Preclinical Therapeutics Shared Resource

临床前治疗共享资源

• 批准号: 10406943
• 负责人: ROSEMARY J AKHURST
• 金额: $ 44.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-05 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10406943
• 关键词: Biological Markers; Cancer Center Support Grant; Cancer Model; Cells; Characteristics; Clinical Oncology; Consultations; Data; Drug Interactions; Drug Kinetics; Ensure; Equipment; Experimental Designs; Generations; Genetic; Goals; Imaging technology; Infrastructure; Interventional radiology; Investigation; Malignant Neoplasms; Modality; Molecular; Pharmaceutical Preparations; Pharmacodynamics; Pharmacology; Postdoctoral Fellow; Quality Control; Reproducibility; Research; Research Personnel; Resource Sharing; Rodent; Services; Therapeutic; Training; Translating; Translational Research; Tumor Biology; antitumor drug; base; clinical predictors; cost effectiveness; efficacy trial; experience; germ free condition; graduate student; in vivo; in vivo Model; in vivo imaging; member; mouse model; novel therapeutics; patient derived xenograft model; pre-clinical; precision medicine; preclinical toxicity; response; tumor growth

Preclinical Therapeutics Shared Resource: Summary/Abstract The goal of the Preclinical Therapeutics Shared Resource (PCT) is to provide streamlined in vivo preclinical therapeutic services and training to HDFCCC members. The PCT uses state-of-the-art rodent cancer models, therapeutic delivery modalities, and live imaging technologies to facilitate generation of high-quality data that may be translated into clinical oncology research. The PCT facilitates translational research by providing a full suite of in vivo rodent services to HDFCCC investigators. The PCT ensures a stable infrastructure for small rodent cancer studies within a specific pathogen-free (SPF) barrier, facilitating rigor and reproducibility, cost- effectiveness, and quality control.

临床前治疗共享资源：摘要/摘要 临床前治疗共享资源 (PCT) 的目标是提供简化的体内临床前治疗 为 HDFCCC 会员提供治疗服务和培训。 PCT 使用最先进的啮齿动物癌症模型， 治疗交付方式和实时成像技术，以促进高质量数据的生成 可以转化为临床肿瘤学研究。 PCT 通过提供完整的信息来促进转化研究 为 HDFCCC 研究人员提供的一套体内啮齿动物服务。 PCT 确保小型企业拥有稳定的基础设施 在特定的无病原体（SPF）屏障内进行啮齿动物癌症研究，促进严谨性和可重复性，成本 有效性和质量控制。