Scientific Integration and Administration

科学整合与管理

• 批准号: 10553989
• 负责人: JANKO Z. NIKOLICH
• 金额: $ 15.63万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553989
• 关键词: Address; Animals; Annual Reports; Area; Cell Aging; Charge; Collaborations; Collection; Communication; Complex; Data; Data Analyses; Discipline; Documentation; Ensure; Environment; Evaluation; Evaluation Reports; Fertilization; Fostering; Gerontology; Goals; Human Resources; Immunology; Individual; Infrastructure; Knowledge; Knowledge Management; Laboratories; Metadata; Monitor; Mus; Nerve; Ontology; Organism; Peripheral; Persons; Phase; Productivity; Progress Reports; Protocols documentation; Qualifying; Quality Control; Reagent; Rejuvenation; Reproducibility; Research; Research Personnel; Science; Scientific Advances and Accomplishments; Scientific Evaluation; Scientist; Secure; Standardization; Supervision; System; T-Lymphocyte; Technology; Text; Thymus Gland; Tissues; Travel; Videoconferencing; Visit; Work; Writing; adjudication; analytical tool; cohesion; cyber infrastructure; data harmonization; data mining; data sharing; experimental study; meetings; member; multidisciplinary; operation; programs; single-cell RNA sequencing; success; symposium; synergism; terabyte; videoconference; wiki

CORE A- Abstract The success of multidisciplinary, multi-investigator scientific programs critically depends not only on the scientific quality of the individual research programs and their thematic synergy, but equally on the ability of the group to work together and to stay on course to accomplish larger goals of the common endeavor. Even greater scientific advancements are possible if teams can enhance the quality of science by cross-fertilization of ideas and the potential to draw new conclusions from cross-analysis of data contributed by studying different components of the same system (organism). Coordination of the above issues is particularly critical when the area of research lies at an interface of two complex disciplines, as is clearly the case with research at the interface of immunology and gerontology. All of the above necessitates a deliberate and systematic approach to ensure Program success at all levels. To that effect, the Scientific Integration and Administration Core (Core A) will be the nerve center of the Program, coordinating every aspect of its scientific and administrative progress. Specific Aims are to: SA1. Ensure scientific communication and exchange via: (i) regular monthly group videoconference meetings; (ii) a common and interactive experimental planning and data sharing space – the Thymus Rejuvenation PPG GoogleDoc platform and (iii) annual in-person PPG progress meetings. This Core will also organize and promote animal, tissue and reagent sharing via the above three means. SA2. Ensure fiscal and administrative oversight by monitoring spending with regard to specific aims and productivity of individual Projects and ensure timely annual reporting to the sponsor. SA3. Organize and implement scientific oversight. via (i) an internal PPG Scientific Steering Committee (PSSC), consisting of Project Leaders; and (ii) an external advisory board (EAB) composed of three scientists with strong expertise in the areas of the Program. SA 4. Provide coordinated data and knowledge sharing and management platforms (DKMP) to enable the distributed team members to securely share and harmonize data; to facilitate documentation of experimental progress and results; and to share laboratory protocols and analytic tools. This SA will oversee coordination of experimental data flowing to Core B that will be optimized via controlled ontologies, standardized meta-data collection, and common ID conventions to facilitate data mining, and cross-discovery between P1-P3. A Project Management Platform (PMP) utilizing GoogleDocs and Wiki technologies will facilitate inter-Project and Core interactions and delivery of Program goals under the guidance of the PSSC (see SA3). Of particular importance are the integration of single cell RNA-Seq data across projects, that will be integral for answering Program-level hypotheses. This Core will therefore foster scientific integration at the highest level, while providing administrative cohesion.

核心A-抽象 多学科的多学科科学计划的成功不仅取决于 单个研究计划的科学质量及其主题协同作用，但同样地取决于 小组共同努力并保持课程，以实现共同努力的更大目标。甚至 如果团队可以通过交叉利用来提高科学质量，则可以进行更大的科学进步 思想以及通过研究不同的数据的交叉分析得出新结论的潜力 同一系统（生物体）的组成部分。当上述问题的协调尤其至关重要时 研究领域位于两个复杂学科的界面，就像在 免疫学和老年病的界面。以上所有必要 确保计划在各个层面上取得成功。 为此，科学整合和管理核心（核心A）将成为神经中心 计划，协调其科学和行政进步的各个方面。具体目的是： SA1。通过以下方式确保科学沟通和交流：（i）定期每月小组视频会议 会议； （ii）一种常见且互动的实验计划和数据共享空间 - 百里香 恢复活力的PPG GoogleDoc平台和（III）年度面对面的PPG进度会议。这个核心将 还通过上述三种方法组织和促进动物，组织和试剂共享。 SA2。通过监视针对特定目标的支出来确保财政和行政监督 和个人项目的生产力，并确保及时向赞助商报告。 SA3。组织和实施科学监督。通过（i）内部PPG科学指导委员会 （PSSC），由项目负责人组成； （ii）由三个组成的外部顾问委员会（EAB） 在该计划领域具有强大专业知识的科学家。 SA 4。提供协调的数据和知识共享和管理平台（DKMP） 使分布式团队成员能够安全共享和协调数据；促进文档 实验进步和结果；并共享实验室协议和分析工具。这个SA会 监督将通过受控优化核心B的实验数据的协调 本体论，标准化的元数据收集以及促进数据挖掘的常见ID惯例，以及 P1-P3之间的跨发现。使用GoogleDocs和Wiki的项目管理平台（PMP） 技术将促进项目间和核心的互动以及计划目标的实现 PSSC的指导（请参阅SA3）。特别重要的是单细胞RNA-seq数据的集成 在整个项目中，这将是回答计划级假设的组成部分。 因此，该核心将在最高级别促进科学整合，同时提供行政凝聚力。