STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo

评估环境潜力的研究

基本信息

批准号：
10421164
负责人：
FLORENCE BURLESON
金额：
$ 170.27万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-13 至 2021-08-12
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10421164
关键词：
Affect Animals Antibody Response Antigens Archives Aromatic Compounds Autoimmune Diseases Bone Marrow Chemical Agents Chemicals Communicable Diseases Complex Contracts Cytology Data Analyses Data Reporting Dermal Development Disease Resistance Event Exposure to Food Additives Health Health Hazards Hematopoietic Human Hypersensitivity Immunologic Techniques Immunologics Immunotoxicology In Vitro Individual Measures Methods Molecular National Toxicology Program Neoplasms Pharmaceutical Preparations Predictive Value Reporting Research Resistance Sampling Structure Testing Therapeutic Agents Toxic effect Xenobiotics carcinogenicity developmental toxicity dietary supplements environmental agent exposed human population immune function immune system function immunopathology immunoregulation immunotoxicity in vivo in vivo evaluation inorganic phosphate neurotoxicity programs reproductive toxicity respiratory response

项目摘要

The NTP PAC Mixtures Assessment Program (PAC-MAP) provides the framework for assessing a breadth of individual polycyclic aromatic compounds (PACs), defined PAC mixtures, and complex PAC-containing environmental samples using an in vitro/short-term in vivo testing battery that includes a broad spectrum of endpoints. Select PACs have been associated with a wide range of toxicities (carcinogenicity, immunotoxicity, reproductive and developmental toxicity, neurotoxicity) and a complicated array of mechanisms of action. In particular, many PACs have been associated with suppression of humoral immune function and immunotoxicity has been identified as an informative parameter for estimating the carcinogenic potential of PACs. As part of the potential testing battery to predict mixture effects, we have examined the potential for 13 individual PACs and 3 mixtures to modulate the antigen specific antibody response and affect bone marrow cytology. No in vivo immunotoxicology studies were started in FY21 and efforts were focused on data analysis and reporting/archiving of studies conducted in previous contract years. BRT provided 4 final reports and 3 draft reports for individual PAC-MAP immunotoxicity studies in FY21. BRT completed an additional 5 reports and provided 2 draft reports for immunopathology studies of the PAC MAP chemicals. The final report for the developmental immunotoxicology studies on Tris (Chloropropyl) phosphate (TCPP) was also completed in FY21. In addition, BRT closed the immunopathology study for MPEP, and draft reports for the immunotoxicity and disease resistances studies were reviewed by the NTP.

NTP PAC混合物评估计划（PAC-MAP）提供了评估单个多环芳族化合物（PACS），定义的PAC混合物和复杂含PAC PAC的环境样品的框架，该框架使用体外/短期内的体内测试电池，其中包括范围的范围。精选的PACS与广泛的毒性（致癌性，免疫毒性，生殖和发育毒性，神经毒性）和复杂的作用机理有关。特别是，许多PAC与抑制体液免疫功能有关，并且已经将免疫毒性确定为估计PAC的致癌潜力的信息参数。作为预测混合物效应的潜在测试电池的一部分，我们检查了13个单个PAC和3种混合物的潜力，以调节抗原特异性抗体反应并影响骨髓细胞学。在FY21中没有开始体内免疫毒理学研究，并且努力专注于以前合同年份进行的研究和报告/归档。 BRT在FY21中提供了4个最终报告和3个针对单个PAC-MAP免疫毒性研究的报告草案。 BRT完成了另外5项报告，并提供了2种针对PAC地图化学物质的免疫病理学研究的报告草案。在FY21中，还完成了关于TRI（氯丙基）磷酸盐（TCPP）的发育免疫毒理学研究的最终报告。此外，BRT关闭了用于MPEP的免疫病理学研究，NTP审查了免疫毒性和抗病性研究的报告草案。