Mechanisms that underlie poorer binaural outcomes in patients with asymmetrical hearing and bilateral cochlear implants

听力不对称且双侧人工耳蜗植入患者双耳结果较差的机制

• 批准号: 10226859
• 负责人: SEAN R ANDERSON
• 金额: $ 3.12万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226859
• 关键词: Acoustic Nerve; Adult; Affect; Age; Aging; Algorithms; Auditory system; Bilateral; Binaural; Brain Stem; Cell model; Cochlear Implants; Cochlear nucleus; Cognition; Collaborations; Communities; Computer Models; Computer software; Cues; Deterioration; Development; Disease; Ear; Electrophysiology (science); Exhibits; Frequencies; Future; Goals; Hearing; Hearing Aids; Implanted Electrodes; Knowledge; Laboratories; Lead; Light; Literature; Measures; Modeling; Nerve Fibers; Neurons; Noise; Outcome; Participant; Pathway interactions; Patient Self-Report; Patient-Focused Outcomes; Patients; Perception; Performance; Physiological; Physiology; Psychophysics; Reporting; Research; Scientist; Side; Sound Localization; Speech; Speech Perception; Stimulus; Testing; Training Programs; age effect; binaural hearing; career; computerized tools; design; experimental study; hearing impairment; improved; improved outcome; neural model; normal hearing; novel; preference; response; simulation; skills; sound; speech in noise; temporal measurement

PROJECT SUMMARY/ABSTRACT Binaural hearing allows listeners to better understand speech in noise and localize sounds. This proposal aims to develop a clearer understanding of the mechanisms that contribute to poorer binaural hearing abilities in patients with cochlear implants. The proposed experiments investigate the effects of poor hearing outcomes in one or both ears on speech perception and computational modeling of binaural processing in the brainstem. Abnormal speech perception with poor speech outcomes in one or both ears may contribute to poorer speech understanding in noise. Aim 1 will investigate differences in speech perception in cases of simulated or actual asymmetrical hearing, when speech understanding is poor in one or both ears. Factors that affect cochlear implant patients, namely the fidelity of temporal information conveyed by cochlear implant electrodes, will be simulated in younger and older listeners with normal hearing to account for aging effects. By testing participants with normal hearing and cochlear implants, results will have important implications for changes in perception with disease and perception with normal hearing. Poor encoding of binaural cues with asymmetrical hearing may result in reduced sensitivity to binaural cues and poorer sound localization performance. Aim 2 will develop a computational model of binaural encoding in the brainstem where one or both sides are deteriorated as in hearing impairment to predict the effects of hearing loss and cochlear implant stimulation on binaural processing. This approach will allow for an explanation of perceptual results in terms of the physiological mechanisms involved in the brainstem. Specific factors that affect patients with hearing loss and patients that use cochlear implants can be modeled and assessed separately to account for changes that occur along the binaural pathway. The training program will result in the development of the following specific scientific skills: (1) sound processing for cochlear implant simulations and speech perception experiments, (2) programming cochlear implants for direct connect experiments, (3) development and testing of computational models of binaural processing, and (4) ability to make electrophysiological recordings and understand their limitations. Each of these skills is critical to the applicant’s development as a scientist and future career in binaural hearing research. With these and other existing research skills, it will be possible to establish an independent and productive line of research concerning binaural hearing outcomes for adults with bilateral cochlear implants and normal hearing. Good binaural hearing improves the lives of patients. The results of the projects in this proposal will shed light on the perceptual and physiological problems that limit binaural hearing abilities in listeners with bilateral cochlear implants. Ultimately, these results will be important in understanding the limitations to binaural hearing for cochlear implants and improved cochlear implant processing strategies.

项目摘要/摘要 双耳听力使听众可以更好地理解噪音和本地化声音中的语音。这个建议 旨在对有助于较差的二元听力能力的机制有更清晰的了解 在人工耳蜗的患者中。提出的实验研究了听力不良的影响 在脑干中二进制处理的语音感知和计算建模的一只耳朵中。 语音感知异常，一只或两只耳朵的语音结果差可能有助于较差 噪音中的语音理解。 AIM 1将在模拟或 实际的不对称听力时，当一个或两只耳朵的语音理解很差时。影响人工耳蜗的因素 植入物患者，即通过人工耳蜗植入电极传达的临时信息的保真度，将是 在年轻和年长的听众中模拟，听力正常，以说明衰老的影响。通过测试参与者 有了正常的听力和人工耳蜗，结果将对感知变化产生重要影响 疾病和感知正常。 双耳线索与不对称听力的编码不良可能导致对双耳的敏感性降低 提示和较差的声音本地化性能。 AIM 2将开发双耳编码的计算模型 在脑干中，在听力障碍中确定一个或双方的脑干以预测 听力损失和人工耳蜗刺激二进制处理。这种方法将允许解释 根据脑干涉及的物理机制的感知结果。具体因素 可以对听力损失和使用人工耳蜗的患者进行建模和评估。 分别考虑沿二进制途径发生的变化。 培训计划将导致以下特定科学技能的发展：（1）声音 处理人工耳蜗模拟和语音感知实验的处理，（2）编程人工耳蜗 直接连接实验的植入物，（3）二进制计算模型的开发和测试 处理，以及（4）进行电生理记录并了解其局限性的能力。每个 技能对于申请人作为科学家的发展至关重要。和 这些和其他现有的研究技能，可以建立独立和生产力的线路 关于双边耳蜗的成年人的双耳听力结果的研究。 良好的双耳听力改善了患者的生活。该提案中项目的结果将脱离 关于限制双边听众双耳听力能力的感知和身体问题的启示 人工耳蜗。最终，这些结果对于理解二进制听证会的局限性将很重要 用于人工耳蜗，改善了人工耳蜗的关键处理策略。