New Mexico Alzheimer's Disease Research Center

新墨西哥州阿尔茨海默病研究中心

基本信息

批准号：
10450033
负责人：
Gary Allen Rosenberg
金额：
$ 101.9万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10450033
关键词：
Address Aging Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia American Indians Amyloid Area Autopsy Awareness BRAIN initiative Basic Science Biological Biological Markers Blood - brain barrier anatomy Blood Vessels Caring Clinic Clinical Clinical Services Cognition Cognitive Collaborations Communities Community Health Complement Data Data Set Databases Dementia Diffusion Magnetic Resonance Imaging Disease Education Educational Background Educational Status Elderly Faculty Feedback Functional disorder Funding Geriatrics Goals Grant Image Imaging Device Impaired cognition Incidence Inflammation Infrastructure Injury Lewy Body Dementia Liquid substance Low income MRI Scans Magnetic Resonance Imaging Measures Medical center Memory Minority Mission Movement Disorders Nerve Degeneration Neuropsychological Tests New Mexico Nursing Faculty Outcome Parkinson&apos s Dementia Participant Patient Recruitments Patients Population Population Heterogeneity Population Study Poverty Prevalence Prevention Process Pueblo Race Reduce health disparities Research Research Personnel Resources Rewards Risk Role Rural Rural Community Rural Population Sampling Scientist Services Site Socioeconomic Status Specialist Structure System Testing Training Travel Tribal Elders Tribes Universities Vascular Diseases Work Zuni base blood-brain barrier permeabilization cognitive function cognitive testing comorbidity contrast enhanced cost effective data repository dementia care education research gray matter health disparity high risk improved interest magnetic resonance imaging biomarker medical schools member mixed dementia multimodality neuropathology non-genetic novel outreach patient engagement patient population patient stratification precision medicine programs ranpirnase recruit remote location response rural Americans screening synergism tau Proteins tribal community vascular cognitive impairment and dementia vascular factor vascular inflammation vascular risk factor white matter

项目摘要

ABSTRACT (Overall Core) This proposal is to establish in New Mexico an exploratory Alzheimer's Disease Research Center (NM eADRC). The Center goals are: 1) to build infrastructure and hire faculty to enhance Alzheimer's disease (AD) research; 2) to meet the needs of rural communities with health disparities, and 3) to use multimodal biomarkers, including CSF and MRI, to incorporate vascular disease into the new NIA-AA Alzheimer's disease (AD) biological definition, improving patient stratefication. This P20 NM eADRC will build toward the P30 ADRC. We plan to hire new faculty with expertise in Alzheimer's disease (AD) and related dementias (RD). Infrastructure needs for care of the elderly will be met by the construction of new 7 million dollar building that will house three centers: Movement disorders, Geriatrics, and Center for Memory and Aging, creating synergy in care of the elderly. The NM eADRC will address the unmet needs in dementia care related to disparities, particularly in the large American Indian (AI) population. There are challenges to improving dementia care to AI that include cultural insensitivity, low income and educational levels, and long distances to travel for specialist care. We will overcome these barriers by using community health representatives to perform cognitive screening and a program for mobile on-site screening and testing (MOSST) that includes neuropsychological testing and mobile 1.5T MRI for imaging. This will fill a gap in the national AD databases for data on minorities. Vascular disease is a major co-morbidity with AD that accelerates the cognitive decline. It is estimated that up to 70% of nongenetic AD is mixed dementia (MX), making this an important group to identify prior to autopsy. We have developed biomarkers that can successfully stratify patients. This involves the use of CSF and MRI studies, and allows for the addition of the vascular feature (V) to the amyloid (A), tau (T), and neurodegeneration (N) components of the NIA-AA formula for diagnosis of AD. Biomarkers in the CSF have been identified by the MarkVCID consortium that indicate inflammation, which occurs when both AD and vascular disease are present. The NM eADRC will measure these unique biomarkers in the newly recruited participants, and provide these services to other ADRCs that are interested. The blood- brain barrier (BBB) has been implicated in the pathophysiology of AD. We plan to measure BBB permeability in gray and white matter in patients with AD and RD along with VCID and MX to better understand its role in dementia. The NM eADRC will be nidus for AD research to a large community of researchers around the state and will be major center within the Medical School Administrative structure. With the ability to bring in new faculty, build new buildings, and bring together the community of scientists interested in dementia in NM, it will make a huge impact that will provide the infrastructure for a successful P30 Center application.

摘要（整体核心）该建议是在新墨西哥州建立探索性阿尔茨海默氏病研究中心（NM） EADRC）。中心目标是：1）建立基础设施并聘请教师以增强阿尔茨海默氏病（AD）研究； 2）满足健康差异的农村社区的需求，3）包括CSF和MRI在内的多模式生物标志物将血管疾病纳入新的NIA-AA 阿尔茨海默氏病（AD）生物学定义，改善患者策略。这个P20 NM EADRC将朝着P30 ADRC建立。我们计划聘请具有阿尔茨海默氏病（AD）和相关痴呆症（RD）。新的基础设施需要照顾老年人的需求 700万美元的建筑将容纳三个中心：运动障碍，老年医学和中心记忆和衰老，创造协同作用，以照顾老年人。 NM EADRC将解决未满足的痴呆症护理的需求与差异有关，特别是在大型美洲印第安人（AI）人群中。改善痴呆症护理对AI的挑战，包括文化不敏感，低收入和教育水平和长途旅行以进行专业护理。我们将通过使用社区卫生代表进行认知筛查和用于移动现场的计划筛查和测试（MOSST），包括神经心理学测试和移动1.5T MRI 成像。这将填补国家广告数据库的空白，以获取有关少数群体的数据。血管疾病是与AD的主要合并症可以加速认知能力下降。据估计，多达70％ Nongenetic AD是混合痴呆症（MX），使其成为尸检之前识别的重要组。我们已经开发了可以成功分层患者的生物标志物。这涉及使用CSF和MRI 研究，并允许将血管特征（V）添加到淀粉样蛋白（a），tau（t）和 NIA-AA公式的神经变性（N）组件用于诊断AD。 CSF中的生物标志物已经通过指示炎症的Markvcid联盟确定存在AD和血管疾病。 NM EADRC将测量这些独特的生物标志物新招募的参与者，并向有兴趣的其他ADRC提供这些服务。鲜血脑屏障（BBB）与AD的病理生理有关。我们计划测量BBB AD和RD患者以及VCID和MX的灰色和白质的渗透性，以更好了解其在痴呆症中的作用。 NM EADRC将成为广告研究的NM 该州的研究人员将成为医学院行政结构的主要中心。有能力带来新的教师，建造新建筑并将科学家社区融合在一起对NM的痴呆症感兴趣，它将产生巨大的影响，将为A提供基础设施成功的P30中心申请。