Scientific Integration and Administration

科学整合与管理

• 批准号: 10553989
• 负责人: JANKO Z. NIKOLICH
• 金额: $ 15.63万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553989
• 关键词: Address; Animals; Annual Reports; Area; Cell Aging; Charge; Collaborations; Collection; Communication; Complex; Data; Data Analyses; Discipline; Documentation; Ensure; Environment; Evaluation; Evaluation Reports; Fertilization; Fostering; Gerontology; Goals; Human Resources; Immunology; Individual; Infrastructure; Knowledge; Knowledge Management; Laboratories; Metadata; Monitor; Mus; Nerve; Ontology; Organism; Peripheral; Persons; Phase; Productivity; Progress Reports; Protocols documentation; Qualifying; Quality Control; Reagent; Rejuvenation; Reproducibility; Research; Research Personnel; Science; Scientific Advances and Accomplishments; Scientific Evaluation; Scientist; Secure; Standardization; Supervision; System; T-Lymphocyte; Technology; Text; Thymus Gland; Tissues; Travel; Videoconferencing; Visit; Work; Writing; adjudication; analytical tool; cohesion; cyber infrastructure; data harmonization; data mining; data sharing; experimental study; meetings; member; multidisciplinary; operation; programs; single-cell RNA sequencing; success; symposium; synergism; terabyte; videoconference; wiki

CORE A- Abstract The success of multidisciplinary, multi-investigator scientific programs critically depends not only on the scientific quality of the individual research programs and their thematic synergy, but equally on the ability of the group to work together and to stay on course to accomplish larger goals of the common endeavor. Even greater scientific advancements are possible if teams can enhance the quality of science by cross-fertilization of ideas and the potential to draw new conclusions from cross-analysis of data contributed by studying different components of the same system (organism). Coordination of the above issues is particularly critical when the area of research lies at an interface of two complex disciplines, as is clearly the case with research at the interface of immunology and gerontology. All of the above necessitates a deliberate and systematic approach to ensure Program success at all levels. To that effect, the Scientific Integration and Administration Core (Core A) will be the nerve center of the Program, coordinating every aspect of its scientific and administrative progress. Specific Aims are to: SA1. Ensure scientific communication and exchange via: (i) regular monthly group videoconference meetings; (ii) a common and interactive experimental planning and data sharing space – the Thymus Rejuvenation PPG GoogleDoc platform and (iii) annual in-person PPG progress meetings. This Core will also organize and promote animal, tissue and reagent sharing via the above three means. SA2. Ensure fiscal and administrative oversight by monitoring spending with regard to specific aims and productivity of individual Projects and ensure timely annual reporting to the sponsor. SA3. Organize and implement scientific oversight. via (i) an internal PPG Scientific Steering Committee (PSSC), consisting of Project Leaders; and (ii) an external advisory board (EAB) composed of three scientists with strong expertise in the areas of the Program. SA 4. Provide coordinated data and knowledge sharing and management platforms (DKMP) to enable the distributed team members to securely share and harmonize data; to facilitate documentation of experimental progress and results; and to share laboratory protocols and analytic tools. This SA will oversee coordination of experimental data flowing to Core B that will be optimized via controlled ontologies, standardized meta-data collection, and common ID conventions to facilitate data mining, and cross-discovery between P1-P3. A Project Management Platform (PMP) utilizing GoogleDocs and Wiki technologies will facilitate inter-Project and Core interactions and delivery of Program goals under the guidance of the PSSC (see SA3). Of particular importance are the integration of single cell RNA-Seq data across projects, that will be integral for answering Program-level hypotheses. This Core will therefore foster scientific integration at the highest level, while providing administrative cohesion.

核心 A- 摘要 多学科、多研究者的科学项目的成功不仅取决于 各个研究项目的科学质量及其主题协同作用，但同样取决于研究人员的能力 团队共同努力，坚持到底，以实现共同努力的更大目标。 如果团队能够通过交叉授精来提高科学质量，则可能取得更大的科学进步 的想法以及从研究不同贡献的数据交叉分析中得出新结论的潜力 当同一系统（有机体）的组成部分之间的协调时，上述问题就显得尤为关键。 研究领域位于两个复杂学科的交汇处，显然，该研究的情况就是如此 所有上述内容都需要采取深思熟虑的系统方法。 确保计划在各个层面取得成功。 为此，科学整合和管理核心（核心 A）将成为该系统的神经中枢。 该计划协调其科学和行政进展的各个方面，具体目标是： SA1. 通过以下方式确保科学沟通和交流： (i) 每月定期召开小组视频会议 会议；(ii) 一个共同的、交互式的实验规划和数据共享空间——Thymus 振兴 PPG GoogleDoc 平台和 (iii) 年度现场 PPG 进展会议 该核心将。 并通过上述三种方式组织和推动动物、组织和试剂共享。 SA2. 通过监控特定目标的支出来确保财政和行政监督 和各个项目的生产力，并确保及时向赞助商提交年度报告。 SA3. 通过 (i) 内部 PPG 科学指导委员会组织和实施科学监督。 (PSSC)，由项目负责人组成；以及 (ii) 由三名成员组成的外部顾问委员会 (EAB) 在该计划领域具有丰富专业知识的科学家。 SA 4. 提供协调的数据和知识共享和管理平台（DKMP） 使分散的团队成员能够安全地共享和协调数据，以方便记录； 实验进展和结果；并分享实验室方案和分析工具。 监督流向核心 B 的实验数据的协调，这些数据将通过受控进行优化 本体、标准化元数据收集和通用 ID 约定以促进数据挖掘，以及 利用 GoogleDocs 和 Wiki 的 P1-P3 之间的交叉发现。 技术将促进项目间和核心互动以及项目目标的实现 PSSC 的指导（参见 SA3）特别重要的是单细胞 RNA-Seq 数据的整合。 跨项目，这对于回答计划层面的假设是不可或缺的。 因此，该核心将促进最高水平的科学整合，同时提供行政凝聚力。