African Breast Cancer - Disparities in Outcomes - Plus (ABC-DO Plus)

非洲乳腺癌 - 结果差异 - Plus (ABC-DO Plus)

基本信息

批准号：
10416101
负责人：
Isabel Dos Santos Silva
金额：
$ 32.89万
依托单位：
INTERNATIONAL AGENCY FOR RES ON CANCER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10416101
关键词：
Address Affect Africa South of the Sahara African Aftercare Biological Breast Cancer Patient Breast Cancer Prevention Breast Cancer survivor Breast Cancer survivorship Cancer Etiology Cancer Survivor Cessation of life Characteristics Clinical Collaborations Collection Complement Country Cultural Diversity Data Diagnosis Diagnostic Disease Early Diagnosis Economics Ensure Epidemiology Ethics Gene Expression Profile Goals Guidelines HIV Healthcare Systems Hospitals Hygiene Income Individual Institution International International Agency for Research on Cancer Intervention Investigation Legal London Malignant Neoplasms Mammary Neoplasms Molecular Molecular Profiling Namibia Nigeria Obesity Outcome Pathologic Patients Politics Prevalence Prognostic Factor Prospective Studies Quality of life Reporting Reproduction Research Research Infrastructure Schools Severities South Africa Standardization Survival Rate Survivors Therapeutic Time Treatment Side Effects Tropical Medicine Tumor Subtype Uganda Woman Women&apos s Health Zambia base black women breast cancer diagnosis breast cancer survival cancer care cancer diagnosis cancer health disparity cancer subtypes cancer therapy cancer type cohesion cohort comorbidity evidence base experience follow-up health related quality of life high body mass index improved insight mHealth malignant breast neoplasm molecular subtypes neglect novel oncology service prospective recruit social culture social inequality socioeconomic disparity socioeconomic diversity socioeconomics success survival disparity survival prediction survivorship treatment duration tumor tumor heterogeneity

项目摘要

Project Summary Breast cancer is the most common type of cancer diagnosed and the second cause of cancer death in sub-Saharan African women. The few studies on breast cancer survival in this region reported low short-term survival rates, but none were able to comprehensively address reasons for low survival, how to improve survival, nor assess five-year and longer-term survival and survivorship. Further, the impact of more aggressive molecular subtypes, common in women of African-descent, on breast cancer survival in sub-Saharan Africa has not yet been investigated. The African Breast Cancer-Disparities in Outcomes (ABC-DO) study is a five-country sub-Saharan African breast cancer cohort initiated in 2014. During 3 years of recruitment, over 2100 women were recruited in Uganda, Nigeria, Zambia, Namibia, and South Africa. In the proposed project, ABC-DO-Plus, we will build on ABC-DO – namely the established collaborations, research staff, tumor collections, ethical and legal permissions; and novel and successful mobile-Health (mHealth)-implemented follow-up – to actively follow-up women for a further 2 years to 5 years post-diagnosis, examine for the first time 5-year survival overall and by key prognostic factors, molecular subtypes, treatment availability, affordability and compliance, socioeconomic determinants and comorbidities present in this setting, particularly high BMI and HIV. Breast cancer survivorship research, i.e. the health of women with breast cancer post- treatment, has largely been neglected in sub-Saharan Africa. ABC-DO-Plus will examine, for the first time, longitudinal changes in health-related quality of life up to 5 years after a woman’s breast cancer diagnosis. ABC-DO-Plus will inform interventions needed to mitigate the excessive number of deaths of women with the disease, and improve the quality-of-life of survivors. Utilizing a within-African framework of five countries with different cancer care politics, but also representing individual socioeconomic and cultural diversity, will enable comparisons across settings and hereby identification of modifiable factors influencing BC survival. Furthermore, its findings on the proportions of more aggressive tumor molecular subtypes, and how these may affect survival, as well as on the impact on survival of comorbidities such as HIV, will be of relevance to other black women in the US and elsewhere. The success of the proposed ABC-DO-Plus, and its manifold goals, will be ensured through continuity of the experience of the previous 4+ years’ ABC-DO fieldwork, its established research infrastructure, and the efficient mHealth follow-up approach of this unique cohort.

项目概要乳腺癌是最常见的癌症类型，也是导致乳腺癌的第二大原因撒哈拉以南非洲女性癌症死亡的研究很少。该地区报告短期生存率较低，但没有一个地区能够全面解决生存率低的原因，如何提高生存率，也不评估五年和更长期的生存率此外，更具侵略性的分子亚型的影响，在女性中很常见。非洲人后裔对撒哈拉以南非洲乳腺癌生存率的影响尚未得到调查。非洲乳腺癌结果差异 (ABC-DO) 研究是一项针对五个国家的研究撒哈拉以南非洲乳腺癌队列于 2014 年启动。在 3 年的招募过程中，超过乌干达、尼日利亚、赞比亚、纳米比亚和南非招募了 2100 名女性。拟议的项目 ABC-DO-Plus，我们将建立在 ABC-DO 的基础上——即已建立的合作、研究人员、肿瘤收集、伦理和法律许可；成功的移动医疗 (mHealth) 实施的后续行动 – 积极对女性进行后续行动诊断后 2 年至 5 年，首次检查 5 年总体生存率并通过关键预后因素、分子亚型、治疗可用性、负担能力和依从性，在这种情况下存在失业决定因素和合并症，特别是高体重指数和艾滋病病毒。乳腺癌生存研究，即乳腺癌女性术后的健康状况 ABC-DO-Plus 将针对撒哈拉以南非洲地区的治疗进行研究。第一次，女性乳房发育后 5 年内健康相关生活质量的纵向变化癌症诊断。 ABC-DO-Plus 将告知减少死亡人数过多所需的干预措施减少患有这种疾病的妇女，并利用非洲内部的努力提高幸存者的生活质量。具有不同癌症护理政治的五个国家的框架，但也代表个人社会经济和文化多样性，将能够进行跨环境的比较，特此确定影响 BC 存活的可改变因素。此外，其关于更具侵袭性的肿瘤分子亚型比例的发现，这些可能如何影响生存，以及合并症对生存的影响，例如艾滋病毒将与美国和其他地方的其他黑人女性相关。将确保拟议的 ABC-DO-Plus 及其多重目标的成功通过延续过去 4 年多的 ABC-DO 实地工作经验，建立了研究基础设施，以及这个独特群体的高效移动医疗后续方法。