Core A Scientific and Administrative Integration: Thymic and peripheral Aspects of T cell Aging and Rejuvenation

核心 A 科学和行政整合：T 细胞衰老和复兴的胸腺和外周方面

• 批准号: 10226916
• 负责人: JANKO Z. NIKOLICH
• 金额: $ 12.2万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226916
• 关键词: Address; Adopted; Aging; Annual Reports; Area; Arizona; Cell Aging; Charge; Collaborations; Communication; Complex; Computer software; Custom; Data; Data Analyses; Data Collection; Data Set; Discipline; Ensure; Evaluation; Evaluation Reports; Fertilization; Fostering; Gerontology; Goals; Human Resources; Immunology; Individual; Information Resources Management; Infrastructure; Knowledge; Laboratories; Logistics; Metadata; Monitor; Nerve; Ontology; Organism; Peripheral; Persons; Productivity; Progress Reports; Protocols documentation; Quality Control; Reagent; Rejuvenation; Research; Research Personnel; Science; Scientific Evaluation; Scientist; Secure; Series; Standardization; Supervision; System; T-Lymphocyte; Testing; Text; Thymus Gland; Time; Training Programs; Travel; Videoconferencing; Visit; Work; adjudicate; animal tissue; base; cell type; cohesion; data management; data mining; data sharing; large scale data; meetings; member; multidisciplinary; operation; programs; success; symposium; synergism; terabyte; wiki

The success of multidisciplinary, multi-investigator scientific programs critically depends not only on the scientific quality of the individual research programs and their thematic synergy, but equally on the ability of the group to work together and to stay on course to accomplish larger goals of the common endeavor. Even greater scientific advancements are possible if teams can enhance the quality of science by cross-fertilization of ideas and the potential to draw new conclusions from cross-analysis of data contributed by studying different components of the same system (organism). Coordination of the above issues is particularly critical when the area of research lies at an interface of two complex disciplines, as is clearly the case with immunology and gerontology research. All of the above necessitates a deliberate and systematic approach to ensure Program success at all levels. To that effect, the Scientific Integration and Administration Core (Core A) will be the nerve center of the Program, coordinating every aspect of its scientific and administrative progress. Specific Aims are to: SA1. Ensure scientific communication and exchange via: (i) regular monthly group videoconference meetings; (ii) a common and interactive experimental planning and data sharing space – the Thymus Rejuvenation PPG Wiki and (iii) annual in-person PPG progress meetings. Thes Core will also organize and promote animal, tissue and reagent sharing via the above Wiki. SA2. Ensure fiscal and administrative oversight by monitoring spending with regard to specific aims and productivity of individual Projects and ensure timely annual reporting to the sponsor. SA3. Organize and implement scientific oversight. via (i) an internal PPG Scientific Steering Committee (PSSC), consisting of Project Leaders; and (ii) an external advisory board (EAB) composed of 3-4 scientists with strong expertise in the area of the Program. SA 4. Provide coordinated data and knowledge sharing and management platforms to enable the distributed team members to securely share and manage data sets ; and to allow teams to document experimental progress and results, and share laboratory protocols and datasets. This SA will also host and perform version control of MiCASA morphometric software and organize training of Program personnel by P1 staff. The platforms will be aligned to the needs of Core B and will be optimized via controlled ontologies, standardized meta-data collection, and common ID conventions to facilitate data mining, cross- fertilization and cross-discovery, by answering a series of specific inter-project questions formulated by the Program Scientific Steering Committee. This Core will therefore foster scientific integration at the highest level, while providing administrative cohesion.

多学科、多研究者的科学项目的成功不仅取决于 各个研究项目的科学质量及其主题协同作用，但同样取决于研究人员的能力 团队共同努力，坚持到底，以实现共同努力的更大目标。 如果团队能够通过交叉授精来提高科学质量，则可能取得更大的科学进步 的想法以及从研究不同贡献的数据交叉分析中得出新结论的潜力 当同一系统（有机体）的组成部分之间的协调时，上述问题就显得尤为关键。 研究领域位于两个复杂学科的交汇处，免疫学和 所有上述研究都需要采取深思熟虑和系统的方法来确保计划的实施。 在各个层面上取得成功。 为此，科学整合和管理核心（核心 A）将成为该系统的神经中枢。 该计划协调其科学和行政进展的各个方面，具体目标是： SA1. 通过以下方式确保科学沟通和交流： (i) 每月定期召开小组视频会议 会议；(ii) 一个共同的、交互式的实验规划和数据共享空间——Thymus Rejuvenation PPG Wiki 和 (iii) 年度现场 PPG 进展会议也将组织。 并通过上述维基促进动物、组织和试剂共享。 SA2. 通过监控特定目标的支出来确保财政和行政监督 和各个项目的生产力，并确保及时向赞助商提交年度报告。 SA3. 通过 (i) 内部 PPG 科学指导委员会组织和实施科学监督。 (PSSC)，由项目负责人组成；以及 (ii) 由 3-4 名成员组成的外部顾问委员会 (EAB) 在该计划领域具有丰富专业知识的科学家。 SA 4. 提供协调的数据和知识共享和管理平台，使 分布式团队成员可以安全地共享和管理数据集，并允许团队记录； 该 SA 还将托管和共享实验进展和结果，并共享实验室协议和数据集。 对MiCASA形态测量软件进行版本控制并组织项目人员培训 P1 人员的平台将根据核心 B 的需求进行调整，并通过受控进行优化。 本体、标准化元数据收集和通用 ID 约定，以促进数据挖掘、跨 通过回答一系列具体的项目间问题来进行施肥和交叉发现 计划科学指导委员会。 因此，该核心将促进最高水平的科学整合，同时提供行政凝聚力。