Understanding Transitions from Vaping to Smoking Across Adolescence

了解青春期从吸电子烟到吸烟的转变

基本信息

批准号：
10229446
负责人：
Jessica Louise Barrington-Trimis
金额：
$ 28万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10229446
关键词：
Address Adolescence Adolescent Age Antismoking Area Buffers Case-Control Studies Child Health Cigarette Cohort Studies Communities Data Data Analyses Data Pooling Dependence Development Drug usage Electronic cigarette Environment Epidemic Epidemiologist Familiarity Family Female Friends Future Gender Goals Grant Happiness Health Home Inhalation Intervention Interview Longitudinal cohort Longitudinal cohort study Manuscripts Matched Case-Control Study Measures Mentors Mentorship Modeling Nicotine Pathway interactions Pattern Pharmacology Physical environment Policies Population Predisposition Prevention Prevention strategy Psychometrics Psychopathology Public Health Qualitative Research Reading Recording of previous events Regulation Reporting Research Research Methodology Research Personnel Risk Risk Factors Role Sampling Scientist Sensory Smoke Smoker Smoking Social Characteristics Social Environment Social Perception Socioeconomic Factors Structure Surveys Taste Perception Teenagers Testing Tobacco Tobacco use Training Work Writing Youth addiction aged base burden of illness cigarette smoking cohort desensitization design development policy electronic cigarette use electronic cigarette user experience experimental study follow-up low socioeconomic status male meetings multidisciplinary never smoking novel pleasure population health prevent psychologic recruit response skills small social group smoking addiction social socioeconomic diversity socioeconomics theories therapy design tobacco products validation studies vaper vaping

项目摘要

PROJECT SUMMARY / ABSTRACT Despite the proliferation of adolescent e-cigarette use (i.e., vaping) and evidence of associations of vaping with cigarette initiation, research on whether vaping increases the risk of progression to regular, dependent smoking patterns and on factors that underlie these risk pathways are scant. Consequently, there are limited data to guide interventions to protect the growing population of adolescent vapers from transitioning to smoking. We hypothesize that a pro-tobacco social environment (e.g., lower socioeconomic environment in which smoking may be more accepted, proximity to tobacco retailers, having friends who smoke) may amplify the risk of transition from vaping to regular smoking and dependence, particularly among youth with a positive sensory-pharmacological response to their initial vaping experience who may therefore be more inclined to experiment with other tobacco products. This project will leverage data from two ongoing longitudinal cohorts to study vaping as a predictor of risk of smoking progression and dependence in adolescents aged 14-20 (Pooled N~3700; Aim 1a) and the role of the social environment and early vaping experience as moderators of this risk pathway (Aim 1b); we will also examine whether these associations differ by gender and age (Aim 1c). In a parallel project, we will conduct qualitative interviews with youth in these cohorts to uncover novel factors that influence this transition (N=60; Aim 2). Results from Aims 1 and 2 will be used to generate a new psychological survey to assess a novel construct of `susceptibility to transition from vaping to smoking.' We will conduct an initial validation study in a subset of youth vapers from both cohorts (N=200; Aim 3). Findings will be informative in (1) elucidating the possible harms that vaping may pose to population health by increasing youth smoking, which is important to guide development of policies and regulation of youth vaping; and (2) guiding the development of prevention strategies to address the social environment and alter the vaping experience to mitigate the risk of smoking among the rapidly increasing population of vaping adolescents. I enter this project with strong quantitative skills as an epidemiologist and growing experience in tobacco research. This K01 is critical for me to develop expertise in areas that will support my long-term goals to become an independent multi-disciplinary investigator of the intersecting environmental and intrapersonal determinants of adolescent tobacco and other drug use. The training proposed will help me to develop expertise in a) adolescent developmental psychopathology of addiction, b) qualitative research methodologies, and c) survey design and psychometric testing of survey items, with mentorship to additionally refine my skills in application of my research to inform policy and prevention efforts. I have worked closely with my mentors (selected based on their expertise in each training area) to develop an ambitious but feasible training plan that incorporates expert mentoring, directed readings, coursework and seminars, scientific meetings, and continued development of manuscript and grant writing skills.

项目概要/摘要尽管青少年电子烟使用（即电子烟）激增，并且有证据表明电子烟与开始吸烟，研究电子烟是否会增加发展为常规、依赖的风险吸烟模式和这些风险途径背后的因素很少。因此，有有限指导干预措施的数据，以保护不断增长的青少年电子烟使用者免于向电子烟使用者过渡吸烟。我们假设有利于烟草的社会环境（例如，较低的社会经济环境）哪种吸烟可能更容易被接受、靠近烟草零售商、有吸烟的朋友）可能会放大从电子烟过渡到经常吸烟和依赖的风险，特别是在具有积极态度的青少年中对他们最初的电子烟体验的感觉药理学反应，因此他们可能更倾向于尝试其他烟草制品。该项目将利用两个正在进行的纵向队列的数据研究电子烟作为 14-20 岁青少年吸烟进展和依赖风险的预测因素（汇总 N~3700；目标 1a）以及社会环境和早期电子烟体验作为调节因素的作用该风险路径（目标 1b）；我们还将检查这些关联是否因性别和年龄而异（目标 1c）。在一个并行项目中，我们将对这些群体中的年轻人进行定性访谈，以发现新的因素影响这一转变的因素（N=60；目标 2）。目标 1 和 2 的结果将用于生成新的心理调查评估“从电子烟过渡到吸烟的易感性”的新结构。我们将对两个队列中的青少年电子烟使用者子集进行初步验证研究（N=200；目标 3）。调查结果将在以下方面提供信息：（1）通过增加电子烟对人口健康可能造成的危害来阐明电子烟可能造成的危害青少年吸烟，这对于指导青少年电子烟政策和监管的制定具有重要意义；和（2）指导制定预防策略，以解决社会环境问题并改变电子烟使用习惯在迅速增加的电子烟青少年群体中降低吸烟风险的经验。作为一名流行病学家，我以强大的定量技能和不断增长的烟草经验进入这个项目研究。 K01 对于我在支持我的长期目标的领域发展专业知识至关重要成为交叉环境和个人内部的独立多学科调查员青少年吸烟和其他药物使用的决定因素。建议的培训将帮助我发展 a) 青少年成瘾发展精神病理学的专业知识，b) 定性研究方法， c) 调查设计和调查项目的心理测试，并在指导下进一步提高我的技能应用我的研究为政策和预防工作提供信息。我和我的导师密切合作（根据他们在每个培训领域的专业知识进行选择）制定雄心勃勃但可行的培训计划包括专家指导、定向阅读、课程作业和研讨会、科学会议以及持续的手稿和拨款写作技巧的发展。