2014 Biology of Host-Parasite Interactions Gordon Research Conference

2014年宿主-寄生虫相互作用生物学戈登研究会议

• 批准号: 8716948
• 负责人: STEPHEN L HAJDUK
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-15 至 2014-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8716948
• 关键词: Acquired Immunodeficiency Syndrome; Address; African Trypanosomiasis; Amebic colitis; Area; Biology; Centers for Disease Control and Prevention (U.S.); Chagas Disease; Collaborations; Collection; Communicable Diseases; Communities; Cryptosporidiosis; Development; Disease; Faculty; Fostering; Future; Gender; Health; Helminths; Human; Infection; Learning; Leishmaniasis; Malaria; National Institute of Allergy and Infectious Disease; Opportunistic Infections; Parasites; Parasitic Diseases; Parasitology; Pathogenesis; Pharmaceutical Preparations; Positioning Attribute; Published Comment; Reproduction spores; Research; Research Personnel; Scientist; Secure; Staging; Students; Toxoplasma; Toxoplasmosis; Training; Transplant Recipients; Trichomonas; Tropical Disease; Vaccines; Virulence Factors; Work; base; biodefense; career; congenital infection; meetings; member; neglect; parasitism; pathogen; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) Host-parasite Interactions is the most prominent venue for scientific exchange at the leading edge of modern parasite research. This conference has been consistently at the forefront of the field since its inception in 1981 (originally under the title Parasitism). The conference will focus on new concepts and approaches in the study of parasites and their interaction with humans. This meeting will specifically address mechanisms of pathogenesis both from the viewpoint of parasite virulence factors and also changes in the host associated with infection. This group includes a large number of important disease causing agents with national and global impact. Among these are classical agents of tropical disease including malaria, sleeping sickness, chagas disease, leishmaniasis and amebic dysentery and numerous helminth infections. Together they claim millions of lives around the world. Parasitic disease are also highly prevalent in the U.S. including toxoplasmosis, cryptosporidiosis and trichomiasis. Trichomonas alone causes more than 7 million symptomatic infections each year in the U.S. Toxoplasma causes congenital infection. Some of these diseases are of a particular importance as opportunistic infections in AIDS and transplant patients and a number of parasites (in particular those with spore-like infectious stages) are of biodefense concern and are featured on Appendix B of the CDC/NIAID pathogen list. Numerous important challenges remain largely unmet when facing these diseases. There is currently no effective vaccine available for any human parasite and the options for drug treatment are far from satisfactory. The GRC is highly valued by the community as an opportunity to gain an overview of the entire field, to learn about the most recent and most exciting advances and to discuss and set the national and global research agenda for the future. It is also an important opportunity for trainees to foster their professiona development.

描述（由申请人提供）：戈登研究会议（GRC）宿主-寄生虫相互作用是现代寄生虫研究前沿科学交流的最著名场所。该会议自 1981 年成立以来一直处于该领域的前沿（最初的标题是“寄生主义”）。会议将重点讨论寄生虫及其与人类相互作用研究的新概念和新方法。本次会议将从寄生虫毒力因子以及与感染相关的宿主变化的角度专门讨论发病机制。该组包括大量具有国家和全球影响的重要致病因子。其中包括热带疾病的典型病原体，包括疟疾、昏睡病、恰加斯病、利什曼病和阿米巴痢疾以及多种蠕虫感染。他们共同夺去了全世界数百万人的生命。寄生虫病在美国也非常普遍，包括弓形体病、隐孢子虫病和滴虫病。在美国，仅毛滴虫每年就会引起超过 700 万例有症状的感染。弓形虫会引起先天性感染。其中一些疾病特别重要，因为艾滋病和移植患者的机会性感染以及许多寄生虫（特别是具有孢子样感染阶段的寄生虫）具有生物防御作用，并且在 CDC/NIAID 病原体清单附录 B 中列出。 。面对这些疾病时，许多重要挑战在很大程度上仍未得到解决。目前还没有针对任何人类寄生虫的有效疫苗，并且药物治疗的选择也远不能令人满意。 GRC 受到学术界的高度重视，认为它是一个了解整个领域、了解最新和最令人兴奋的进展以及讨论和制定未来国家和全球研究议程的机会。这也是学员促进职业发展的重要机会。