Scientific Core

科学核心

• 批准号: 10227135
• 负责人: Kiran Bhaskar
• 金额: $ 22.97万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227135
• 关键词: Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease diagnostic; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; American Indians; Amyloid; Amyloid beta-Protein; Area; Award; Biological Assay; Biological Markers; Blood; Cancer Center; Caucasians; Clinical Services; Communities; Country; Data; Dementia; Deposition; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Education; Funding; Future; Goals; Grant; Image; Impaired cognition; Incidence; Inflammatory; Institution; Latino; Lead; Leukoaraiosis; Liquid substance; Magnetic Resonance Imaging; Measurement; Metalloproteases; Methods; Nerve Degeneration; New Mexico; Pathway interactions; Patients; Pattern; Phase; Play; Population; Populations at Risk; Predictive Analytics; Protocols documentation; Research; Research Personnel; Resources; Risk; Rural; Sampling; Scientist; Services; Socioeconomic Status; Standardization; Stratification; Technology; Testing; United States; United States National Institutes of Health; Universities; Vascular Dementia; Vascular Diseases; base; biomarker panel; blood-brain barrier permeabilization; cerebrovascular; clinical Diagnosis; cohort; contrast enhanced; data sharing; dementia risk; endophenotype; health care availability; health disparity; imaging capabilities; imaging modality; improved; innovation; neuroimaging; new technology; novel; novel marker; outreach; patient population; programs; racial and ethnic; racial diversity; ranpirnase; rural Americans; screening; socioeconomics; study population; tau Proteins; tool; urban Native American; white matter

PROJECT SUMMARY – Scientific Core In support of the New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC), the Scientific Core will centralize and expand existing expertise on Alzheimer’s disease biomarker research to the rural and urban American Indian (AI) communities in New Mexico. Specifically, the Scientific Core will establish ADNI- compatible, cerebrovascular focused neuroimaging, standardized assays for Aβ, tau and matrix metalloproteases (MMPs) in the blood and CSF samples and developing predictive analytics to distinguish different dementias in the rural and urban AI communities. Additional goals of the Scientific Core are to co- ordinate with the administrative core to have the biomarker data deposited to NACC and NCRAD, provide services to qualified investigators at University of New Mexico, across different institutions in the state and from other ADRCs/institutions across the nation. The Scientific Core also propose to expand the pool of dementia researchers by patterning with other centers/signature programs at the UNM and initiating new pilot programs on novel biomarkers/pathways related to Alzheimer’s disease and related disorders (AD/ADRD) research. The Scientific Core will support the NM eADRC to address one of the most important aspects of National Alzheimer’s Project Act on health disparities by successfully performing endophenotyping of the ‘at risk’ AI cohort. These goals will improve the limited screening clinical services available for dementia risk in AI population and also increase the representation of AI population in dementia research. These goals will be achieved by the Scientific Core under three specific aims. Aim 1: To provide expertise in magnetic resonance imaging (MRI) methods for understanding vascular contributions to dementia in Alzheimer’s disease and related disorders. Aim 2. To establish standardized assays for blood and CSF biomarker measurements for the dementia diagnosis and to develop and develop/test novel biomarkers that are currently used in the NIH- funded multi-center MarkVCID consortium study. Aim 3: Lead, coordinate, and develop dementia research across UNM and around the state via partnerships and pilot grant funding to carryout AD/ADRD research. Impact: Successful completion of all three specific aims of the Scientific Core will address one of the important gaps of test establish relationship across diverse racial, ethnic and socioeconomic backgrounds for dementia research, expand dementia research in NM and thus be ready for the P30 phase of ADRC in New Mexico in the near future.

项目摘要 - 科学核心 支持新墨西哥州探索性阿尔茨海默氏病研究中心（NM EADRC），科学 核心将集中并扩大有关阿尔茨海默氏病生物标志物研究的现有专业知识 新墨西哥州城市印第安人（AI）社区。具体而言，科学核心将建立ADNI- 兼容，脑血管聚焦的神经影像学，标准化Aβ，TAU和基质的标准化测定 血液和CSF样品中的金属蛋白酶（MMP），并开发预测分析以区分 在粗糙和城市的AI社区中的不同痴呆症。科学核心的其他目标是共同 用行政核心进行纵坐标，将生物标志物数据存入NACC和NCRAD，提供 为新墨西哥大学，该州的不同机构和来自的合格调查员提供服务 全国其他ADRC/机构。科学核心还建议扩大痴呆症库 研究人员通过与UNM的其他中心/签名计划进行构图，并启动新的试点计划 关于与阿尔茨海默氏病和相关疾病（AD/ADRD）研究有关的新型生物标志物/途径。这 科学核心将支持NM EADRC解决国家最重要的方面之一 阿尔茨海默（Alzheimer 队列。这些目标将改善AI中可用于痴呆症风险的有限筛查临床服务 人群，还增加了AI人群在痴呆症研究中的代表性。这些目标将是 目标1：提供磁共振方面的专业知识 成像（MRI）理解阿尔茨海默氏病和痴呆症血管贡献的方法 相关疾病。目标2。建立血液和CSF生物标志物测量的标准化评估 痴呆症诊断并开发和开发/测试NIH-目前使用的新型生物标志物 资助的多中心标记联盟研究。目标3：领导，协调和发展痴呆症研究 通过合作伙伴关系和飞行员赠款资金来进行广告/ADRD研究。 影响：成功完成科学核心的所有三个特定目标将解决重要的一个 痴呆的种族，种族和社会经济背景之间的测试建立关系差距 研究，扩大NM的痴呆研究，因此已准备好在新墨西哥州的ADRC的P30阶段 不久的将来。