Whole genome sequencing laboratory, procurement of supplies and reagents and equipment maintenance for surveillance, outbreak assessment, and data mining.

全基因组测序实验室、采购用品和试剂以及用于监测、疫情评估和数据挖掘的设备维护。

基本信息

批准号：
10424403
负责人：
Udeni B. R. Balasuriya
金额：
$ 7.4万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10424403
关键词：
Whole genome sequencing laboratory procurement

项目摘要

Summary: Louisiana Animal Disease Diagnostic Laboratory (LADDL) is one of four whole genome sequencing laboratories selected by Vet-LIRN to participate in a pilot project using Whole Genome Sequencing (WGS) to monitor antimicrobial resistance in zoonotic pathogens. Long term goals of this proposal are to add genomic data from animal or animal feed bacterial isolates to National Antimicrobial Resistance Monitoring System and to develop a rapid response network for accurate resolution of putative animal food- borne disease outbreaks. This project has 3 specific aims: 1. Provide funding for supplies, reagents and equipment maintenance for continuation of Vet-LIRN’s pilot Antimicrobial Resistance (AMR) and Sequencing Project. 2. Through whole genome sequencing: a) provide surveillance of antimicrobial resistance in animal feeds and in infected animals; b) build reference databases to aid in solving foodborne outbreaks more efficiently; and c) aid foodborne disease investigations by linking food sources and clusters of disease. 3. Provide support and testing for diagnostic cases or pathogens of interest referred by CVM-Vet-LIRN. Antimicrobial resistance is a constant and growing threat to both human and animal health. Whole genome sequencing is one of the recent and more powerful tools to study it and monitor its development and progression. Sequencing also has shown excellent utility in the epidemiological investigations of food-borne disease outbreaks.

概括：路易斯安那动物疾病诊断实验室（LADDL）是整个基因组之一由兽医LIRN选出的测序实验室使用全基因组测序（WGS），以监测人畜共患病中的抗菌素耐药性病原体的长期目标是添加动物的基因组数据动物饲料的双脚菌菌株是国家抗菌素耐药性监测系统并建立一个快速待遇网络，以准确解决推定的动物食品 - 疾病爆发。供应，试剂和设备维护，以抗兽医飞行员的飞行员抗菌抗性（AMR）和测序项目。测序：a）在动物饲料和中提供对抗菌耐药性的监视感染动物； b）建立参考数据库以帮助解决食品爆发更有效的； c）通过将食物来源和疾病群。 CVM-VET-LIRN提到的兴趣。抗菌耐药性是对人和动物的一致且日益严重的威胁整个基因组测序是最近的研究并监视其发展和进展。在粮食传播暴发的流行病学研究中的出色效用。