The interaction between vocal fold hydration and vibratory biomechanics

声带水合与振动生物力学之间的相互作用

• 批准号: 10407530
• 负责人: Jack J Jiang
• 金额: $ 35.03万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407530
• 关键词: Acoustics; Affect; Anatomy; Animal Model; Benign; Biomechanics; Blood capillaries; Blood flow; Canis familiaris; Capillary Permeability; Clinical; Clinical Management; Computer Models; Cyst; Dehydration; Drug or chemical Tissue Distribution; Dysphonia; Edema; Elements; Ensure; Equilibrium; Etiology; Evaluation; Fluid Balance; Frequencies; Goals; Homeostasis; Hydration status; Inflammation; Inflammatory Response; Intention; Intercellular Fluid; Knowledge; Laryngoscopes; Larynx; Laser-Doppler Flowmetry; Lead; Lesion; Link; Liquid substance; Maintenance; Measurement; Measures; Mechanics; Methods; Modeling; Movement; Nodule; Optical Coherence Tomography; Oryctolagus cuniculus; Pathologic; Pathology; Patients; Persons; Phonation; Physiological; Polyps; Property; Relaxation; Reporting; Research; Role; Severities; Solid; Speed; Stress; Study Subject; Surface; Technology; Tissues; Trauma; Validation; Voice; Voice Disorders; Voice Quality; Water; accurate diagnostics; base; capillary bed; clinical application; clinically significant; dielectric property; external ear auricle; in vivo; in vivo Model; interest; mechanical properties; new technology; novel; pressure; response; social; socioeconomics; tissue stress; tool; translation to humans; trend; ultrasound; vibration; vocal cord

Project Summary/Abstract Voice disorders affect millions of people worldwide. Patients have reported many negative social econmic impacts of dysphonia. Proper fluid homeostasis is critical to normal vocal fold function. Maintenance of normal fluid levels in vocal fold tissue ensures normal biomechanical and vibratory parameters. Potential disturbances to this homeostasis include overuse, misuse, systemic or surface dehydration, trauma, and inflammation. The results of these disturbances can lead to changes in stress distribution, mechanical damage, and inflammation. Further damage to the tissue might result in the formation of edema or a benign lesion. The overall goal of this proposal is to evaluate the contributions of vocal fold fluid homeostasis, tissue properties, and vibratory biomechanics to tissue damage and ultimately edema. The results will explain changes in vibration mechanics over extended periods of phonation. Methods of quantifying fluid content in excised and in vivo models developed in this proposal will provide necessary information on fluid content and further our knowledge and understanding of the role of fluid in vocal fold vibration. Knowledge gained from this research is essential for a more complete understanding of clinical management of voice disorders. The approach to this research will involve three specific aims. The first aim will focus on methods of quantifying fluid content and tissue properties. We will employ four technologies novel to laryngology: (1) tissue dielectric properties (TDP), a measure of tissue water content; (2) Optical Coherence Tomography (OCT) as a method to quantify fluid volume in tissues; (3) laser Doppler flowmetry, a measure of blood flow through a tissue; and (4) acoustoelastography, a measure of the acoustic properties of the tissue that is linearly related to strain and nonlinearly related to tissue stress. The results of these methods will be useful for establishing standards in interstitial fluid levels and tissue properties. The second aim will focus on evaluating the effects of vibration on fluid content and dynamics in the vocal folds. First, finite element modeling will be used to study the effects of vibration on fluid content and dynamics while varying elongation, subglottal pressure, capillary permeability and stiffness. Physiological validation of the model trends will be carried out on excised animal models. Finally, an animal model of inflammation due to prolonged vibration will be used to observe how edema might occur in vocal overuse. The third aim will focus on the effects of fluid content on vocal fold vibration. We will determine hydration levels at which the vocal folds are pathologically changed. In other words, when there is a significant change to phonation parameters such as phonation threshold pressure. Excised models will be used in this aim to study the biomechanical effects of dehydration and overhydration. In addition, acoustoelastography will be employed to study the change in stress distribution of the tissue with changes in fluid content.

项目摘要/摘要 语音障碍会影响全球数百万的人。患者报告了许多负面社会 吞咽困难的经济影响。适当的流体稳态对于正常的人声折叠功能至关重要。维护 声带组织中正常的流体水平可确保正常的生物力学和振动参数。潜在的 对这种体内平衡的扰动包括过度使用，滥用，系统性或表面脱水，创伤和 炎。这些干扰的结果可能导致压力分布，机械损伤， 和炎症。对组织的进一步损害可能导致水肿形成或良性病变。 该提案的总体目标是评估人声折叠液稳态的贡献， 组织特性和振动生物力学对组织损伤和最终湿气。结果将 解释在延长的发声期间的振动力学变化。量化流体的方法 该建议中开发的切除和体内模型中的内容将提供有关流体的必要信息 内容并进一步了解我们对流体在声带振动中的作用的了解和理解。知识 从这项研究中获得的对语音临床管理的更全面了解至关重要 疾病。 这项研究的方法将涉及三个具体目标。第一个目标将重点放在 量化流体含量和组织特性。我们将采用四种新型技术到喉科：（1）组织 介电性能（TDP），是组织水含量的量度； （2）光学相干断层扫描（OCT）作为 定量组织中的流体体积的方法； （3）激光多普勒流量指标，通过 组织; （4）大声型的仪表术，与组织的声学特性的量度相关 应变和非线性与组织应激相关。这些方法的结果将有助于建立 间质流体水平和组织特性的标准标准。第二个目标将重点用于评估 流体含量和人声折叠的动力学的振动。首先，有限元建模将用于研究 振动对流体含量和动力学的影响，同时延伸，毛细管毛细管，毛细管 渗透性和刚度。模型趋势的生理验证将在切除的动物上进行 型号。最后，将使用长时间振动引起的炎症动物模型来观察如何 水肿可能在声带过度使用中发生。第三个目标将集中于流体含量对人声折叠的影响 振动。我们将确定声带在病理上改变的水合水平。在其他 单词，当发音参数（例如发音阈值压力）发生重大变化时。 切除的模型将用于研究脱水和过度水的生物力学作用。在 此外，将采用大弹药来研究组织应力分布的变化 流体含量的变化。

项目成果

Study of spatiotemporal liquid dynamics in a vibrating vocal fold by using a self-oscillating poroelastic model.

使用自振荡多孔弹性模型研究振动声带中的时空液体动力学。

• DOI: 10.1121/10.0002163
• 发表时间: 2020
• 期刊: The Journal of the Acoustical Society of America
• 作者: Scholp,Austin;Jeddeloh,Caroline;Tao,Chao;Liu,Xiaojun;Dailey,SethH;Jiang,JackJ
• 通讯作者: Jiang,JackJ