COBRE Phase III: Delaware Center for Neuroscience Research

COBRE III 期：特拉华神经科学研究中心

基本信息

批准号：
10424999
负责人：
MELISSA A HARRINGTON
金额：
$ 114.61万
依托单位：
DELAWARE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10424999
关键词：
Animals Applications Grants Award Basic Science Behavior Biomedical Research Brain Brain imaging Caliber Cells Centers of Research Excellence Cognition Collaborations Communities Core Facility Data Delaware Development Disease Education Electrodes Electrophysiology (science)Ensure Environment Exploratory/Developmental Grant for Diagnostic Cancer Imaging Faculty Faculty Recruitment Feeling Fostering Foundations Funding Genetic Goals Grant Historically Black Colleges and Universities Human Human Resources Image Infrastructure Injury Institution Invertebrates Investments Lead Longevity Magnetic Resonance Imaging Memory Mentored Research Scientist Development Award Mentors Minority Modeling Molecular Nervous System Physiology Neurosciences Neurosciences Research Phase Physiology Pilot Projects Program Development Publications Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Support Resources Rodent Rodent Model Services Slice Structure Structure-Activity Relationship Study Section Thinking Time Tissues Training Training Activity Translational Research United States National Institutes of Health Universities Vocational Guidance base biomedical imaging career diversity and equity experience faculty research human subject improved innovation insight inter-institutional meetings member neuroimaging non-invasive imaging operation patch clamp programs public health relevance relating to nervous system research data dissemination skills success symposium undergraduate student

项目摘要

Overall Proposal Summary The Delaware Center for Neuroscience Research, established in 2012 with a COBRE award, is a collaboration between Delaware State University (DSU) and the University of Delaware (UD). Our unique Center brings together faculty and research resources from two very different institutions: a minority-serving, undergraduate university with an emerging strength in neuroscience research (DSU), and the state’s flagship research university (UD). Phase II of our Neuroscience Center COBRE was focused strengthening our infrastructure for neuroscience research, and to continue to support the research and professional development of early stage investigators that included Project Leads, Pilot Grant PIs, and new faculty who were hired at DSU with COBRE support. Our Center has been very successful with over 175 publications by COBRE-supported researchers, six Project Leads “graduated” into R01 support, three pilot investigator graduated to NSF grants including a CAREER award, and new faculty recruited to DSU with COBRE support winning K01 and R21 awards. During Phase II our institutions made significant investments in the research infrastructure for neuroscience. The University of Delaware established the Center for Biomedical and Brain Imaging with a 3T scanner for human magnetic resonance imaging, and a 9.4T scanner with small bore magnet for MRI with rodent models. Delaware State University established a Cell Electrophysiology Core facility to provide patch clamp, multi-electrode and automated patch clamp services with cells and tissue slices to help neuroscience investigators answer their research questions. Our phase III project will strengthen both our Center and neuroscience research in Delaware by transitioning the core resources and biomedical research activities our Neuroscience Center into independence and sustainability. The overarching scientific goal of our Neuroscience Center is to bring together and support neuroscientists working at multiple scales, from human subjects to rodent and invertebrate models to improve our understanding of the dynamic function of the brain. During Phase III we will pursue three specific aims for our Center: 1) involving a new group of investigators in the Center’s integrated mentoring and professional development program with a pilot grant program that will help junior faculty become independent, externally-funded researchers; 2) strengthening the research infrastructure and capacity in Delaware by supporting our research core facilities to transition to sustainability; and 3) to develop the Delaware Center for Neuroscience Research as a supportive, sustainable scientific community focused on investigating dynamic structure-function relationships in the brain. Continuing this COBRE program will have two significant long-term benefits. First, we will build on our success to support more Delaware neuroscientists to achieve NIH funding for their research on understanding the brain. Second, as the only COBRE based at an Historically-Black institution, our project has a uniquely significant impact in supporting diversity, equity and inclusion in the IDeA program and biomedical research in general.

总体方案概括特拉华州神经科学研究中心成立于 2012 年， COBRE 奖是特拉华州立大学 (DSU) 与特拉华大学 (UD) 我们独特的中心汇集了教师和研究人员。来自两个截然不同的机构的资源：一个为少数族裔服务的本科生在神经科学研究（DSU）方面具有新兴实力的大学，以及该州的我们的旗舰研究大学 (UD) 神经科学中心 COBRE 的第二期重点是加强我们的研究。神经科学研究的基础设施，并继续支持早期神经科学研究和专业发展阶段研究人员，包括项目负责人、试点资助 PI 以及通过 COBRE 在 DSU 聘用的新教员我们的中心非常成功，由 COBRE 支持的研究人员发表了超过 175 篇出版物，其中有 6 个项目。领导“毕业”进入 R01 支持，三名试点研究员毕业获得 NSF 拨款，包括职业奖，以及在 COBRE 的支持下，DSU 招募的新教师获得了 K01 和 R21 奖项。在第二阶段，我们的机构对神经科学研究基础设施进行了大量投资。特拉华大学建立生物医学和脑成像中心，配备人体 3T 扫描仪磁共振成像，以及带有小口径磁铁的 9.4T 扫描仪，用于特拉华州啮齿动物模型的 MRI。大学建立了细胞电生理学核心设施，提供膜片钳、多电极和自动化使用细胞和组织切片提供膜片钳服务，帮助神经科学研究人员回答他们的研究问题。我们的第三阶段项目将通过转变核心技术来加强我们在特拉华州的中心和神经科学研究我们的神经科学中心的资源和生物医学研究活动变得独立和可持续。我们神经科学中心的首要科学目标是聚集和支持神经科学家在从人类受试者到啮齿动物和无脊椎动物模型的多个尺度上开展工作，以提高我们对在第三阶段，我们将为我们的中心追求三个具体目标：1）涉及该中心综合指导和专业发展计划的新研究人员小组与试点资助计划将帮助初级教师成为独立的、外部资助的研究人员 2) 加强通过支持我们的研究核心设施向可持续发展过渡，特拉华州的研究基础设施和能力； 3) 将特拉华神经科学研究中心发展成为一个支持性的、可持续的科学界专注于研究大脑的动态结构与功能关系。继续实施这一 COBRE 计划将带来两个重大的长期好处：首先，我们将在我们的基础上再接再厉。成功支持更多特拉华州神经科学家为他们了解大脑的研究获得 NIH 资助。其次，作为唯一一个以历史悠久的黑人机构为基础的 COBRE，我们的项目在以下领域具有独特的重大影响：支持 IDeA 计划和生物医学研究的多样性、公平性和包容性。