Core D: Neuropathology Core

核心 D：神经病理学核心

基本信息

批准号：
10431782
负责人：
WILLIAM W SEELEY
金额：
$ 57.04万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10431782
关键词：
Age Age of Onset Anatomy Autopsy Basic Science Biological Biological Markers Biomaterials Research Brain Brain Stem Clinical Collaborations Communities Complex Consensus Custom DNA Data Databases Dementia Diagnosis Diagnostic Disease Doctor of Philosophy Educational process of instructing Elements Equipment and supply inventories Event Fibroblasts Fostering Freezing Genetic Goals Heterogeneity Human Image International Link Mentored Patient-Oriented Research Career Development Award Mentors Methods Nerve Degeneration Neurodegenerative Disorders Neurologist Neurosciences Paper Participant Pathogenicity Pathologic Pathology Patients Phenotype Publishing Research Research Personnel Research Support Resources Role Sampling Secure Services Ships Specimen Spinal Cord Stains Symptoms Time Tissues Training Translational Research Validation Work base biomarker discovery design imaging approach improved innovation meetings molecular imaging neuroimaging neuroinflammation neuropathology next generation novel strategies prion-like programs success symposium tau Proteins tissue processing

项目摘要

ABSTRACT The UCSF ADRC Neuropathology Core (Path Core) provides vital research support to the UCSF ADRC and to the neurodegenerative disease research community at UCSF and beyond. Neurodegenerative disease pathology has become increasingly exciting and complex in recent years, with major advances arising from work accomplished through this ADRC. In this application, the Path Core will continue to be led by Dr. William Seeley and co-led by Dr. Lea Grinberg. The Path Core aims to: (1) Obtain and bank human brain and spinal cord tissue for neuropathological characterization and research; (2) Analyze specimens and render neuropathological diagnoses; (3) Review tissue requests and distribute specimens; (4) Support innovative neuropathological approaches; (5) Train the next generation of neurologists and neuropathologists conducting research on neurodegenerative disease. These goals will be accomplished through extensive interactions with the other cores of the UCSF ADRC and will have a major impact on the overall success of the center.

抽象的 UCSF ADRC神经病理学核心（PATH CORE）为UCSF ADRC提供了重要的研究支持，并为 UCSF及其他地区的神经退行性疾病研究界。神经退行性疾病近年来，病理学变得越来越令人兴奋和复杂，主要进步是由通过此ADRC完成的工作。在此应用中，路径核心将继续由威廉博士领导。 Seeley，由Lea Grinberg博士共同主持。路径核心的目的是：（1）获得和库存人脑和脊柱用于神经病理学表征和研究的脐带组织；（2）分析标本和渲染神经病理学诊断；（3）审查组织请求并分发标本；（4）支持创新神经病理学方法；（5）训练下一代神经病学家和神经病理学家进行的神经退行性疾病的研究。这些目标将通过与 UCSF ADRC的其他核心将对中心的整体成功产生重大影响。