Somatosensory stimulation therapies for movement disorders

体感刺激疗法治疗运动障碍

• 批准号: 10311109
• 负责人: Dawn Marie Taylor
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10311109
• 关键词: Area; Back; Brain; Chemical Exposure; Chronic; Clinical; Cutaneous; Deep Brain Stimulation; Disease; Dopamine; Effectiveness; Electrodes; Exhibits; Feedback; Frequencies; Future; General Population; Goals; Grant; Hindlimb; Human; Implant; Incidence; Limb structure; Modeling; Monitor; Motor; Motor Activity; Movement Disorders; Muscle; Neurodegenerative Disorders; Neurons; Neurotoxins; Operative Surgical Procedures; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Pathologic; Pathology; Pathway interactions; Patients; Pattern; Performance; Peripheral; Pharmaceutical Preparations; Pharmacology; Pharmacotherapy; Phase; Physiologic pulse; Production; Randomized; Rattus; Records; Risk; Sensory; Signal Transduction; Skin; Somatosensory Receptor; Symptoms; Synapses; Technology; Testing; Therapeutic; Time; Tremor; Veterans; Work; brain surgery; combat; design; excitotoxicity; experience; improved; military veteran; minimally invasive; motor symptom; neural circuit; neural implant; novel; phase change; receptor; relating to nervous system; response; sensory input; side effect; somatosensory; subcutaneous; symptom management; symptomatic improvement

The goal of this project is to develop better ways to treat motor symptoms of Parkinson’s disease. People with Parkinson’s disease typically have higher amounts of synchronization across sensorimotor brain areas especially in the beta bands. This abnormal synchrony is thought to impede the production of normal motor patterns. Breaking up that excess synchrony can potentially improve motor symptoms and may help to renormalize brain network functioning. To that end, somatosensory stimulation will be used in a rat model of Parkinson’s disease to try to disrupt the excess brain network synchrony seen in Parkinson’s disease. Motor improvements and brain network changes will be directly compared when stimulation is used to activate two types of somatosensory receptors: 1) proprioceptive receptors (via electrically induced twitches in limb muscles), and 2) cutaneous receptors (via subcutaneous stimulation to activate the cutaneous receptors directly). Additionally, two types of stimulation patterns will also be compared: 1) a consistent desynchronizing pattern, and 2) a randomly varying pattern. Motor activity will be quantified before, during and after each combination of stimulation options. The stimulation option that improves motor performance the most will then be further assessed to determine whether it’s best to continuously apply that type of stimulation (open loop) or to only turn it on when the brain is exhibiting excess synchrony (closed loop). The results of this study will guide future human testing and could provide a less risky, non- or minimally invasive treatment option with fewer side effects than current stimulation options like deep brain stimulation.

该项目的目的是开发更好的方法来治疗帕金森氏症的运动症状 疾病。患有帕金森氏病的人通常具有更高的同步 跨感觉运动大脑区域，尤其是在β频段中。这种异常同步是 被认为会阻碍正常运动模式的产生。分解超过同步 可以潜在地改善运动症状，并有助于重新统治大脑网络的功能。 为此，帕金森氏病大鼠模型将使用体感刺激来尝试 破坏帕金森氏病中过多的大脑网络同步。发动机 当使用刺激以进行改进和大脑网络变化 激活两种类型的体感受体：1）本体感受受体（通过电气 肢体肌肉中诱导的抽搐）和2）皮肤受体（通过皮下刺激到 直接激活皮肤受体）。此外，两种类型的刺激模式也将 进行比较：1）一种一致的非同步模式，以及2）随机变化的模式。发动机 在每种刺激选项组合组合之前，之中和之后，活动都将进行量化。这 刺激选项可以提高运动性能最多，然后将进一步评估 确定最好是连续应用这种类型的刺激（开放循环）还是仅适用于 当大脑表现出多余的同步（闭环）时，将其打开。这项研究的结果 将指导未来的人类测试，并可能提供较小的，非或微创的风险 治疗选项的副作用少于当前刺激选项，例如深脑 刺激。