STUDIES TO EVALUATE THE POTENTIAL FOR ENVIRONMENTAL&THERAPEUTIC AGENTS TO INDUCE IMMUNOTOXICITY - In vivo

评估环境潜力的研究

基本信息

批准号：
10906727
负责人：
FLORENCE BURLESON
金额：
$ 69.26万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-13 至 2024-08-12
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10906727
关键词：
Affect Animals Antibody Response Antigens Archives Aromatic Compounds Autoimmune Diseases Bone Marrow Chemical Agents Chemicals Communicable Diseases Complex Contracts Cytology Data Analyses Data Reporting Dermal Development Disease Resistance Event Exposure to Food Additives Health Health Hazards Hematopoietic Human Hypersensitivity Immunologic Techniques Immunologics Immunotoxicology In Vitro Individual Measures Methods Molecular National Toxicology Program Neoplasms Parameter Estimation Pharmaceutical Preparations Predictive Value Reporting Research Resistance Sampling Structure Testing Therapeutic Agents Toxic effect Xenobiotics carcinogenicity developmental toxicity dietary supplements environmental agent exposed human population immune function immune system function immunopathology immunoregulation immunotoxicity in vivo in vivo evaluation neurotoxicity programs reproductive toxicity respiratory response

项目摘要

The Division of Translation Toxicology (DTT) PAC Mixtures Assessment Program (PAC-MAP) provides the framework for assessing a breadth of individual polycyclic aromatic compounds (PACs), defined PAC mixtures, and complex PAC-containing environmental samples using an in vitro/short-term in vivo testing battery that includes a broad spectrum of endpoints. Select PACs have been associated with a wide range of toxicities (carcinogenicity, immunotoxicity, reproductive and developmental toxicity, neurotoxicity) and a complicated array of mechanisms of action. Many PACs have been associated with suppression of humoral immune function and immunotoxicity has been identified as an informative parameter for estimating the carcinogenic potential of PACs. As part of the potential testing battery to predict mixture effects, we have examined the potential for 13 individual PACs and 3 mixtures to modulate the antigen specific antibody response and affect bone marrow cytology. No in vivo immunotoxicology studies were started in FY23 and efforts were focused on reporting/archiving of studies conducted in previous contract years. BRT provided 2 final reports for PAC Mixtures completing the reporting of those studies. BRT completed an additional 3 draft reports for studies of the Immunotoxicity of Echinacea and Bisphenol F with final reports to be completed in contract year 10. In addition, BRT contributed leadership, data analysis and writing for 6 manuscripts, 3 of which were accepted for publication in FY23. Two manuscripts are in the NIH clearance process and several papers from the PAC-MAP studies are in preparation.

翻译毒理学（DTT）PAC混合物评估程序（PAC-MAP）的分裂提供了评估单个多环芳族化合物（PACS），定义的PAC混合物和复杂含PAC的环境样品的框架，该框架使用体外/短期的Vivo测试电池，其中包括宽阔的终点。精选的PACS与广泛的毒性（致癌性，免疫毒性，生殖和发育毒性，神经毒性）和复杂的作用机理有关。许多PAC与抑制体液免疫功能有关，并且免疫毒性已被确定为估计PAC的致癌潜力的信息参数。作为预测混合物效应的潜在测试电池的一部分，我们检查了13个单个PAC和3种混合物的潜力，以调节抗原特异性抗体反应并影响骨髓细胞学。 23财年没有开始体内免疫毒理学研究，并致力于报告/归档于以前的合同几年进行的研究。 BRT提供了2个完成这些研究报告的PAC混合物的最终报告。 BRT完成了3份报告草案，以研究紫锥菊和双酚F的免疫毒性，并在第10年完成最终报告。此外，BRT还为6种手稿贡献了领导，数据分析和写作，其中3个手稿也接受了233财年的出版。 NIH清除过程中有两个手稿，而PAC-MAP研究的几篇论文正在准备。