Positronium lifetime imaging using TOF PET

使用 TOF PET 进行正电子寿命成像

基本信息

批准号：
10443873
负责人：
JINYI QI
金额：
$ 19.63万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-02 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10443873
关键词：
Address Applications Grants Biochemical Cardiology Cardiovascular Diseases Clinic Computer Simulation Diagnostic Neoplasm Staging Dimensions Dreams Effectiveness Electrons Future Human Development Human body Hydrogen Peroxide Hydroxyl Radical Hypoxia Image Imaging Phantoms Imaging Techniques Injections Malignant Neoplasms Measurement Measures Medical Imaging Medical center Methods Molecular Neurology Oncology Oxygen Patient-Focused Outcomes Photons Positron Positron-Emission Tomography Property Publishing Radiation therapy Radioactive Tracers Radioisotopes Resolution Sampling Scanning Techniques Technology Time Tissues Tracer Use Effectiveness base cancer therapy chemotherapy detection sensitivity detector effective therapy experimental study fluorescence lifetime imaging human disease human imaging image reconstruction imaging modality improved in vivo in vivo imaging molecular imaging nervous system disorder outcome prediction photon-counting detector pressure radioresistant radiotracer reconstruction simulation standard measure treatment planning tumor tumor hypoxia

项目摘要

Project Summary/Abstract Positron emission tomography (PET) is a high-sensitivity molecular imaging modality widely used in oncology, neurology, and cardiology, with the ability to observe molecular-level activities inside a living body through the injection of specific radioactive tracers with positron emitters. Recently it has been shown that the lifetime of positronium, a metastable state formed by a pair of electron and positron, is sensitive to the microenvironment of the surrounding tissue, such as oxygen pressure. Such information is valuable for cancer staging and treatment planning. However, currently there is no practical method to imaging the positronium lifetime at a spatial resolution matching that of PET due to the limited photon detection sensitivity and lack of proper image reconstruction method. This proposal addresses these problems by developing a statistically based image reconstruction method for positronium lifetime imaging (PLI) and combining it with the newly developed total- body EXPLORER PET scanner at UC Davis. We will demonstrate the effectiveness of the method using phantom experiments on the EXPLORER scanner. The advantage of the PLI is that the lifetime measurement is independent of the tracer concentration and can be used together with standard PET imaging. The combination of PLI and PET will add another dimension to current PET imaging and provide useful information for understanding the microenvironment of the tissue for studying various human diseases.

项目摘要/摘要正电子发射断层扫描（PET）是一种高灵敏的分子成像方式，广泛用于肿瘤学，神经病学和心脏病学，能够通过观察活体内的分子级活动。注射特定的放射性示踪剂，并发出正电子。最近，已经证明了正电子是由一对电子和正电子形成的亚稳态，对微环境敏感周围组织的氧气压力。此类信息对于癌症分期和治疗计划。但是，目前尚无实际方法来对阳性寿命进行成像由于光子检测灵敏度有限和缺乏适当的图像，与PET相匹配的空间分辨率与PET的分辨率相匹配重建方法。该建议通过开发基于统计的图像来解决这些问题正电子寿命成像（PLI）的重建方法，并将其与新开发的总计结合加州大学戴维斯分校的Body Explorer Pet扫描仪。我们将使用该方法的有效性探索器扫描仪上的幻影实验。 PLI的优点是寿命测量与示踪剂浓度无关，可以与标准PET成像一起使用。这 PLI和PET的组合将为当前的PET成像增加另一个维度，并提供有用的信息用于理解组织的微环境，以研究各种人类疾病。