Neuropathology Core

神经病理学核心

基本信息

批准号：
10228131
负责人：
WILLIAM W SEELEY
金额：
$ 1.81万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10228131
关键词：
Alzheimer&apos s Disease Anatomy Autopsy Biological Biological Markers Brain Brain Diseases British Columbia C9ORF72 Clinic Clinical Collaborations Communities Complex Consensus Data Data Collection Databases Diagnosis Diagnostic Differential Diagnosis Disease Drug or chemical Tissue Distribution Enrollment Equipment and supply inventories Event Financial Support Freezing Frontotemporal Lobar Degenerations Future Genes Goals Human Lead Leadership Link Location Medical Genetics Methods Molecular Mutation Neuroanatomy Neurodegenerative Disorders Neurologist Neurosciences Participant Pathogenicity Pathologic Pathology Patients Pilot Projects Process Proteins Research Research Personnel Resources Sampling Seminal Site Specimen Spinal Cord Syndrome Time Tissues Universities base clinical research site data management data standards design imaging biomarker immunoreactivity interest neuroimaging marker neuropathology novel protein TDP-43 repository success tau Proteins trend

项目摘要

ABSTRACT – ARTFL LEFFTDS Longitudinal FTLD: NEUROPATHOLOGY CORE Neurodegenerative disease pathology has become increasingly exciting and complex in recent years. This trend is particularly relevant to FTLD, with its many diverse and yet closely inter-related histopathological subtypes. The overarching goals of the ALLFTD Neuropathology Core will be to (1) enhance research within the ALLFTD consortium and (2) promote tissue-based FTLD research throughout the neurodegenerative disease research community. The core will be led by Drs. William Seeley, Dennis Dickson, and Ian Mackenzie, leading experts in FTLD anatomy and pathology. We aim to facilitate neuropathologic assessments and standardized data collection on ALLFTD participants, collect standardized data across sites, and bank fixed and frozen tissues for distribution to qualified investigators throughout the broader research community. We will perform a pilot study of inter-rater reliability of FTLD-TDP subtypes, and incorporate a novel FTLD-TDP module to enable standardized data collection. Finally, we will collaborate with ALLFTD researchers in the other Cores and Projects 1 and 2 to link clinical, genetic, imaging, and biomarker data to neuropathological data. Successful completion of these goals will have a major impact on the overall success of the ALLFTD consortium.

摘要 - ARTFL LEFFTDS纵向FTLD：神经病理学核心近年来，神经退行性疾病病理已经变得越来越令人兴奋和复杂。这趋势与FTLD特别相关，其许多潜水员却密切相关的组织病理学亚型。 AllFTD神经病理学核心的总体目标将是（1）增强内部研究 AllFTD联盟和（2）在整个神经退行性中促进基于组织的FTLD研究疾病研究界。核心将由博士领导。威廉·塞利（William Seeley），丹尼斯·迪克森（Dennis Dickson）和伊恩·麦肯齐（Ian Mackenzie） FTLD解剖学和病理学领域的主要专家。我们旨在促进神经病理学评估和对AllFTD参与者的标准化数据收集，跨站点收集标准化数据，以及固定的银行并冷冻组织以分配给整个更广泛的研究社区的合格研究人员。我们将对FTLD-TDP亚型的评价者间可靠性进行试点研究，并结合了一种新型的FTLD-TDP 模块启用标准化数据收集。最后，我们将与Allftd研究人员合作其他核心和项目1和2将临床，遗传，成像和生物标志物数据与神经病理学联系起来数据。成功完成这些目标将对AllFTD的整体成功产生重大影响财团。