Assessment of viral loads as markers of disease status in HIV and HPV positive

评估病毒载量作为 HIV 和 HPV 阳性疾病状态的标志

• 批准号: 7648050
• 负责人: Omar Bagasra
• 金额: $ 22.08万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7648050
• 关键词: AIDS related cancer; Acquired Immunodeficiency Syndrome; Address; African American; Age; American; Basic Science; Behavioral; Biological Markers; Blood; Caring; Caucasians; Caucasoid Race; Communicable Diseases; Communities; Community Health; Community Outreach; Complex; Data; Development; Diabetes Mellitus; Disease; Disease Marker; Education; Genotype; HIV; Hand; Head; Health Services Accessibility; Health Status; Health care facility; Healthcare; Herpesviridae; Highly Active Antiretroviral Therapy; Human; Human Herpesvirus 8; Human Papillomavirus; Human papillomavirus 16; Individual; Kaposi Sarcoma; Knowledge; Laboratories; Low income; Measurement; Medical; Messenger RNA; Minority; Molecular Virology; Obesity; Outcome Study; Outreach Research; Pap smear; Participant; Pilot Projects; Play; Population; Prevention; Quality of life; RNA; Race; Rate; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Role; Sexually Transmitted Diseases; Social support; Socioeconomic Status; Stigmata; Translating; Underserved Population; Viral Load result; Woman; disorder prevention; health belief; health disparity; mortality; outreach; outreach program; prevent; social stigma; success; transmission process

In recent years, the overall AIDS and AIDS associated cancer mortality in the U.S. has significantly decreased, but the decrease has not been consistent across all populations. Due to an array of barriers to care, minorities and poor people who are infected with the human immunodeficiency virus type I (HIV) and various other sexually transmitted diseases (i.e., human herpes virus type 8 [HHV-8] and human papillomavirus [HPV]) have not benefited from advances in the treatment of HIV and HIV associated diseases as other groups. Minorities are acquiring HIV (and other sexually transmitted infectious diseases) at much higher rates than observed in Caucasians. African American (AA) women are the fastest growing group of HIV positive individuals. Our proposal addresses this issue by developing a partnership between the researchers, the established health care facilities, community outreach groups and education initiatives to close the gaps in these philosophical differences, realize the limitations, and reach out to the medical community, researcher, as well as the public to reduce the health disparities. It focuses specifically on consolidation of the resources between various groups to maximize health care for the underserved populations in SC. We believe that the outcome of this study will benefit all the underserved groups in the nation The five specific aims of this project are: 1) to establish a molecular virology laboratory to serve as a core research resource for the EXPORT collaborating researchers 2) to collect and provide data on HIV-1 in HIV-1 seropositive individuals recruited for participation in the projects of Drs. Hand and Phillips and Drs. Stoskopf and Geslani, 3) to provide quantitative assessment of HPV 16 and 18 E7 mRNA, sequencing and genotyping of HPV, and HPV viral load from Pap smears collected from the other full research project headed by Drs. Creek and Pirisi, 4) to determine HHV-8 viral loads in HIV-1 seropositive individuals for this research project and then to 5) investigate any correlation(s) between the development of full blown AIDS, and KS.

近年来，与美国相关的总体艾滋病和艾滋病已经大大降低，但在所有人群中的下降并不是一致的。由于护理的一系列障碍，感染了人类免疫缺陷病毒I型（HIV）和其他各种性传播疾病（即人类疱疹病毒8 [HHV-8]和人类乳头状病毒[HPV]）的少数群体和穷人尚未受益于HIV和HIV相关群体的治疗群体。少数族裔以比高加索人观察到的要高得多的艾滋病毒（和其他性传播的感染性疾病）。非裔美国人（AA）妇女是增长最快的艾滋病毒阳性人群。我们的建议通过建立研究人员，既定的医疗保健设施，社区推广小组和教育计划之间的伙伴关系来解决这个问题，以缩小这些哲学差异的差距，实现局限，并与医学界，研究人员以及公众接触以减少健康差异。它专门针对各个群体之间资源的合并，以最大程度地提高SC中服务不足人群的医疗保健。我们认为，这项研究的结果将使全国所有服务不足的群体受益。该项目的五个特定目标是：1）建立一个分子病毒学实验室，以作为导出合作研究人员的核心研究资源2）收集并提供有关HIV-1中的HIV-1数据数据，以招募HIV-1血清中的人参与DRS的项目。手和菲利普斯和博士。 Stoskopf和Geslani，3）提供了对HPV 16和18 E7 mRNA的定量评估，HPV的测序和基因分型以及从DRS领导的其他完整研究项目中收集的PAP Smears的HPV病毒负载。小溪和皮里西（Pirisi），4）确定HHV-8 HHV-8 HHV-1血清阳性的病毒载荷 该研究项目的个人，然后到5）研究全面吹动艾滋病和KS之间的任何相关性。