy Kenya Learning Legal patent Machine Learning Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of pancreas Master of Science Mathematics Mayo Clinic Cancer Center Mentors Middle East Respiratory Syndrome Minority Musa plant Mycoses Neurology Patients Phase I Clinical Trials Primary carcinoma of the liver cells Prognosis Publishing Research Research Ethics Research Personnel Scholarship Scientist Screening for cancer Secure Series South Africa Supervision Systems Biology Systems Development Therapeutic Agents Training Translational Research Tsetse Flies United States Universities Virotherapy Virus Diseases Visit Work anticancer research antimicrobial peptide artificial neural network base biomarker discovery cancer genetics career doctoral student ethnic minority population exome feature selection hepatobiliary cancer immunotherapeutic virotherapy in silico interest knowledge base mathematical sciences meetings metabolome methylome new technology oncolytic virotherapy parent grant personalized medicine post-doctoral training programs racial minority random forest response support vector machine targeted treatment therapy development transcriptome undergraduate student whole genome

项目摘要

STATEMENT OF CANDIDATE ELIGIBILITY AND DIVERSITY Dr. Musa Gabere is a permanent resident of the United States (Green card number: 063-359-769) of African descent. He completed his undergraduate studies at the University of Nairobi. He then moved to South Africa, where he completed post-graduate diploma, Master of Science and Doctor of Philosophy. Dr. Gabere is interested in applying genetics and bioinformatics approaches to identify common biomarkers that can be used to develop targeted therapies for hepatobiliary cancers. In particular, he will train in understanding the transcriptome changes in hepatocarcinoma treated with immunovirotherapy, a new class of immunotherapeutic. He will be mentored by Dr. Mitesh J. Borad (Primary mentor), Dr. Richard G. Vile (Co- mentor), and Dr. Lewis Roberts (co-mentor) as part of the parent grant 5P50CA210964-03 (P.I. Dr. Richard G. Vile). The overall goal of Dr. Gabere is to pursue research in cancer genetics. Dr. Gabere will participate in various training in Mayo Clinic. These include training in virotherapy, immunotherapy, translational research and ethics. Additionally, there are weekly meetings in cancer, where he can learn and interact with Mayo Clinic Cancer Center senior investigators. In addition, to this, Dr Gabere will have the opportunity to work with large cancer genetics datasets with experts in liver and pancreatic cancer research. These datasets include but not restricted to whole genome, exome, methylome, metabolome and transcriptome for various cancers such as Cholangiocarcinoma. Dr Gabere will also have opportunity to mentor and supervise PhD students and visiting scientists to identify of antigens both in-silico and functional assays. The diversity grant will also allow Dr. Gabere to increase the number of racial and ethnic minorities who participate in biomarker discovery and clinical trials. This will allow Dr Gabere to inform and educate the minorities in the importance of clinical trials and early cancer screening. It is expected that upon receipt of the Diversity Supplement, Dr. Gabere will be able to generate vital data and apply for extramural funding, such as the care award (R21) at the end of his second year.

候选人资格和多样性的声明 Musa Gabere博士是美国的永久居民（绿卡编号：063-359-769）下降。他在内罗毕大学完成了本科学习。然后他搬到南非，他完成了研究生文凭，科学硕士和哲学博士。 Gabere博士有兴趣采用遗传学和生物信息学方法来识别常见的生物标志物可以用来开发针对肝癌的靶向疗法。特别是他会训练了解用免疫疗法治疗的肝癌的转录组变化，这是一类新的免疫治疗。他将受到Mitesh J. Borad博士（主要导师）的指导，Richard G. Vile博士（共同导师）和刘易斯·罗伯茨（Lewis Roberts）博士（Co-entor）作为父母授予5P50CA210964-03的一部分（P.I. Richard G.博士邪恶）。 Gabere博士的总体目标是从事癌症遗传学研究。 Gabere博士将参加各种在梅奥诊所进行培训。其中包括病毒疗法，免疫疗法，转化研究和伦理学的培训。此外，在癌症中每周举行一次会议，他可以在其中学习并与蛋黄酱诊所互动中心高级调查员。此外，Gabere博士将有机会与大型癌症一起工作遗传学数据集与肝脏和胰腺癌研究专家。这些数据集包括但不包括仅限于整个基因组，外显子，甲基组，代谢组和转录组，例如胆管癌。 Gabere博士还将有机会指导和监督博士生并参观科学家确定抗原内硅内和功能测定法。多样性赠款还将允许Gabere博士增加种族和少数民族的数量参加生物标志物发现和临床试验。这将使Gabere博士告知和教育临床试验和早期癌症筛查重要性的少数群体。预计收到多样性补充剂，Gabere博士将能够生成重要数据并申请校外资金，例如第二年结束时，护理奖（R21）。