2012 Cardiac Regulatory Mechanisms Gordon Research Conference and Gordon Research

2012年心脏调节机制戈登研究会议和戈登研究

• 批准号: 8316613
• 负责人: MARK E ANDERSON
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316613
• 关键词: Area; Arrhythmia; Biological Models; Cardiac; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Charge; Clinical; Clinical Treatment; Consensus; Data; Development; Diagnosis; Discipline; Disease; Ensure; Fostering; Functional disorder; Funding; Genetic; Genetically Modified Animals; Geography; Health; Heart; Heart Diseases; Image; Information Technology; Ion Channel; Ions; Knockout Mice; Lead; Learning; Mechanics; Mentors; Mitochondria; Molecular; Muscle Cells; Nature; Oral; Oxidation-Reduction; Participant; Phenotype; Phosphorylation; Phosphotransferases; Physiology; Prevention; Process; Property; Publications; Recruitment Activity; Regulation; Research; Research Personnel; Resolution; Role; Science; Scientist; Signal Pathway; Signal Transduction; Social Interaction; Source; Staging; Time; Transgenic Mice; Translating; Translations; base; career; college; experience; innovation; interest; mouse model; new technology; next generation; novel; novel therapeutics; planetary Atmosphere; posters; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) and the Gordon Research Seminar (GRS) on Cardiac Regulatory Mechanisms to be held at Colby Sawyer College (Colby-Sawyer, NH) on June 9-15, 2012. For more than 25 years this conference has prided itself on bringing together new investigators and established leaders to present their latest unpublished findings and engage in meaningful scientific and social interactions. The special informal nature of the GRC is unique in fostering discussions that span disciplines and geography and enables new personal and scientific connections to develop. Accordingly, an extraordinarily high number of scientists return to this conference year after year. Participants are chosen from amongst the most promising and productive scientists, at all stages in their careers and from diverse disciplines. Their bond is a common interest in the topic of regulation of the normal and diseased heart with a focus on Ca2+ regulatory mechanisms. We have a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The increased use of genetically modified animals and the development of defined cardiovascular phenotypes has made the cardiovascular system tractable and thus of broad and expanding interest to the cell signaling field. This year's conference has a particular focus on signaling pathways and includes several new areas of intense research interest including mitochondrial Ca2+ regulation, redox regulation, new model systems, subcellular compartments and their real time imaging. Other sessions focus on arrhythmias, Ca2+ signaling in myocytes, and novel signaling pathways. Discussion leaders are charged with and are historically successful at promoting lively discussions and critical questioning. Indeed a key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that highlights controversies and enlightens participants by providing a deeper understanding of unresolved issues. This is an exciting time in cardiovascular science because of the use of transgenic and knockout mouse models, genetic information and new technologies that allow us to explore the cellular and molecular basis of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We expect that the proposed presentations will be both exciting and timely, and to include late breaking science and young investigators in the oral session by recruiting speakers from poster contributions and recent publications. This is a conference that those who have regularly attended look forward to, and that new attendees and young scientists recognize as an invaluable learning and career experience.

描述（由申请人提供）：本申请为将于 6 月 9 日在科尔比索耶学院（新罕布什尔州科尔比索耶）举行的戈登研究会议 (GRC) 和戈登心脏调节机制研究研讨会 (GRS) 寻求部分资助。 2012 年 10 月 15 日。25 年来，本次会议一直以汇集新研究者和知名领导者而自豪，展示他们最新未发表的发现并参与有意义的科学和社会互动。 GRC 特殊的非正式性质在促进跨学科和地理的讨论方面是独一无二的，并能够发展新的个人和科学联系。因此，年复一年，有非常多的科学家回到这个会议。参与者是从最有前途和最有生产力的科学家中选出的，他们处于职业生涯的各个阶段，来自不同的学科。他们的羁绊是 对正常和患病心脏的调节主题有共同兴趣，重点是 Ca2+ 调节机制。我们拥有与正常心脏电和机械特性的调节、心肌细胞信号传导以及这些过程中导致心脏功能障碍的异常相关的基础科学的良好组合。转基因动物的使用增加和明确的心血管表型的发展使心血管系统变得易于处理，从而引起细胞信号传导领域广泛且不断扩大的兴趣。今年的会议特别关注信号通路，包括几个备受研究兴趣的新领域，包括线粒体 Ca2+ 调节、氧化还原调节、新模型系统、亚细胞区室及其实时成像。其他会议重点关注心律失常、肌细胞中的 Ca2+ 信号传导以及新的信号传导途径。讨论领导者负责促进活跃的讨论和批判性提问，并且在这方面历来都取得了成功。事实上，本次会议的一个关键目标是营造一种包容、激烈、活跃和互动的氛围，通过对未解决的问题提供更深入的理解，突出争议并启发与会者。这是心血管科学领域的一个激动人心的时刻，因为转基因和基因敲除小鼠模型、遗传信息和新技术的使用使我们能够探索正常心脏功能的细胞和分子基础。我们开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们希望拟议的演讲既令人兴奋又及时，并通过从海报投稿和最近的出版物中招募演讲者，将最新突破的科学和年轻的研究人员纳入口头会议。这是一次定期参加的会议，新与会者和年轻科学家都认为这是一次宝贵的学习和职业经历。