2014 Cardiac Regulatory Mechanisms Gordon Research Conference & Gordon Research S

2014年心脏调节机制戈登研究会议

• 批准号: 8784793
• 负责人: MARK E ANDERSON
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-05 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8784793
• 关键词: Area; Arrhythmia; Cardiac; Cardiac Myocytes; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Treatment; Data; Development; Diagnosis; Discipline; Disease; Ensure; Fostering; Functional disorder; Funding; Future; Genetic; Genetic Models; Genetically Modified Animals; Geography; Health; Heart; Human; Human Genetics; Image; Information Technology; Ion Channel; Ions; Knockout Mice; Learning; Mechanics; Medicine; Mentors; MicroRNAs; Mitochondria; Modeling; Molecular; Muscle Cells; Nature; Oral; Oxidation-Reduction; Participant; Phenotype; Physiology; Postdoctoral Fellow; Prevention; Process; Property; Publications; Published Comment; Recruitment Activity; Regulation; Research; Research Personnel; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Source; Staging; Techniques; Time; Transgenic Mice; Translating; Translations; Work; abstracting; base; career; college; drug development; experience; field study; graduate student; induced pluripotent stem cell; innovation; interest; mouse model; new technology; next generation; novel; planetary Atmosphere; posters; public health relevance; symposium; tool

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 7-13, 2014. For over 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. The common interest is the topic of regulation of the normal and diseased heart with a focus on specific regulatory mechanisms that can be translated to novel therapies. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including application of iPS cells to model human myocardial disease, mitochondrial Ca2+ regulation, redox regulation, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and emerging techniques to advance our field of study. Discussion leaders promote lively discussions and critical questioning. A key objective of this conference is to foster an inclusive, intensive, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of resolved issues. The inclusiveness of this conference in 2012 was enhanced by the GRS, a mechanism for highlighting work by graduate students and post-doctoral trainees. The GRS was well-received and will be held immediately prior to the GRC at Colby-Sawyer College. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies, including iPS cells that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.

描述（由申请人提供）： 本申请为将于 2014 年 6 月 7 日至 13 日在科尔比索耶学院（新罕布什尔州科尔比索耶）举行的戈登研究会议 (GRC) 和戈登心脏调节机制研究研讨会 (GRS) 寻求部分资助。对于超过 25多年来，这次会议一直以汇集新的研究人员和知名领导人而自豪，他们展示了他们最新的未发表的发现，并进行了有意义的科学和社会互动。 GRC 的非正式性质是独一无二的，它可以促进跨学科和地理的讨论，并促进新的个人和科学联系的发展。参与者是从最有前途和最有生产力的科学家中选出的，他们处于职业生涯的各个阶段，来自不同的学科。共同兴趣是正常和患病心脏的调节主题，重点是可以转化为新疗法的特定调节机制。我们拥有与正常心脏电和机械特性的调节、心肌细胞信号传导以及这些过程中导致心脏功能障碍的异常相关的基础科学的良好组合。转基因动物的使用增加和明确的心血管表型的发展使心血管系统变得易于处理，从而引起细胞信号传导领域广泛且不断扩大的兴趣。今年的会议特别关注信号通路，包括几个备受研究兴趣的新领域，包括应用 iPS 细胞模拟人类心肌疾病、线粒体 Ca2+ 调节、氧化还原调节、亚细胞区室及其实时成像。其他会议重点关注心律失常、肌细胞中的 Ca2+ 信号传导以及推动我们研究领域发展的新兴技术。讨论领导者促进热烈的讨论和批判性的提问。本次会议的一个主要目标是促进包容性、 紧张、活跃、互动的氛围凸显争议，通过对已解决的问题提供更深入的理解来启发参与者。 2012年这次会议的包容性通过GRS这一突出研究生和博士后实习生工作的机制得到了加强。 GRS 受到热烈欢迎，并将在 GRC 之前在 Colby-Sawyer 学院举行。这是心血管科学领域一个激动人心的时刻，因为转基因和基因敲除小鼠模型、遗传信息和新技术（包括 iPS 细胞）的使用使我们能够探索正常心脏功能的细胞和分子基础。我们开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们希望拟议的演讲既令人兴奋又及时，并通过从海报投稿和最近的出版物中招募演讲者，将最新突破的科学和年轻的研究人员纳入口头会议。这是一次定期参加的会议，新与会者和年轻科学家都认为这是一次宝贵的学习和职业经历。