African Breast Cancer - Disparities in Outcomes - Plus (ABC-DO Plus)

非洲乳腺癌 - 结果差异 - Plus (ABC-DO Plus)

• 批准号: 10605293
• 负责人: Isabel Dos Santos Silva
• 金额: $ 33.72万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605293
• 关键词: Address; Affect; Africa South of the Sahara; African; African ancestry; Aftercare; Biological; Breast Cancer Patient; Breast Cancer Prevention; Breast Cancer survivor; Breast Cancer survivorship; Cancer Etiology; Cancer Survivor; Cessation of life; Characteristics; Clinical; Collaborations; Collection; Complement; Country; Cultural Diversity; Data; Dedications; Diagnosis; Diagnostic; Disease; Early Diagnosis; Economics; Ensure; Epidemiology; Ethics; Ethnic Origin; Gene Expression Profile; Goals; Guidelines; HIV; Healthcare Systems; Hospitals; Hygiene; Income; Individual; Institution; International; International Agency for Research on Cancer; Intervention; Investigation; Legal; London; Malignant Neoplasms; Mammary Neoplasms; Molecular; Molecular Profiling; Namibia; Nigeria; Obesity; Outcome; Outcome Study; Patients; Politics; Prevalence; Prognostic Factor; Prospective Studies; Quality of life; Reporting; Reproduction; Research; Research Infrastructure; Schools; Severities; South Africa; Standardization; Survival Rate; Survivors; Therapeutic; Time; Treatment Side Effects; Tropical Medicine; Tumor Subtype; Uganda; Woman; Women' s Health; Zambia; black women; breast cancer diagnosis; breast cancer survival; cancer care; cancer diagnosis; cancer health disparity; cancer subtypes; cancer type; cohort; comorbidity; economic determinant; evidence base; experience; follow-up; health related quality of life; high body mass index; improved; insight; mHealth; malignant breast neoplasm; molecular subtypes; neglect; novel; oncology service; prospective; recruit; social culture; social disparities; socioeconomic disparity; socioeconomics; success; survival disparity; survival prediction; survivorship; treatment duration; tumor; tumor heterogeneity

Project Summary Breast cancer is the most common type of cancer diagnosed and the second cause of cancer death in sub-Saharan African women. The few studies on breast cancer survival in this region reported low short-term survival rates, but none were able to comprehensively address reasons for low survival, how to improve survival, nor assess five-year and longer-term survival and survivorship. Further, the impact of more aggressive molecular subtypes, common in women of African-descent, on breast cancer survival in sub-Saharan Africa has not yet been investigated. The African Breast Cancer-Disparities in Outcomes (ABC-DO) study is a five-country sub-Saharan African breast cancer cohort initiated in 2014. During 3 years of recruitment, over 2100 women were recruited in Uganda, Nigeria, Zambia, Namibia, and South Africa. In the proposed project, ABC-DO-Plus, we will build on ABC-DO – namely the established collaborations, research staff, tumor collections, ethical and legal permissions; and novel and successful mobile-Health (mHealth)-implemented follow-up – to actively follow-up women for a further 2 years to 5 years post-diagnosis, examine for the first time 5-year survival overall and by key prognostic factors, molecular subtypes, treatment availability, affordability and compliance, socioeconomic determinants and comorbidities present in this setting, particularly high BMI and HIV. Breast cancer survivorship research, i.e. the health of women with breast cancer post- treatment, has largely been neglected in sub-Saharan Africa. ABC-DO-Plus will examine, for the first time, longitudinal changes in health-related quality of life up to 5 years after a woman’s breast cancer diagnosis. ABC-DO-Plus will inform interventions needed to mitigate the excessive number of deaths of women with the disease, and improve the quality-of-life of survivors. Utilizing a within-African framework of five countries with different cancer care politics, but also representing individual socioeconomic and cultural diversity, will enable comparisons across settings and hereby identification of modifiable factors influencing BC survival. Furthermore, its findings on the proportions of more aggressive tumor molecular subtypes, and how these may affect survival, as well as on the impact on survival of comorbidities such as HIV, will be of relevance to other black women in the US and elsewhere. The success of the proposed ABC-DO-Plus, and its manifold goals, will be ensured through continuity of the experience of the previous 4+ years’ ABC-DO fieldwork, its established research infrastructure, and the efficient mHealth follow-up approach of this unique cohort.

项目摘要 乳腺癌是被诊断出的最常见类型的癌症类型，是 撒哈拉以南非洲妇女的癌症死亡。关于乳腺癌生存的少数研究 地区报告的短期生存率较低，但没有一个能够全面解决 生存率较低的原因，如何提高生存率，或评估五年和长期生存的原因 和生存。此外，更具侵略性的分子亚型的影响，女性常见 尚未研究非洲兴趣的关于撒哈拉以南非洲乳腺癌的生存。 结果中的非洲乳腺癌分散性（ABC-DO）研究是一项五国 撒哈拉以南非洲乳腺癌队列于2014年启动。在招募3年期间 在乌干达，尼日利亚，赞比亚，纳米比亚和南非招募了2100名妇女。在 拟议的项目，ABC-Do-Plus，我们将建立在ABC-DO上 - 即已建立的 合作，研究人员，肿瘤收集，道德和法律许可；和小说和 成功的移动健康（MHealth）实施后续行动 - 积极跟进女性 在诊断后再诊断2年至5年 关键的预后因素，分子亚型，治疗可用性，可负担性和合规性， 在这种情况下，尤其是BMI和 艾滋病病毒。 乳腺癌生存研究，即乳腺癌妇女的健康 在撒哈拉以南非洲，治疗在很大程度上被忽略了。 ABC Do-Plus将检查 第一次，在女性乳房后，与健康相关的生活质量的纵向变化长达5年 癌症诊断。 ABC Do-Plus将告知减轻过量死亡人数所需的干预措施 利用患有该疾病的妇女的非洲室内，并改善生存质量。 具有不同癌症护理政治的五个国家的框架，但也代表个人 社会经济和文化多样性将在环境中进行比较，从而 可修改因素的鉴定会影响BC存活。 此外，它在更具侵略性肿瘤分子亚型的比例上的发现， 以及这些如何影响生存，以及对合并症生存的影响（例如 艾滋病毒将与美国和其他地方的其他黑人妇女有关。 将确保拟议的ABC Do-Plus及其多种目标的成功 通过过去4年以上ABC DO野外工作的经验的连续性，其已建立 研究基础设施以及这种独特队列的有效MHealth随访方法。