Diversity Supplement to the Transitions from Impaired Respiratory Health to Lung Disease

从呼吸系统健康受损到肺部疾病的转变的多样性补充

• 批准号: 10414648
• 负责人: RAVI KALHAN
• 金额: $ 6.47万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10414648
• 关键词: African American; Award; Chronic; Chronic Obstructive Airway Disease; Chronic lung disease; Clinical Research; Community Health; Coronary Arteriosclerosis; Crime; Data; Development; Disease; Educational workshop; Enrollment; Epidemiology; Exposure to; Funding; Future; Goals; Green space; Health; Impairment; Intercept; Internal Medicine; Intervention; K-Series Research Career Programs; Knowledge; Life; Lung; Lung diseases; Mentors; National Heart, Lung, and Blood Institute; Neighborhoods; Participant; Physicians; Postdoctoral Fellow; Primary Prevention; Pulmonary Emphysema; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonology; Research; Research Personnel; Research Project Grants; Research Technics; Respiratory Signs and Symptoms; Risk; Risk Factors; Scanning; Scientist; Social Environment; Supervision; Testing; Training; United States National Institutes of Health; Violence; Work; X-Ray Computed Tomography; aged; career; career development; clinical investigation; cohort; deprivation; design; disorder risk; follow-up; improved; indexing; lung development; lung injury; multidisciplinary; novel; parent grant; pulmonary function; respiratory; respiratory health; skills; tool; walkability; young adult; African American; Award; Chronic; Chronic Obstructive Airway Disease; Chronic lung disease; Clinical Research; Community Health; Coronary Arteriosclerosis; Crime; Data; Development; Disease; Educational workshop; Enrollment; Epidemiology; Exposure to; Funding; Future; Goals; Green space; Health; Impairment; Intercept; Internal Medicine; Intervention; K-Series Research Career Programs; Knowledge; Life; Lung; Lung diseases; Mentors; National Heart, Lung, and Blood Institute; Neighborhoods; Participant; Physicians; Postdoctoral Fellow; Primary Prevention; Pulmonary Emphysema; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonology; Research; Research Personnel; Research Project Grants; Research Technics; Respiratory Signs and Symptoms; Risk; Risk Factors; Scanning; Scientist; Social Environment; Supervision; Testing; Training; United States National Institutes of Health; Violence; Work; X-Ray Computed Tomography; aged; career; career development; clinical investigation; cohort; deprivation; design; disorder risk; follow-up; improved; indexing; lung development; lung injury; multidisciplinary; novel; parent grant; pulmonary function; respiratory; respiratory health; skills; tool; walkability; young adult

PROJECT SUMMARY/ABSTRACT The goal of this diversity supplement is to facilitate Dr. Daniel Meza's development as an independent physician- scientist and a leader in respiratory epidemiology, with a focus on the primary prevention and interception of chronic obstructive pulmonary disease. This diversity supplement for a post-doctoral award in support of Dr. Meza will aid his career development as a physician-investigator focused on understanding the impact of social environments on future lung health and disease. This will allow the candidate to develop the necessary skills and leverage study findings for the submission of a National Institutes of Health (NIH) career development (K) award prior to completing the supplement. This work exploring novel risk factors for impaired respiratory health is aligned with the parent grant and its central hypotheses. The candidate and his mentors have designed a specific training plan that builds upon his background in internal medicine, pulmonary medicine, and clinical investigation and aims toward launching his career as an independent investigator. This plan includes developing additional skills during the award period through (1) coursework designed to expand his knowledge and training in clinical research techniques, (2) interaction with a multidisciplinary team of sponsors and collaborators, including those in pulmonary and epidemiology, and (3) a supervised research project with national funding. The overall scientific objective of this project is to identify neighborhood factors that impair respiratory health through two primary specific aims: (1) determine whether neighborhood factors (green space, walkability index, and exposure to crime/violence) in young adulthood are associated with respiratory symptoms and decline in lung function over 20-25 years of follow-up and (2) To determine whether neighborhood factors in young adulthood are associated with greater risk of emphysema and lung injury later in life. This will be the first study to obtain and analyze neighborhood factors in the Coronary Artery Disease Risk in Young Adults (CARDIA) cohort. The CARDIA cohort has multiple strengths, including the original enrollment of young adults aged 18-30, 51% of participants identifying as Black or African-American, and having 35 years of follow-up data. It is essential to identify risk factors for decline of lung health and development of chronic lung abnormalities. We plan to expand on our prior work, which examined neighborhood deprivation, to now investigate specific neighborhood factors and their association with developing respiratory symptoms, decline in FEV1, and development of lung disease. Our proposal advances the goal of NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases by looking at neighborhood factors as a novel trigger that in the future can be analyzed to intercept future chronic lung disease.

项目摘要/摘要 这种多样性补充的目的是促进丹尼尔·梅扎（Daniel Meza）博士作为独立医师的发展 - 科学家和呼吸流行病学领域的领导者，重点是主要的预防和拦截 慢性阻塞性肺疾病。这种多样性补充是为支持博士提供支持的博士后奖。 梅扎（Meza）将有助于他作为医生评估者的职业发展，致力于了解社会的影响 关于未来肺部健康和疾病的环境。这将使候选人能够发展必要的技能 并利用研究结果来提交国立卫生研究院（NIH）职业发展（K） 在完成补充剂之前奖励。这项工作探讨了呼吸健康受损的新风险因素 与父母赠款及其中心假设保持一致。候选人和他的导师设计了 特定的培训计划基于他的内科，肺医学和临床的背景 调查并旨在启动他作为独立调查员的职业生涯。该计划包括制定 通过（1）课程旨在扩大他的知识和培训的课程，在奖励期间的其他技能 在临床研究技术中，（2）与赞助商和合作者的多学科团队的互动， 包括肺部和流行病学的人，以及（3）由国家资助的监督研究项目。 该项目的总体科学目标是确定损害呼吸健康的邻里因素 通过两个主要目的：（1）确定邻里因素（绿色空间，步行性指数， 成年年轻的犯罪/暴力暴露与呼吸道症状有关和下降 肺部功能超过20 - 25年的随访，（2）确定年轻的邻里因素是否是否 成年与以后生活中的肺气肿和肺损伤更大有关。这将是第一个研究 获得和分析年轻人冠状动脉疾病风险中的邻里因素（Cardia） 队列。 Cardia队列具有多种优势，包括18-30岁的年轻人的原始入学人数 51％的参与者识别为黑人或非裔美国人，并拥有35年的随访数据。这是必不可少的 确定肺部健康下降和慢性肺部异常发展的危险因素。我们计划 扩大我们先前检查社区剥夺的工作，现在调查特定的社区 因素及其与发展呼吸道症状的关联，FEV1的下降以及肺的发展 疾病。我们的建议促进了NHLBI研讨会的目标，以预防慢性肺 通过将邻里因素视为一种新颖的触发因素，将来可以分析疾病以拦截 未来的慢性肺病。