TR&D2: Nanoimmunomaterials for Immune Engineering

基本信息

批准号：
10223294
负责人：
Jordan Green
金额：
$ 31.05万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10223294
关键词：
Adoptive Cell Transfers Amines Antigens Biocompatible Materials Biodistribution Biological Biological Assay Biomedical Engineering Biomimetics Biophysics Biotechnology CD8-Positive T-Lymphocytes Cells Cellular immunotherapy Chemical Engineering Chemicals Collaborations Cytotoxic T-Lymphocytes Dendritic Cells Drug Kinetics Engineering Esters Formulation Gene Delivery Gene-Modified Goals Health Human Immune Immune system Immunization Immunosuppression Immunotherapeutic agent Immunotherapy In Situ In Vitro Libraries Mediating Membrane Fluidity Membrane Proteins Modification Nucleic Acids Nucleosome Core Particle Polymers Property Proteins Regulatory T-Lymphocyte Reporter Reporter Genes Reporting Research Personnel Safety Shapes Signal Transduction Signaling Molecule Specificity Surface Surface Properties System T-Cell Receptor T-Lymphocyte Techniques Technology Time Toxic effect Transfection Vision base biodegradable polymer biomaterial compatibility cell type cellular engineering comparative design engineered T cells extracellular flexibility fluidity genetic vaccine immunoengineering immunoregulation improved in vivo materials science melanoma mouse model nano nanoformulation nanomaterials nanoparticle next generation novel nucleic acid delivery particle physical property systemic toxicity tool tumor

项目摘要

TR&D2 Abstract / Narrative - Nanoimmunomaterials for Immune Engineering TR&D2 advances nanoimmunomaterials (NIMs) through the design and synthesis of new biomaterials and nanomaterials created for immunomodulation. Polymers and polymeric particle-based systems are constructed with independent control of the particle core physical properties and the chemical surface to enable desired biomimetic biological properties. NIMs are constructed for intracellular delivery of nucleic acids, extracellular presentation of biological molecules from surfaces, and for the combination of both mechanisms. These NIMs are utilized for both immunostimulatory and immunosuppressive applications. Additionally, NIMs will be shared with CP and SP projects, other TR&Ds, and for collaboration and use by varied researchers. NIMs will be evaluated to improve the efficacy of techniques for both Adoptive Cell Transfer (ACT) and particle-based acellular immunotherapeutics for wide ranging fields and applications to human health. TR&D2 supports and aligns with the JH-TIE vision in its use of engineering principles (Chemical Engineering, Materials Science & Engineering, and Biomedical Engineering) to design enabling immunoengineering technology and advanced immunotherapy.

TR&D2 摘要/叙述 - 用于免疫工程的纳米免疫材料 TR&D2 通过设计和合成新的生物材料和技术来推进纳米免疫材料 (NIM) 的发展用于免疫调节的纳米材料。构建聚合物和聚合物颗粒系统独立控制颗粒核心物理特性和化学表面，以实现所需的仿生生物学特性。 NIM 的构建用于核酸的细胞内传递、细胞外的传递从表面呈现生物分子，以及两种机制的结合。这些 NIM 用于免疫刺激和免疫抑制应用。此外，NIM 将被共享与 CP 和 SP 项目、其他 TR&D，以及供不同研究人员协作和使用。 NIM 将是经评估可提高过继细胞移植 (ACT) 和基于颗粒的技术的功效非细胞免疫疗法在人类健康领域的广泛应用。 TR&D2 支持和在工程原理（化学工程、材料科学和工程和生物医学工程）设计支持免疫工程技术和先进免疫疗法。