Nutrition, Exercise and phenotype Testing Core

营养、运动和表型测试核心

• 批准号: 10425295
• 负责人: Jeffrey F Horowitz
• 金额: $ 17.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425295
• 关键词: Accelerometer; Adipose tissue; Adult; Aerobic Exercise; Anthropometry; Area; Behavior; Biopsy; Blood; Blood Pressure; Body Composition; Cardiometabolic Disease; Child; Chronic; Clinical; Clinical Research; Consult; Consultations; Consumption; Data Set; Development; Dietary Intervention; Disease; Dual-Energy X-Ray Absorptiometry; Educational Intervention; Energy Metabolism; Ensure; Exercise; Fasting; Glucose Clamp; Goals; Human; Human Resources; Infrastructure; Inpatients; Institutes; Intervention; Intervention Trial; Isotopes; Laboratories; Measurement; Metabolic; Methodology; Methods; Michigan; Nutrition Assessment; Nutritional; Obesity; Obesity associated disease; Outpatients; Participant; Patient Self-Report; Phenotype; Physical activity; Physical assessment; Physiological; Procedures; Protocols documentation; Reproducibility; Research; Research Design; Research Personnel; Research Support; Research Training; Rest; Services; Skeletal Muscle; Standardization; Structure; Supervision; Techniques; Testing; Tissue Banks; Tracer; Work; clinical phenotype; community setting; design; dietary; exercise intervention; exercise training; human subject; insight; laboratory experiment; metabolic abnormality assessment; metabolic phenotype; new technology; nutrition; obesity in children; obesity treatment; oral glucose tolerance; organizational structure; population based; response; satisfaction; testing services; tool; translational study

Abstract/Summary – NExT Core The overall objective of the Nutrition, Exercise and phenotype Testing (NExT) core of MNORC (formerly the “Human Phenotyping Core” (HPC) is to enhance and expand the research capabilities of MNORC investigators performing clinical and translational studies related to nutrition, obesity, and/or obesity-related disorders in humans. The NExT core accomplishes this goal by: 1) Provide consultation services to translational, clinical and population-based investigators regarding appropriate assessment, testing and/or intervention approaches for their studies related to nutrition, physical activity/exercise, obesity, or obesity-related cardio- metabolic disorders, 2) offering expertise and infrastructure for sophisticated and standardized physiologic testing of human subjects, including children and adults 3) providing services to directly assist researchers to conduct their nutritional and/or physical activity/exercise interventions in human subjects, and 4) assisting in the development of new techniques or acquire new technologies for human metabolic phenotyping. In addition to offering a wide array of relatively “standard” phenotypic measurements (e.g., anthropometry and body composition (DXA, PeaPod), blood pressure, fasting blood work, oral glucose tolerance, nutritional and physical activity assessments via self reports and objective methods (test meals, accelerometry), and aerobic fitness assessments) the NExT core also offers several more involved procedures to more thoroughly assess the metabolic phenotype (e.g., hyperinsulinemic-euglycemic clamp, isotope-tracer metabolic studies, resting energy expenditure, skeletal muscle and adipose tissue biopsies). Before beginning their studies, MNORC investigators may consult with expert NExT core personnel to gain insights on how the available methodologies may help them to test their hypotheses, and potentially expand their research questions using the tools made available to them through the Core. NExT core personnel also consult with MNORC investigators to help optimize their study designs and their research intervention strategies/approaches. The NEXT core also directly assists MNORC investigators to conduct their obesity/nutritional interventions by providing services such as: nutritional consultations with study participants, supervision of exercise training interventions, assessment of physical activity and dietary behaviors during an intervention, as well as assistance with conducting interventions specifically tailored to each research participant. Overall, the services of the NExT core provide well-controlled and standardized phenotypic testing, state-of-the-art techniques for “deeper” phenotype assessment, as well as assistance to conduct well-controlled research interventions, all of which greatly enhance and expand on existing approaches used by researchers in the areas of nutrition and obesity in children and adults.

摘要/摘要 - 下一个核心 营养，运动和表型测试的总体目标（下一个）MNORC的核心 （以前是“人类表型核心”（HPC）是为了增强和扩展研究 MNORC研究人员进行临床和翻译研究的能力 人类的营养，肥胖和/或与肥胖有关的疾病。下一个核心实现了这一目标 目标作者：1）提供咨询服务以翻译，临床和人群 调查人员有关其适当评估，测试和/或干预方法的调查人员 与营养，体育锻炼/运动，肥胖或与肥胖相关的心脏相关的研究 代谢疾病，2）提供精致和标准化的专业知识和基础设施 人类受试者的生理测试，包括儿童和成人3）提供服务 直接帮助研究人员进行营养和/或体育锻炼/锻炼 对人类受试者的干预措施，以及4）协助开发新技术或 获取用于人类代谢表型的新技术。除了提供广泛的阵列 相对“标准”表型测量（例如，人体测量法和身体组成 （DXA，PEAPOD），血压，空腹血液工作，口服葡萄糖耐受性，营养和 通过自我报告和客观方法评估体育锻炼（试餐， 加速度计）和有氧健身评估）下一个核心还提供了更多 涉及的程序以更彻底评估代谢表型（例如， 高胰岛素血糖夹，同位素跟踪代谢研究，静息能 支出，骨骼肌和脂肪组织活检）。在开始学习之前， MNORC调查人员可以咨询专家下一个核心人员，以了解如何了解 可用的方法学可以帮助他们检验其假设，并有可能扩大他们的假设 使用通过核心提供的工具进行的研究问题。下一个核心 人员还咨询MNORC调查人员，以帮助优化其研究设计及其 研究干预策略/方法。下一个核心也直接有助于MNORC 调查人员通过提供以下服务来进行肥胖/营养干预措施： 与研究参与者的营养咨询，锻炼培训干预措施的监督， 评估干预期间的体育锻炼和饮食行为 协助进行专门针对每个研究参与者量身定制的干预措施。 总体而言，下一个核心的服务提供了控制良好的标准化表型 测试，“更深”表型评估的最新技术，以及帮助 进行良好控制的研究干预措施，所有这些干预措施都大大增强和扩展 研究人员在儿童营养和肥胖领域使用的现有方法以及 成年人。