Administrative Core

行政核心

基本信息

批准号：
10227134
负责人：
Gary Allen Rosenberg
金额：
$ 28.97万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10227134
关键词：
Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Indians Area Basic Science Biological Markers Blood Blood Vessels Budgets Caring Chairperson Clinical Cognitive Collaborations Communication Communities Community Health Consent Data Data Set Databases Dementia Diagnosis Elderly Ensure Event Faculty Funding Funding Mechanisms Geriatrics Goals Government Officials Grant Guidelines Head Health Occupations Human Image Image Analysis Imaging Device Incidence Inflammation Information Systems Infrastructure Link Magnetic Resonance Imaging Memory Mentorship Methods Mind-Body Method Minority Groups Molecular Neurology Neuropsychology Neurosciences New Mexico Newsletter Patient Recruitments Physicians Pilot Projects Population Prevalence Procedures Process Pueblo Race Research Research Personnel Research Project Grants Resources Role Rural Population Science Scientist Senior Scientist Services Site State Government Students Testing Textbooks Time Tissue Sample Training Translational Research Trust Underrepresented Minority United States National Institutes of Health Universities Vascular Diseases Work Zuni advocacy organizations clinical practice community organizations data submission early-career faculty experience health care service innovation insight interest medical schools meetings member neuroimaging next generation outreach programs quality assurance ranpirnase rural Americans screening service providers social media tau Proteins training opportunity transmission process undergraduate student urban Native American vaccine development vascular factor web site

项目摘要

Abstract Administrative Core: The Administrative Core (AC) of New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC) is critical for the management of the center by convening committees and interacting with NACC, NCRAD, and NIA. NM eADRC creates an infrastructure for AD science in New Mexico, raising the level of research participation in rural American Indian (AI) communities, and increasing the understanding of the role of vascular disease in AD and related dementias (AD/ADRD) through the use of biomarkers and advances in neuroimaging. The AC will ensure the successful completion of the aims in the Overall, Clinical and Scientific Cores. The AC will form committees to help achieve the goals of the NM eADRC. The AC will link senior scientists with junior faculty, trainees, clinical practice physicians and community health representatives (CHRs). The scientists in the NM eADRC are accomplished investigators with extensive experience managing large research projects, training junior investigators, and working as a team. The PI was head of Neurology at UNM and is director of the Center for Memory and Aging. As Chair, he managed two neuroscience CoBRE grants. The Co-Director of the NM eADRC is a nationally recognized researcher in AD and a leader in the development of a vaccine against tau protein. The AC Co-Leader is trained in geriatrics and neurology, co-edited the textbook on geriatric neurology and has engaged with local communities and state-wide organizations for many years in dementia related activities. Neuropsychology will be directed by Drs. Sadek and Prestopnik and neuroimaging by Drs. Caprihan and Kiehl. A demonstration/pilot project will use community health representatives and mobile MR imaging to bring AD research to the tribal areas with the Mobile On-Site Screening and Testing (MOSST), using the two mobile 1.5T MRI scanners at the MIND Research Network. The innovative work on developing vascular biomarkers will add a vascular component to the NIA-AA criterial for AD. BBB studies developed at UNM will provide insight into mechanisms of inflammation. A major advantage of the NM eADRC is the ability to include data from underrepresented minorities in the NACC, ADNI, and NCRAD databases. The NM eADRC will bring to the southwest a major center for research and innovative care in AD/ADRD that will utilize the outstanding scientific resources in the state, while building a greater understanding of the needs of rural and minority populations.

摘要行政核心：新墨西哥州探索性阿尔茨海默氏病研究中心（NM）的行政核心（AC） EADRC）对于通过召集委员会的管理并与之互动至关重要 NACC，NCRAD和NIA。 NM EADRC在新墨西哥州创建了广告科学的基础设施，在粗糙的美洲印第安人（AI）社区的研究水平，并增加了解血管疾病在AD和相关痴呆症（AD/ADRD）中的作用生物标志物和神经影像的进步。 AC将确保成功完成目标总体而言，临床和科学核心。 AC将组建委员会以帮助实现目标 NM EADRC。 AC将将高级科学家与初级教师，学员，临床实践医师和社区健康代表（CHRS）。 NM EADRC的科学家已完成拥有丰富经验的研究人员管理大型研究项目，培训初级研究人员，并作为团队合作。 PI是UNM的神经病学负责人，是记忆中心主任和老化。作为主席，他管理了两个神经科学的鞋垫赠款。 NM EADRC的联合导演是全国公认的AD研究人员，也是针对Tau的疫苗开发的领导者蛋白质。 AC联合领导者接受了老年医学和神经病学培训，并共同编辑了有关老年病的教科书神经病学并与当地社区和全州组织互动了很多年与痴呆有关的活动。神经心理学将由博士指导。 Sadek和Prestopnik以及 Drs神经影像。 Caprihan和Kiehl。示范/试点项目将使用社区健康代表和移动MR成像将广告研究带到部落区域筛选和测试（MOSST），使用两个移动性1.5T MRI扫描仪在思维研究中网络。开发血管生物标志物的创新工作将为 NIA-AA广告标准。在UNM开发的BBB研究将洞悉炎。 NM EADRC的主要优势是能够包含代表性不足的数据 NACC，ADNI和NCRAD数据库中的少数族裔。 NM EADRC将带到西南 AD/ADRD的主要研究与创新护理中心将利用杰出的科学该州的资源，同时对农村和少数群体的需求有更深入的了解人群。